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Role of Citicoline in the Management of Traumatic Brain Injury
Head injury is among the most devastating types of injury, specifically called Traumatic Brain Injury (TBI). There is a need to diminish the morbidity related with TBI and to improve the outcome of patients suffering TBI. Among the improvements in the treatment of TBI, neuroprotection is one of the...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146347/ https://www.ncbi.nlm.nih.gov/pubmed/33926011 http://dx.doi.org/10.3390/ph14050410 |
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author | Secades, Julio J. |
author_facet | Secades, Julio J. |
author_sort | Secades, Julio J. |
collection | PubMed |
description | Head injury is among the most devastating types of injury, specifically called Traumatic Brain Injury (TBI). There is a need to diminish the morbidity related with TBI and to improve the outcome of patients suffering TBI. Among the improvements in the treatment of TBI, neuroprotection is one of the upcoming improvements. Citicoline has been used in the management of brain ischemia related disorders, such as TBI. Citicoline has biochemical, pharmacological, and pharmacokinetic characteristics that make it a potentially useful neuroprotective drug for the management of TBI. A short review of these characteristics is included in this paper. Moreover, a narrative review of almost all the published or communicated studies performed with this drug in the management of patients with head injury is included. Based on the results obtained in these clinical studies, it is possible to conclude that citicoline is able to accelerate the recovery of consciousness and to improve the outcome of this kind of patient, with an excellent safety profile. Thus, citicoline could have a potential role in the management of TBI. |
format | Online Article Text |
id | pubmed-8146347 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81463472021-05-26 Role of Citicoline in the Management of Traumatic Brain Injury Secades, Julio J. Pharmaceuticals (Basel) Review Head injury is among the most devastating types of injury, specifically called Traumatic Brain Injury (TBI). There is a need to diminish the morbidity related with TBI and to improve the outcome of patients suffering TBI. Among the improvements in the treatment of TBI, neuroprotection is one of the upcoming improvements. Citicoline has been used in the management of brain ischemia related disorders, such as TBI. Citicoline has biochemical, pharmacological, and pharmacokinetic characteristics that make it a potentially useful neuroprotective drug for the management of TBI. A short review of these characteristics is included in this paper. Moreover, a narrative review of almost all the published or communicated studies performed with this drug in the management of patients with head injury is included. Based on the results obtained in these clinical studies, it is possible to conclude that citicoline is able to accelerate the recovery of consciousness and to improve the outcome of this kind of patient, with an excellent safety profile. Thus, citicoline could have a potential role in the management of TBI. MDPI 2021-04-26 /pmc/articles/PMC8146347/ /pubmed/33926011 http://dx.doi.org/10.3390/ph14050410 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Secades, Julio J. Role of Citicoline in the Management of Traumatic Brain Injury |
title | Role of Citicoline in the Management of Traumatic Brain Injury |
title_full | Role of Citicoline in the Management of Traumatic Brain Injury |
title_fullStr | Role of Citicoline in the Management of Traumatic Brain Injury |
title_full_unstemmed | Role of Citicoline in the Management of Traumatic Brain Injury |
title_short | Role of Citicoline in the Management of Traumatic Brain Injury |
title_sort | role of citicoline in the management of traumatic brain injury |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146347/ https://www.ncbi.nlm.nih.gov/pubmed/33926011 http://dx.doi.org/10.3390/ph14050410 |
work_keys_str_mv | AT secadesjulioj roleofciticolineinthemanagementoftraumaticbraininjury |