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Nanocomposite Membrane Scaffolds for Cell Function Maintaining for Biomedical Purposes
Nanocomposite multilayered membrane coatings have been widely used experimentally to enhance biomedical materials surfaces. By the selection of reliable components, such systems are functionalized to be adjusted to specific purposes. As metal nanoparticles can reduce bacterial cell adhesion, the ide...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146798/ https://www.ncbi.nlm.nih.gov/pubmed/33922581 http://dx.doi.org/10.3390/nano11051094 |
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author | Drabik, Monika Grzeczkowicz, Anna Bącal, Paweł Kwiatkowska, Angelika Strawski, Marcin Antosiak-Iwańska, Magdalena Kazimierczak, Beata Godlewska, Ewa Granicka, Ludomira H. |
author_facet | Drabik, Monika Grzeczkowicz, Anna Bącal, Paweł Kwiatkowska, Angelika Strawski, Marcin Antosiak-Iwańska, Magdalena Kazimierczak, Beata Godlewska, Ewa Granicka, Ludomira H. |
author_sort | Drabik, Monika |
collection | PubMed |
description | Nanocomposite multilayered membrane coatings have been widely used experimentally to enhance biomedical materials surfaces. By the selection of reliable components, such systems are functionalized to be adjusted to specific purposes. As metal nanoparticles can reduce bacterial cell adhesion, the idea of using gold and silver nanoparticles of unique antimicrobial properties within membrane structure is outstandingly interesting considering dressings facilitating wound healing. The study was aimed to explore the interface between eukaryotic cells and wound dressing materials containing various nanoelements. The proposed systems are based on polyethyleneimine and hydroxyapatite thin layers incorporating metallic nanoparticles (silver or gold). To examine the structure of designed materials scanning electron and transmission electron microscopies were applied. Moreover, Fourier-transform infrared and energy-dispersive X-ray spectroscopies were used. Additionally, water contact angles of the designed membranes and their transport properties were estimated. The functioning of human fibroblasts was examined via flow cytometry to assess the biocompatibility of developed shells in the aspect of their cytotoxicity. The results indicated that designed nanocomposite membrane scaffolds support eukaryotic cells’ functioning, confirming that the elaborated systems might be recommended as wound healing materials. |
format | Online Article Text |
id | pubmed-8146798 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81467982021-05-26 Nanocomposite Membrane Scaffolds for Cell Function Maintaining for Biomedical Purposes Drabik, Monika Grzeczkowicz, Anna Bącal, Paweł Kwiatkowska, Angelika Strawski, Marcin Antosiak-Iwańska, Magdalena Kazimierczak, Beata Godlewska, Ewa Granicka, Ludomira H. Nanomaterials (Basel) Article Nanocomposite multilayered membrane coatings have been widely used experimentally to enhance biomedical materials surfaces. By the selection of reliable components, such systems are functionalized to be adjusted to specific purposes. As metal nanoparticles can reduce bacterial cell adhesion, the idea of using gold and silver nanoparticles of unique antimicrobial properties within membrane structure is outstandingly interesting considering dressings facilitating wound healing. The study was aimed to explore the interface between eukaryotic cells and wound dressing materials containing various nanoelements. The proposed systems are based on polyethyleneimine and hydroxyapatite thin layers incorporating metallic nanoparticles (silver or gold). To examine the structure of designed materials scanning electron and transmission electron microscopies were applied. Moreover, Fourier-transform infrared and energy-dispersive X-ray spectroscopies were used. Additionally, water contact angles of the designed membranes and their transport properties were estimated. The functioning of human fibroblasts was examined via flow cytometry to assess the biocompatibility of developed shells in the aspect of their cytotoxicity. The results indicated that designed nanocomposite membrane scaffolds support eukaryotic cells’ functioning, confirming that the elaborated systems might be recommended as wound healing materials. MDPI 2021-04-23 /pmc/articles/PMC8146798/ /pubmed/33922581 http://dx.doi.org/10.3390/nano11051094 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Drabik, Monika Grzeczkowicz, Anna Bącal, Paweł Kwiatkowska, Angelika Strawski, Marcin Antosiak-Iwańska, Magdalena Kazimierczak, Beata Godlewska, Ewa Granicka, Ludomira H. Nanocomposite Membrane Scaffolds for Cell Function Maintaining for Biomedical Purposes |
title | Nanocomposite Membrane Scaffolds for Cell Function Maintaining for Biomedical Purposes |
title_full | Nanocomposite Membrane Scaffolds for Cell Function Maintaining for Biomedical Purposes |
title_fullStr | Nanocomposite Membrane Scaffolds for Cell Function Maintaining for Biomedical Purposes |
title_full_unstemmed | Nanocomposite Membrane Scaffolds for Cell Function Maintaining for Biomedical Purposes |
title_short | Nanocomposite Membrane Scaffolds for Cell Function Maintaining for Biomedical Purposes |
title_sort | nanocomposite membrane scaffolds for cell function maintaining for biomedical purposes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146798/ https://www.ncbi.nlm.nih.gov/pubmed/33922581 http://dx.doi.org/10.3390/nano11051094 |
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