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Palliative Surgery or Metallic Stent Positioning for Advanced Gastric Cancer: Differences in QOL
Background and Objectives: Twenty percent of the patients affected with stage IV antropyloric stomach cancer are hospitalized with a gastric outlet obstruction syndrome (GOOS) requiring its resolution to improve the quality of life (QoL). We present our preliminary short- and mid-term results regard...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146574/ https://www.ncbi.nlm.nih.gov/pubmed/33925171 http://dx.doi.org/10.3390/medicina57050428 |
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author | Fiori, Enrico Crocetti, Daniele Sapienza, Paolo Cirocchi, Roberto Sterpetti, Antonio V. Miccini, Michelangelo Accordino, Marcello Costi, Silvano Lapolla, Pierfrancesco Mingoli, Andrea De Toma, Giorgio Lamazza, Antonietta |
author_facet | Fiori, Enrico Crocetti, Daniele Sapienza, Paolo Cirocchi, Roberto Sterpetti, Antonio V. Miccini, Michelangelo Accordino, Marcello Costi, Silvano Lapolla, Pierfrancesco Mingoli, Andrea De Toma, Giorgio Lamazza, Antonietta |
author_sort | Fiori, Enrico |
collection | PubMed |
description | Background and Objectives: Twenty percent of the patients affected with stage IV antropyloric stomach cancer are hospitalized with a gastric outlet obstruction syndrome (GOOS) requiring its resolution to improve the quality of life (QoL). We present our preliminary short- and mid-term results regarding the influence of endoscopic placement of self-expandable metal stent (SEMS) or open stomach-partitioning gastrojejunostomy in QoL. Materials and Methods: In this prospective randomized longitudinal cohort trial, we randomly assigned 27 patients affected with stage IV antropyloric stomach cancer into two groups: Group 1 (13 patients) who underwent SEMS positioning and Group 2 (14 patients) in whom open stomach-partitioning gastrojejunostomy was performed. The Karnofsky performance scale and QoL assessment using the EQ-5D-5L™ questionnaire was administered before treatment and thereafter at 1, 3, and 6 months. Results: At 1-month, index values showed a statistically significant deterioration of the QoL in patients of Group 2 when compared to those of Group 1 (p = 0.004; CI: 0.04 to 0.21). No differences among the groups were recorded at 3-month; whereas, at 6-month, the index values showed a statistically significant deterioration of the QoL in patients of Group 1 (p = 0.009; CI: −0.25 to −0.043). Conclusions: Early QoL of patients affected with stage IV antropyloric cancer and symptoms of GOOS is significantly better in patients treated with SEMS positioning but at 6-month the QoL significantly decrease in this group of patients. We explained the reasons of this fluctuation with the higher risk of re-hospital admission in the SEMS group. |
format | Online Article Text |
id | pubmed-8146574 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81465742021-05-26 Palliative Surgery or Metallic Stent Positioning for Advanced Gastric Cancer: Differences in QOL Fiori, Enrico Crocetti, Daniele Sapienza, Paolo Cirocchi, Roberto Sterpetti, Antonio V. Miccini, Michelangelo Accordino, Marcello Costi, Silvano Lapolla, Pierfrancesco Mingoli, Andrea De Toma, Giorgio Lamazza, Antonietta Medicina (Kaunas) Article Background and Objectives: Twenty percent of the patients affected with stage IV antropyloric stomach cancer are hospitalized with a gastric outlet obstruction syndrome (GOOS) requiring its resolution to improve the quality of life (QoL). We present our preliminary short- and mid-term results regarding the influence of endoscopic placement of self-expandable metal stent (SEMS) or open stomach-partitioning gastrojejunostomy in QoL. Materials and Methods: In this prospective randomized longitudinal cohort trial, we randomly assigned 27 patients affected with stage IV antropyloric stomach cancer into two groups: Group 1 (13 patients) who underwent SEMS positioning and Group 2 (14 patients) in whom open stomach-partitioning gastrojejunostomy was performed. The Karnofsky performance scale and QoL assessment using the EQ-5D-5L™ questionnaire was administered before treatment and thereafter at 1, 3, and 6 months. Results: At 1-month, index values showed a statistically significant deterioration of the QoL in patients of Group 2 when compared to those of Group 1 (p = 0.004; CI: 0.04 to 0.21). No differences among the groups were recorded at 3-month; whereas, at 6-month, the index values showed a statistically significant deterioration of the QoL in patients of Group 1 (p = 0.009; CI: −0.25 to −0.043). Conclusions: Early QoL of patients affected with stage IV antropyloric cancer and symptoms of GOOS is significantly better in patients treated with SEMS positioning but at 6-month the QoL significantly decrease in this group of patients. We explained the reasons of this fluctuation with the higher risk of re-hospital admission in the SEMS group. MDPI 2021-04-28 /pmc/articles/PMC8146574/ /pubmed/33925171 http://dx.doi.org/10.3390/medicina57050428 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Fiori, Enrico Crocetti, Daniele Sapienza, Paolo Cirocchi, Roberto Sterpetti, Antonio V. Miccini, Michelangelo Accordino, Marcello Costi, Silvano Lapolla, Pierfrancesco Mingoli, Andrea De Toma, Giorgio Lamazza, Antonietta Palliative Surgery or Metallic Stent Positioning for Advanced Gastric Cancer: Differences in QOL |
title | Palliative Surgery or Metallic Stent Positioning for Advanced Gastric Cancer: Differences in QOL |
title_full | Palliative Surgery or Metallic Stent Positioning for Advanced Gastric Cancer: Differences in QOL |
title_fullStr | Palliative Surgery or Metallic Stent Positioning for Advanced Gastric Cancer: Differences in QOL |
title_full_unstemmed | Palliative Surgery or Metallic Stent Positioning for Advanced Gastric Cancer: Differences in QOL |
title_short | Palliative Surgery or Metallic Stent Positioning for Advanced Gastric Cancer: Differences in QOL |
title_sort | palliative surgery or metallic stent positioning for advanced gastric cancer: differences in qol |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146574/ https://www.ncbi.nlm.nih.gov/pubmed/33925171 http://dx.doi.org/10.3390/medicina57050428 |
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