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The Anti-Ageing and Whitening Potential of a Cosmetic Serum Containing 3-O-ethyl-l-ascorbic Acid

Skin ageing has many manifestations such as wrinkles, dryness, hyperpigmentation, and uneven skin tone. Extrinsic and intrinsic factors, especially solar ultraviolet light (UVB), contribute to skin ageing; its main features are brown spots, alterations in melanin pigmentation, and a decrease in coll...

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Autores principales: Zerbinati, Nicola, Sommatis, Sabrina, Maccario, Cristina, Di Francesco, Serena, Capillo, Maria Chiara, Rauso, Raffaele, Herrera, Martha, Bencini, Pier Luca, Guida, Stefania, Mocchi, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146548/
https://www.ncbi.nlm.nih.gov/pubmed/33946734
http://dx.doi.org/10.3390/life11050406
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author Zerbinati, Nicola
Sommatis, Sabrina
Maccario, Cristina
Di Francesco, Serena
Capillo, Maria Chiara
Rauso, Raffaele
Herrera, Martha
Bencini, Pier Luca
Guida, Stefania
Mocchi, Roberto
author_facet Zerbinati, Nicola
Sommatis, Sabrina
Maccario, Cristina
Di Francesco, Serena
Capillo, Maria Chiara
Rauso, Raffaele
Herrera, Martha
Bencini, Pier Luca
Guida, Stefania
Mocchi, Roberto
author_sort Zerbinati, Nicola
collection PubMed
description Skin ageing has many manifestations such as wrinkles, dryness, hyperpigmentation, and uneven skin tone. Extrinsic and intrinsic factors, especially solar ultraviolet light (UVB), contribute to skin ageing; its main features are brown spots, alterations in melanin pigmentation, and a decrease in collagen and hyaluronic acid linked to oxidative stress. Several studies showed that topical products containing ingredients with antioxidant activity can reduce oxidative damage; to provide a maximum anti-ageing effect to the skin, topical products can combine various ingredients. C-SHOT SERUM contains a combination of two molecules with a proven anti-ageing activity: a high percentage (30%) of a more stable vitamin C derivative, 3-O-ethyl-l-ascorbic acid, and lactic acid (1%). The product showed a high biocompatibility, assessed through an MTT assay on keratinocytes and on Reconstructed Human Epidermis (RHE, SkinEthic); the anti-ageing activity was demonstrated on human dermal fibroblasts and keratinocytes by a statistically significant increase in collagen production and a reduction of a UVB-induced DNA damage marker (γ-H2AX histone), indicating DNA protection. Moreover, a depigmenting activity, shown by a highly significant decrease in melanin content on treated Reconstructed Human Pigmented Epidermis (RHPE), was assessed. According to the data of our study, the tested product contrasts the effect of skin ageing and irregular pigmentation due to the physiological decline of the skin.
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spelling pubmed-81465482021-05-26 The Anti-Ageing and Whitening Potential of a Cosmetic Serum Containing 3-O-ethyl-l-ascorbic Acid Zerbinati, Nicola Sommatis, Sabrina Maccario, Cristina Di Francesco, Serena Capillo, Maria Chiara Rauso, Raffaele Herrera, Martha Bencini, Pier Luca Guida, Stefania Mocchi, Roberto Life (Basel) Article Skin ageing has many manifestations such as wrinkles, dryness, hyperpigmentation, and uneven skin tone. Extrinsic and intrinsic factors, especially solar ultraviolet light (UVB), contribute to skin ageing; its main features are brown spots, alterations in melanin pigmentation, and a decrease in collagen and hyaluronic acid linked to oxidative stress. Several studies showed that topical products containing ingredients with antioxidant activity can reduce oxidative damage; to provide a maximum anti-ageing effect to the skin, topical products can combine various ingredients. C-SHOT SERUM contains a combination of two molecules with a proven anti-ageing activity: a high percentage (30%) of a more stable vitamin C derivative, 3-O-ethyl-l-ascorbic acid, and lactic acid (1%). The product showed a high biocompatibility, assessed through an MTT assay on keratinocytes and on Reconstructed Human Epidermis (RHE, SkinEthic); the anti-ageing activity was demonstrated on human dermal fibroblasts and keratinocytes by a statistically significant increase in collagen production and a reduction of a UVB-induced DNA damage marker (γ-H2AX histone), indicating DNA protection. Moreover, a depigmenting activity, shown by a highly significant decrease in melanin content on treated Reconstructed Human Pigmented Epidermis (RHPE), was assessed. According to the data of our study, the tested product contrasts the effect of skin ageing and irregular pigmentation due to the physiological decline of the skin. MDPI 2021-04-29 /pmc/articles/PMC8146548/ /pubmed/33946734 http://dx.doi.org/10.3390/life11050406 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zerbinati, Nicola
Sommatis, Sabrina
Maccario, Cristina
Di Francesco, Serena
Capillo, Maria Chiara
Rauso, Raffaele
Herrera, Martha
Bencini, Pier Luca
Guida, Stefania
Mocchi, Roberto
The Anti-Ageing and Whitening Potential of a Cosmetic Serum Containing 3-O-ethyl-l-ascorbic Acid
title The Anti-Ageing and Whitening Potential of a Cosmetic Serum Containing 3-O-ethyl-l-ascorbic Acid
title_full The Anti-Ageing and Whitening Potential of a Cosmetic Serum Containing 3-O-ethyl-l-ascorbic Acid
title_fullStr The Anti-Ageing and Whitening Potential of a Cosmetic Serum Containing 3-O-ethyl-l-ascorbic Acid
title_full_unstemmed The Anti-Ageing and Whitening Potential of a Cosmetic Serum Containing 3-O-ethyl-l-ascorbic Acid
title_short The Anti-Ageing and Whitening Potential of a Cosmetic Serum Containing 3-O-ethyl-l-ascorbic Acid
title_sort anti-ageing and whitening potential of a cosmetic serum containing 3-o-ethyl-l-ascorbic acid
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146548/
https://www.ncbi.nlm.nih.gov/pubmed/33946734
http://dx.doi.org/10.3390/life11050406
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