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Immunoglobulin Response and Prognostic Factors in Repeated SARS-CoV-2 Positive Patients: A Systematic Review and Meta-Analysis

With repeated positivity being an undiscovered and major concern, we aimed to evaluate which prognostic factors may impact repeated SARS-CoV-2 positivity (RSP) and their association with immunoglobulin detectability among recovered patients. A systematic literature search was performed on 5 April 20...

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Autores principales: Dembrovszky, Fanni, Váncsa, Szilárd, Farkas, Nelli, Erőss, Bálint, Szakó, Lajos, Teutsch, Brigitta, Bunduc, Stefania, Nagy, Rita, Dohos, Dóra, Kiss, Szabolcs, Párniczky, Andrea, Vinkó, Zsófia, Péterfi, Zoltán, Hegyi, Péter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146492/
https://www.ncbi.nlm.nih.gov/pubmed/33946311
http://dx.doi.org/10.3390/v13050809
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author Dembrovszky, Fanni
Váncsa, Szilárd
Farkas, Nelli
Erőss, Bálint
Szakó, Lajos
Teutsch, Brigitta
Bunduc, Stefania
Nagy, Rita
Dohos, Dóra
Kiss, Szabolcs
Párniczky, Andrea
Vinkó, Zsófia
Péterfi, Zoltán
Hegyi, Péter
author_facet Dembrovszky, Fanni
Váncsa, Szilárd
Farkas, Nelli
Erőss, Bálint
Szakó, Lajos
Teutsch, Brigitta
Bunduc, Stefania
Nagy, Rita
Dohos, Dóra
Kiss, Szabolcs
Párniczky, Andrea
Vinkó, Zsófia
Péterfi, Zoltán
Hegyi, Péter
author_sort Dembrovszky, Fanni
collection PubMed
description With repeated positivity being an undiscovered and major concern, we aimed to evaluate which prognostic factors may impact repeated SARS-CoV-2 positivity (RSP) and their association with immunoglobulin detectability among recovered patients. A systematic literature search was performed on 5 April 2021. Cohort studies with risk factors for repeated RSP or information about the immunoglobulin response (immunoglobulin M (IgM) and/or immunoglobulin G (IgG)) were included in this analysis. The main examined risk factors were severity of the initial infection, body mass index (BMI), length of hospitalization (LOH), age, and gender, for which we pooled mean differences and odds ratios (ORs). Thirty-four cohort studies (N = 9269) were included in our analysis. We found that increased RSP rate might be associated with IgG positivity; IgG presence was higher in RSP patients (OR: 1.72, CI: 0.87–3.41, p = 0.117). Among the examined risk factors, only mild initial disease course showed a significant association with RSP (OR: 0.3, CI: 0.14–0.67, p = 0.003). Age, male gender, BMI, LOH, and severity of the first episode do not seem to be linked with repeated positivity. However, further prospective follow-up studies focusing on this topic are required.
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spelling pubmed-81464922021-05-26 Immunoglobulin Response and Prognostic Factors in Repeated SARS-CoV-2 Positive Patients: A Systematic Review and Meta-Analysis Dembrovszky, Fanni Váncsa, Szilárd Farkas, Nelli Erőss, Bálint Szakó, Lajos Teutsch, Brigitta Bunduc, Stefania Nagy, Rita Dohos, Dóra Kiss, Szabolcs Párniczky, Andrea Vinkó, Zsófia Péterfi, Zoltán Hegyi, Péter Viruses Review With repeated positivity being an undiscovered and major concern, we aimed to evaluate which prognostic factors may impact repeated SARS-CoV-2 positivity (RSP) and their association with immunoglobulin detectability among recovered patients. A systematic literature search was performed on 5 April 2021. Cohort studies with risk factors for repeated RSP or information about the immunoglobulin response (immunoglobulin M (IgM) and/or immunoglobulin G (IgG)) were included in this analysis. The main examined risk factors were severity of the initial infection, body mass index (BMI), length of hospitalization (LOH), age, and gender, for which we pooled mean differences and odds ratios (ORs). Thirty-four cohort studies (N = 9269) were included in our analysis. We found that increased RSP rate might be associated with IgG positivity; IgG presence was higher in RSP patients (OR: 1.72, CI: 0.87–3.41, p = 0.117). Among the examined risk factors, only mild initial disease course showed a significant association with RSP (OR: 0.3, CI: 0.14–0.67, p = 0.003). Age, male gender, BMI, LOH, and severity of the first episode do not seem to be linked with repeated positivity. However, further prospective follow-up studies focusing on this topic are required. MDPI 2021-04-30 /pmc/articles/PMC8146492/ /pubmed/33946311 http://dx.doi.org/10.3390/v13050809 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dembrovszky, Fanni
Váncsa, Szilárd
Farkas, Nelli
Erőss, Bálint
Szakó, Lajos
Teutsch, Brigitta
Bunduc, Stefania
Nagy, Rita
Dohos, Dóra
Kiss, Szabolcs
Párniczky, Andrea
Vinkó, Zsófia
Péterfi, Zoltán
Hegyi, Péter
Immunoglobulin Response and Prognostic Factors in Repeated SARS-CoV-2 Positive Patients: A Systematic Review and Meta-Analysis
title Immunoglobulin Response and Prognostic Factors in Repeated SARS-CoV-2 Positive Patients: A Systematic Review and Meta-Analysis
title_full Immunoglobulin Response and Prognostic Factors in Repeated SARS-CoV-2 Positive Patients: A Systematic Review and Meta-Analysis
title_fullStr Immunoglobulin Response and Prognostic Factors in Repeated SARS-CoV-2 Positive Patients: A Systematic Review and Meta-Analysis
title_full_unstemmed Immunoglobulin Response and Prognostic Factors in Repeated SARS-CoV-2 Positive Patients: A Systematic Review and Meta-Analysis
title_short Immunoglobulin Response and Prognostic Factors in Repeated SARS-CoV-2 Positive Patients: A Systematic Review and Meta-Analysis
title_sort immunoglobulin response and prognostic factors in repeated sars-cov-2 positive patients: a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146492/
https://www.ncbi.nlm.nih.gov/pubmed/33946311
http://dx.doi.org/10.3390/v13050809
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