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Intersection between Redox Homeostasis and Autophagy: Valuable Insights into Neurodegeneration

Autophagy, a main degradation pathway for maintaining cellular homeostasis, and redox homeostasis have recently been considered to play protective roles in neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Increased levels of reactive oxy...

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Autores principales: Park, Hyungsun, Kim, Jongyoon, Shin, Chihoon, Lee, Seongju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146521/
https://www.ncbi.nlm.nih.gov/pubmed/33924878
http://dx.doi.org/10.3390/antiox10050694
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author Park, Hyungsun
Kim, Jongyoon
Shin, Chihoon
Lee, Seongju
author_facet Park, Hyungsun
Kim, Jongyoon
Shin, Chihoon
Lee, Seongju
author_sort Park, Hyungsun
collection PubMed
description Autophagy, a main degradation pathway for maintaining cellular homeostasis, and redox homeostasis have recently been considered to play protective roles in neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Increased levels of reactive oxygen species (ROS) in neurons can induce mitochondrial damage and protein aggregation, thereby resulting in neurodegeneration. Oxidative stress is one of the major activation signals for the induction of autophagy. Upon activation, autophagy can remove ROS, damaged mitochondria, and aggregated proteins from the cells. Thus, autophagy can be an effective strategy to maintain redox homeostasis in the brain. However, the interaction between redox homeostasis and autophagy is not clearly elucidated. In this review, we discuss recent studies on the relationship between redox homeostasis and autophagy associated with neurodegenerative diseases and propose that autophagy induction through pharmacological intervention or genetic activation might be a promising strategy to treat these disorders.
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spelling pubmed-81465212021-05-26 Intersection between Redox Homeostasis and Autophagy: Valuable Insights into Neurodegeneration Park, Hyungsun Kim, Jongyoon Shin, Chihoon Lee, Seongju Antioxidants (Basel) Review Autophagy, a main degradation pathway for maintaining cellular homeostasis, and redox homeostasis have recently been considered to play protective roles in neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Increased levels of reactive oxygen species (ROS) in neurons can induce mitochondrial damage and protein aggregation, thereby resulting in neurodegeneration. Oxidative stress is one of the major activation signals for the induction of autophagy. Upon activation, autophagy can remove ROS, damaged mitochondria, and aggregated proteins from the cells. Thus, autophagy can be an effective strategy to maintain redox homeostasis in the brain. However, the interaction between redox homeostasis and autophagy is not clearly elucidated. In this review, we discuss recent studies on the relationship between redox homeostasis and autophagy associated with neurodegenerative diseases and propose that autophagy induction through pharmacological intervention or genetic activation might be a promising strategy to treat these disorders. MDPI 2021-04-28 /pmc/articles/PMC8146521/ /pubmed/33924878 http://dx.doi.org/10.3390/antiox10050694 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Park, Hyungsun
Kim, Jongyoon
Shin, Chihoon
Lee, Seongju
Intersection between Redox Homeostasis and Autophagy: Valuable Insights into Neurodegeneration
title Intersection between Redox Homeostasis and Autophagy: Valuable Insights into Neurodegeneration
title_full Intersection between Redox Homeostasis and Autophagy: Valuable Insights into Neurodegeneration
title_fullStr Intersection between Redox Homeostasis and Autophagy: Valuable Insights into Neurodegeneration
title_full_unstemmed Intersection between Redox Homeostasis and Autophagy: Valuable Insights into Neurodegeneration
title_short Intersection between Redox Homeostasis and Autophagy: Valuable Insights into Neurodegeneration
title_sort intersection between redox homeostasis and autophagy: valuable insights into neurodegeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146521/
https://www.ncbi.nlm.nih.gov/pubmed/33924878
http://dx.doi.org/10.3390/antiox10050694
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