Clinical and epigenetic features of colorectal cancer patients with somatic POLE proofreading mutations

BACKGROUND: Mutations in the POLE gene result in an ultra-hypermutated phenotype in colorectal cancer (CRC); however, the molecular characterisation of epigenetic alterations remains unclear. We examined the genetic and epigenetic profiles of POLE-mutant CRC to elucidate the clinicopathological feat...

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Detalles Bibliográficos
Autores principales: Kawai, Takashi, Nyuya, Akihiro, Mori, Yoshiko, Tanaka, Takehiro, Tanioka, Hiroaki, Yasui, Kazuya, Toshima, Toshiaki, Taniguchi, Fumitaka, Shigeyasu, Kunitoshi, Umeda, Yuzo, Fujiwara, Toshiyoshi, Okawaki, Makoto, Yamaguchi, Yoshiyuki, Goel, Ajay, Nagasaka, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146650/
https://www.ncbi.nlm.nih.gov/pubmed/34034807
http://dx.doi.org/10.1186/s13148-021-01104-7

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