Cargando…

Efferocytosis Mediated Modulation of Injury after Neonatal Brain Hypoxia-Ischemia

Neonatal brain hypoxia-ischemia (HI) is a leading cause of morbidity and long-term disabilities in children. While we have made significant progress in describing HI mechanisms, the limited therapies currently offered for HI treatment in the clinical setting stress the importance of discovering new...

Descripción completa

Detalles Bibliográficos
Autores principales: Mike, Jana Krystofova, Ferriero, Donna Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146813/
https://www.ncbi.nlm.nih.gov/pubmed/33925299
http://dx.doi.org/10.3390/cells10051025
_version_ 1783697484130811904
author Mike, Jana Krystofova
Ferriero, Donna Marie
author_facet Mike, Jana Krystofova
Ferriero, Donna Marie
author_sort Mike, Jana Krystofova
collection PubMed
description Neonatal brain hypoxia-ischemia (HI) is a leading cause of morbidity and long-term disabilities in children. While we have made significant progress in describing HI mechanisms, the limited therapies currently offered for HI treatment in the clinical setting stress the importance of discovering new targetable pathways. Efferocytosis is an immunoregulatory and homeostatic process of clearance of apoptotic cells (AC) and cellular debris, best described in the brain during neurodevelopment. The therapeutic potential of stimulating defective efferocytosis has been recognized in neurodegenerative diseases. In this review, we will explore the involvement of efferocytosis after a stroke and HI as a promising target for new HI therapies.
format Online
Article
Text
id pubmed-8146813
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-81468132021-05-26 Efferocytosis Mediated Modulation of Injury after Neonatal Brain Hypoxia-Ischemia Mike, Jana Krystofova Ferriero, Donna Marie Cells Review Neonatal brain hypoxia-ischemia (HI) is a leading cause of morbidity and long-term disabilities in children. While we have made significant progress in describing HI mechanisms, the limited therapies currently offered for HI treatment in the clinical setting stress the importance of discovering new targetable pathways. Efferocytosis is an immunoregulatory and homeostatic process of clearance of apoptotic cells (AC) and cellular debris, best described in the brain during neurodevelopment. The therapeutic potential of stimulating defective efferocytosis has been recognized in neurodegenerative diseases. In this review, we will explore the involvement of efferocytosis after a stroke and HI as a promising target for new HI therapies. MDPI 2021-04-27 /pmc/articles/PMC8146813/ /pubmed/33925299 http://dx.doi.org/10.3390/cells10051025 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mike, Jana Krystofova
Ferriero, Donna Marie
Efferocytosis Mediated Modulation of Injury after Neonatal Brain Hypoxia-Ischemia
title Efferocytosis Mediated Modulation of Injury after Neonatal Brain Hypoxia-Ischemia
title_full Efferocytosis Mediated Modulation of Injury after Neonatal Brain Hypoxia-Ischemia
title_fullStr Efferocytosis Mediated Modulation of Injury after Neonatal Brain Hypoxia-Ischemia
title_full_unstemmed Efferocytosis Mediated Modulation of Injury after Neonatal Brain Hypoxia-Ischemia
title_short Efferocytosis Mediated Modulation of Injury after Neonatal Brain Hypoxia-Ischemia
title_sort efferocytosis mediated modulation of injury after neonatal brain hypoxia-ischemia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146813/
https://www.ncbi.nlm.nih.gov/pubmed/33925299
http://dx.doi.org/10.3390/cells10051025
work_keys_str_mv AT mikejanakrystofova efferocytosismediatedmodulationofinjuryafterneonatalbrainhypoxiaischemia
AT ferrierodonnamarie efferocytosismediatedmodulationofinjuryafterneonatalbrainhypoxiaischemia