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Efferocytosis Mediated Modulation of Injury after Neonatal Brain Hypoxia-Ischemia
Neonatal brain hypoxia-ischemia (HI) is a leading cause of morbidity and long-term disabilities in children. While we have made significant progress in describing HI mechanisms, the limited therapies currently offered for HI treatment in the clinical setting stress the importance of discovering new...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146813/ https://www.ncbi.nlm.nih.gov/pubmed/33925299 http://dx.doi.org/10.3390/cells10051025 |
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author | Mike, Jana Krystofova Ferriero, Donna Marie |
author_facet | Mike, Jana Krystofova Ferriero, Donna Marie |
author_sort | Mike, Jana Krystofova |
collection | PubMed |
description | Neonatal brain hypoxia-ischemia (HI) is a leading cause of morbidity and long-term disabilities in children. While we have made significant progress in describing HI mechanisms, the limited therapies currently offered for HI treatment in the clinical setting stress the importance of discovering new targetable pathways. Efferocytosis is an immunoregulatory and homeostatic process of clearance of apoptotic cells (AC) and cellular debris, best described in the brain during neurodevelopment. The therapeutic potential of stimulating defective efferocytosis has been recognized in neurodegenerative diseases. In this review, we will explore the involvement of efferocytosis after a stroke and HI as a promising target for new HI therapies. |
format | Online Article Text |
id | pubmed-8146813 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81468132021-05-26 Efferocytosis Mediated Modulation of Injury after Neonatal Brain Hypoxia-Ischemia Mike, Jana Krystofova Ferriero, Donna Marie Cells Review Neonatal brain hypoxia-ischemia (HI) is a leading cause of morbidity and long-term disabilities in children. While we have made significant progress in describing HI mechanisms, the limited therapies currently offered for HI treatment in the clinical setting stress the importance of discovering new targetable pathways. Efferocytosis is an immunoregulatory and homeostatic process of clearance of apoptotic cells (AC) and cellular debris, best described in the brain during neurodevelopment. The therapeutic potential of stimulating defective efferocytosis has been recognized in neurodegenerative diseases. In this review, we will explore the involvement of efferocytosis after a stroke and HI as a promising target for new HI therapies. MDPI 2021-04-27 /pmc/articles/PMC8146813/ /pubmed/33925299 http://dx.doi.org/10.3390/cells10051025 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mike, Jana Krystofova Ferriero, Donna Marie Efferocytosis Mediated Modulation of Injury after Neonatal Brain Hypoxia-Ischemia |
title | Efferocytosis Mediated Modulation of Injury after Neonatal Brain Hypoxia-Ischemia |
title_full | Efferocytosis Mediated Modulation of Injury after Neonatal Brain Hypoxia-Ischemia |
title_fullStr | Efferocytosis Mediated Modulation of Injury after Neonatal Brain Hypoxia-Ischemia |
title_full_unstemmed | Efferocytosis Mediated Modulation of Injury after Neonatal Brain Hypoxia-Ischemia |
title_short | Efferocytosis Mediated Modulation of Injury after Neonatal Brain Hypoxia-Ischemia |
title_sort | efferocytosis mediated modulation of injury after neonatal brain hypoxia-ischemia |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146813/ https://www.ncbi.nlm.nih.gov/pubmed/33925299 http://dx.doi.org/10.3390/cells10051025 |
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