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Intersection between Redox Homeostasis and Autophagy: Valuable Insights into Neurodegeneration
Autophagy, a main degradation pathway for maintaining cellular homeostasis, and redox homeostasis have recently been considered to play protective roles in neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Increased levels of reactive oxy...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146521/ https://www.ncbi.nlm.nih.gov/pubmed/33924878 http://dx.doi.org/10.3390/antiox10050694 |
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author | Park, Hyungsun Kim, Jongyoon Shin, Chihoon Lee, Seongju |
author_facet | Park, Hyungsun Kim, Jongyoon Shin, Chihoon Lee, Seongju |
author_sort | Park, Hyungsun |
collection | PubMed |
description | Autophagy, a main degradation pathway for maintaining cellular homeostasis, and redox homeostasis have recently been considered to play protective roles in neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Increased levels of reactive oxygen species (ROS) in neurons can induce mitochondrial damage and protein aggregation, thereby resulting in neurodegeneration. Oxidative stress is one of the major activation signals for the induction of autophagy. Upon activation, autophagy can remove ROS, damaged mitochondria, and aggregated proteins from the cells. Thus, autophagy can be an effective strategy to maintain redox homeostasis in the brain. However, the interaction between redox homeostasis and autophagy is not clearly elucidated. In this review, we discuss recent studies on the relationship between redox homeostasis and autophagy associated with neurodegenerative diseases and propose that autophagy induction through pharmacological intervention or genetic activation might be a promising strategy to treat these disorders. |
format | Online Article Text |
id | pubmed-8146521 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81465212021-05-26 Intersection between Redox Homeostasis and Autophagy: Valuable Insights into Neurodegeneration Park, Hyungsun Kim, Jongyoon Shin, Chihoon Lee, Seongju Antioxidants (Basel) Review Autophagy, a main degradation pathway for maintaining cellular homeostasis, and redox homeostasis have recently been considered to play protective roles in neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Increased levels of reactive oxygen species (ROS) in neurons can induce mitochondrial damage and protein aggregation, thereby resulting in neurodegeneration. Oxidative stress is one of the major activation signals for the induction of autophagy. Upon activation, autophagy can remove ROS, damaged mitochondria, and aggregated proteins from the cells. Thus, autophagy can be an effective strategy to maintain redox homeostasis in the brain. However, the interaction between redox homeostasis and autophagy is not clearly elucidated. In this review, we discuss recent studies on the relationship between redox homeostasis and autophagy associated with neurodegenerative diseases and propose that autophagy induction through pharmacological intervention or genetic activation might be a promising strategy to treat these disorders. MDPI 2021-04-28 /pmc/articles/PMC8146521/ /pubmed/33924878 http://dx.doi.org/10.3390/antiox10050694 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Park, Hyungsun Kim, Jongyoon Shin, Chihoon Lee, Seongju Intersection between Redox Homeostasis and Autophagy: Valuable Insights into Neurodegeneration |
title | Intersection between Redox Homeostasis and Autophagy: Valuable Insights into Neurodegeneration |
title_full | Intersection between Redox Homeostasis and Autophagy: Valuable Insights into Neurodegeneration |
title_fullStr | Intersection between Redox Homeostasis and Autophagy: Valuable Insights into Neurodegeneration |
title_full_unstemmed | Intersection between Redox Homeostasis and Autophagy: Valuable Insights into Neurodegeneration |
title_short | Intersection between Redox Homeostasis and Autophagy: Valuable Insights into Neurodegeneration |
title_sort | intersection between redox homeostasis and autophagy: valuable insights into neurodegeneration |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146521/ https://www.ncbi.nlm.nih.gov/pubmed/33924878 http://dx.doi.org/10.3390/antiox10050694 |
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