Cargando…

Chitosan, alginate, hyaluronic acid, gums, and β-glucan as potent adjuvants and vaccine delivery systems for viral threats including SARS-CoV-2: A review

Pathogen transmission is a widespread threat to global human health. Vaccines are very important during the outbreak of a pandemic. Destructive fractures caused by a sudden outbreak of COVID-19 have spurred vaccine production at an unprecedented rate. The strategy of an effective vaccine delivery sy...

Descripción completa

Detalles Bibliográficos
Autores principales: Mallakpour, Shadpour, Azadi, Elham, Hussain, Chaudhery Mustansar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146404/
https://www.ncbi.nlm.nih.gov/pubmed/34048834
http://dx.doi.org/10.1016/j.ijbiomac.2021.05.155
_version_ 1783697388915916800
author Mallakpour, Shadpour
Azadi, Elham
Hussain, Chaudhery Mustansar
author_facet Mallakpour, Shadpour
Azadi, Elham
Hussain, Chaudhery Mustansar
author_sort Mallakpour, Shadpour
collection PubMed
description Pathogen transmission is a widespread threat to global human health. Vaccines are very important during the outbreak of a pandemic. Destructive fractures caused by a sudden outbreak of COVID-19 have spurred vaccine production at an unprecedented rate. The strategy of an effective vaccine delivery system is opening up novel probabilities to make more immunization. Indeed, vaccination is the most successful way to prevent deaths from infectious diseases. In order to optimal immune response production or improvement in the effectiveness of vaccines, delivery systems or adjuvants are required. Natural polymers such as chitosan, alginate, hyaluronic acid, gums, and β-glucan with antiviral activity have good potential as adjuvant or delivery systems for vaccine formulation development and design vaccine delivery devices. According to the antiviral performance and immunomodulation of these biopolymers, they will play significant characters in the anti-COVID-19 field. In this mini-review, the recent progress in vaccine development by using biopolymers is presented which, provides a reference for their research on anti-COVID-19 drugs and vaccines.
format Online
Article
Text
id pubmed-8146404
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier B.V.
record_format MEDLINE/PubMed
spelling pubmed-81464042021-05-25 Chitosan, alginate, hyaluronic acid, gums, and β-glucan as potent adjuvants and vaccine delivery systems for viral threats including SARS-CoV-2: A review Mallakpour, Shadpour Azadi, Elham Hussain, Chaudhery Mustansar Int J Biol Macromol Review Pathogen transmission is a widespread threat to global human health. Vaccines are very important during the outbreak of a pandemic. Destructive fractures caused by a sudden outbreak of COVID-19 have spurred vaccine production at an unprecedented rate. The strategy of an effective vaccine delivery system is opening up novel probabilities to make more immunization. Indeed, vaccination is the most successful way to prevent deaths from infectious diseases. In order to optimal immune response production or improvement in the effectiveness of vaccines, delivery systems or adjuvants are required. Natural polymers such as chitosan, alginate, hyaluronic acid, gums, and β-glucan with antiviral activity have good potential as adjuvant or delivery systems for vaccine formulation development and design vaccine delivery devices. According to the antiviral performance and immunomodulation of these biopolymers, they will play significant characters in the anti-COVID-19 field. In this mini-review, the recent progress in vaccine development by using biopolymers is presented which, provides a reference for their research on anti-COVID-19 drugs and vaccines. Elsevier B.V. 2021-07-01 2021-05-25 /pmc/articles/PMC8146404/ /pubmed/34048834 http://dx.doi.org/10.1016/j.ijbiomac.2021.05.155 Text en © 2021 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Mallakpour, Shadpour
Azadi, Elham
Hussain, Chaudhery Mustansar
Chitosan, alginate, hyaluronic acid, gums, and β-glucan as potent adjuvants and vaccine delivery systems for viral threats including SARS-CoV-2: A review
title Chitosan, alginate, hyaluronic acid, gums, and β-glucan as potent adjuvants and vaccine delivery systems for viral threats including SARS-CoV-2: A review
title_full Chitosan, alginate, hyaluronic acid, gums, and β-glucan as potent adjuvants and vaccine delivery systems for viral threats including SARS-CoV-2: A review
title_fullStr Chitosan, alginate, hyaluronic acid, gums, and β-glucan as potent adjuvants and vaccine delivery systems for viral threats including SARS-CoV-2: A review
title_full_unstemmed Chitosan, alginate, hyaluronic acid, gums, and β-glucan as potent adjuvants and vaccine delivery systems for viral threats including SARS-CoV-2: A review
title_short Chitosan, alginate, hyaluronic acid, gums, and β-glucan as potent adjuvants and vaccine delivery systems for viral threats including SARS-CoV-2: A review
title_sort chitosan, alginate, hyaluronic acid, gums, and β-glucan as potent adjuvants and vaccine delivery systems for viral threats including sars-cov-2: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146404/
https://www.ncbi.nlm.nih.gov/pubmed/34048834
http://dx.doi.org/10.1016/j.ijbiomac.2021.05.155
work_keys_str_mv AT mallakpourshadpour chitosanalginatehyaluronicacidgumsandbglucanaspotentadjuvantsandvaccinedeliverysystemsforviralthreatsincludingsarscov2areview
AT azadielham chitosanalginatehyaluronicacidgumsandbglucanaspotentadjuvantsandvaccinedeliverysystemsforviralthreatsincludingsarscov2areview
AT hussainchaudherymustansar chitosanalginatehyaluronicacidgumsandbglucanaspotentadjuvantsandvaccinedeliverysystemsforviralthreatsincludingsarscov2areview