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Novel App-Based Portable Spirometer for the Early Detection of COPD

Chronic obstructive pulmonary disease (COPD) is preventable and treatable. However, many patients remain undiagnosed and untreated due to the underutilization or unavailability of spirometers. Accordingly, we used Spirobank Smart, an app-based spirometer, for facilitating the early detection of COPD...

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Autores principales: Lin, Ching-Hsiung, Cheng, Shih-Lung, Wang, Hao-Chien, Hsu, Wu-Huei, Lee, Kang-Yun, Perng, Diahn-Warng, Lin, Hen-I., Lin, Ming-Shian, Tsai, Jong-Rung, Wang, Chin-Chou, Lin, Sheng-Hao, Wang, Cheng-Yi, Chen, Chiung-Zuei, Yang, Tsung-Ming, Liu, Ching-Lung, Wang, Tsai-Yu, Lin, Meng-Chih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146797/
https://www.ncbi.nlm.nih.gov/pubmed/33925463
http://dx.doi.org/10.3390/diagnostics11050785
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author Lin, Ching-Hsiung
Cheng, Shih-Lung
Wang, Hao-Chien
Hsu, Wu-Huei
Lee, Kang-Yun
Perng, Diahn-Warng
Lin, Hen-I.
Lin, Ming-Shian
Tsai, Jong-Rung
Wang, Chin-Chou
Lin, Sheng-Hao
Wang, Cheng-Yi
Chen, Chiung-Zuei
Yang, Tsung-Ming
Liu, Ching-Lung
Wang, Tsai-Yu
Lin, Meng-Chih
author_facet Lin, Ching-Hsiung
Cheng, Shih-Lung
Wang, Hao-Chien
Hsu, Wu-Huei
Lee, Kang-Yun
Perng, Diahn-Warng
Lin, Hen-I.
Lin, Ming-Shian
Tsai, Jong-Rung
Wang, Chin-Chou
Lin, Sheng-Hao
Wang, Cheng-Yi
Chen, Chiung-Zuei
Yang, Tsung-Ming
Liu, Ching-Lung
Wang, Tsai-Yu
Lin, Meng-Chih
author_sort Lin, Ching-Hsiung
collection PubMed
description Chronic obstructive pulmonary disease (COPD) is preventable and treatable. However, many patients remain undiagnosed and untreated due to the underutilization or unavailability of spirometers. Accordingly, we used Spirobank Smart, an app-based spirometer, for facilitating the early detection of COPD in outpatient clinics. This prospective study recruited individuals who were at risk of COPD (i.e., with age of ≥40 years, ≥10 pack-years of smoking, and at least one respiratory symptoms) but had no previous COPD diagnosis. Eligible participants were examined with Spirobank Smart and then underwent confirmatory spirometry (performed using a diagnostic spirometer), regardless of their Spirobank Smart test results. COPD was defined and confirmed using the postbronchodilator forced expiratory volume in 1 s/forced vital capacity values of <0.70 as measured by confirmatory spirometry. A total of 767 participants were enrolled and examined using Spirobank Smart; 370 participants (94.3% men, mean age of 60.9 years and mean 42.6 pack-years of smoking) underwent confirmatory spirometry. Confirmatory spirometry identified COPD in 103 participants (27.8%). At the optimal cutoff point of 0.74 that was determined using Spirobank Smart for COPD diagnosis, the area under the receiver operating characteristic was 0.903 (95% confidence interval (CI) = 0.860–0.947). Multivariate logistic regression revealed that participants who have an FEV(1)/FVC ratio of <74% that was determined using Spirobank Smart (odds ratio (OR) = 58.58, 95% CI = 27.29–125.75) and old age (OR = 3.23, 95% CI = 1.04–10.07 for 60 ≤ age < 65; OR = 5.82, 95% CI = 2.22–15.27 for age ≥ 65) had a higher risk of COPD. The Spirobank Smart is a simple and adequate tool for early COPD detection in outpatient clinics. Early diagnosis and appropriate therapy based on GOLD guidelines can positively influence respiratory symptoms and quality of life.
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spelling pubmed-81467972021-05-26 Novel App-Based Portable Spirometer for the Early Detection of COPD Lin, Ching-Hsiung Cheng, Shih-Lung Wang, Hao-Chien Hsu, Wu-Huei Lee, Kang-Yun Perng, Diahn-Warng Lin, Hen-I. Lin, Ming-Shian Tsai, Jong-Rung Wang, Chin-Chou Lin, Sheng-Hao Wang, Cheng-Yi Chen, Chiung-Zuei Yang, Tsung-Ming Liu, Ching-Lung Wang, Tsai-Yu Lin, Meng-Chih Diagnostics (Basel) Article Chronic obstructive pulmonary disease (COPD) is preventable and treatable. However, many patients remain undiagnosed and untreated due to the underutilization or unavailability of spirometers. Accordingly, we used Spirobank Smart, an app-based spirometer, for facilitating the early detection of COPD in outpatient clinics. This prospective study recruited individuals who were at risk of COPD (i.e., with age of ≥40 years, ≥10 pack-years of smoking, and at least one respiratory symptoms) but had no previous COPD diagnosis. Eligible participants were examined with Spirobank Smart and then underwent confirmatory spirometry (performed using a diagnostic spirometer), regardless of their Spirobank Smart test results. COPD was defined and confirmed using the postbronchodilator forced expiratory volume in 1 s/forced vital capacity values of <0.70 as measured by confirmatory spirometry. A total of 767 participants were enrolled and examined using Spirobank Smart; 370 participants (94.3% men, mean age of 60.9 years and mean 42.6 pack-years of smoking) underwent confirmatory spirometry. Confirmatory spirometry identified COPD in 103 participants (27.8%). At the optimal cutoff point of 0.74 that was determined using Spirobank Smart for COPD diagnosis, the area under the receiver operating characteristic was 0.903 (95% confidence interval (CI) = 0.860–0.947). Multivariate logistic regression revealed that participants who have an FEV(1)/FVC ratio of <74% that was determined using Spirobank Smart (odds ratio (OR) = 58.58, 95% CI = 27.29–125.75) and old age (OR = 3.23, 95% CI = 1.04–10.07 for 60 ≤ age < 65; OR = 5.82, 95% CI = 2.22–15.27 for age ≥ 65) had a higher risk of COPD. The Spirobank Smart is a simple and adequate tool for early COPD detection in outpatient clinics. Early diagnosis and appropriate therapy based on GOLD guidelines can positively influence respiratory symptoms and quality of life. MDPI 2021-04-27 /pmc/articles/PMC8146797/ /pubmed/33925463 http://dx.doi.org/10.3390/diagnostics11050785 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lin, Ching-Hsiung
Cheng, Shih-Lung
Wang, Hao-Chien
Hsu, Wu-Huei
Lee, Kang-Yun
Perng, Diahn-Warng
Lin, Hen-I.
Lin, Ming-Shian
Tsai, Jong-Rung
Wang, Chin-Chou
Lin, Sheng-Hao
Wang, Cheng-Yi
Chen, Chiung-Zuei
Yang, Tsung-Ming
Liu, Ching-Lung
Wang, Tsai-Yu
Lin, Meng-Chih
Novel App-Based Portable Spirometer for the Early Detection of COPD
title Novel App-Based Portable Spirometer for the Early Detection of COPD
title_full Novel App-Based Portable Spirometer for the Early Detection of COPD
title_fullStr Novel App-Based Portable Spirometer for the Early Detection of COPD
title_full_unstemmed Novel App-Based Portable Spirometer for the Early Detection of COPD
title_short Novel App-Based Portable Spirometer for the Early Detection of COPD
title_sort novel app-based portable spirometer for the early detection of copd
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146797/
https://www.ncbi.nlm.nih.gov/pubmed/33925463
http://dx.doi.org/10.3390/diagnostics11050785
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