Pharmacology, Physiology and Genetics of the Neuropeptide S System

The Neuropeptide S (NPS) system is a rather ‘young’ transmitter system that was discovered and functionally described less than 20 years ago. This review highlights the progress that has been made in elucidating its pharmacology, anatomical distribution, and functional involvement in a variety of ph...

Descripción completa

Detalles Bibliográficos
Autores principales: Reinscheid, Rainer K., Ruzza, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146834/
https://www.ncbi.nlm.nih.gov/pubmed/33922620
http://dx.doi.org/10.3390/ph14050401
_version_ 1783697488887152640
author Reinscheid, Rainer K.
Ruzza, Chiara
author_facet Reinscheid, Rainer K.
Ruzza, Chiara
author_sort Reinscheid, Rainer K.
collection PubMed
description The Neuropeptide S (NPS) system is a rather ‘young’ transmitter system that was discovered and functionally described less than 20 years ago. This review highlights the progress that has been made in elucidating its pharmacology, anatomical distribution, and functional involvement in a variety of physiological effects, including behavior and immune functions. Early on, genetic variations of the human NPS receptor (NPSR1) have attracted attention and we summarize current hypotheses of genetic linkage with disease and human behaviors. Finally, we review the therapeutic potential of future drugs modulating NPS signaling. This review serves as an introduction to the broad collection of original research papers and reviews from experts in the field that are presented in this Special Issue.
format Online
Article
Text
id pubmed-8146834
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-81468342021-05-26 Pharmacology, Physiology and Genetics of the Neuropeptide S System Reinscheid, Rainer K. Ruzza, Chiara Pharmaceuticals (Basel) Review The Neuropeptide S (NPS) system is a rather ‘young’ transmitter system that was discovered and functionally described less than 20 years ago. This review highlights the progress that has been made in elucidating its pharmacology, anatomical distribution, and functional involvement in a variety of physiological effects, including behavior and immune functions. Early on, genetic variations of the human NPS receptor (NPSR1) have attracted attention and we summarize current hypotheses of genetic linkage with disease and human behaviors. Finally, we review the therapeutic potential of future drugs modulating NPS signaling. This review serves as an introduction to the broad collection of original research papers and reviews from experts in the field that are presented in this Special Issue. MDPI 2021-04-23 /pmc/articles/PMC8146834/ /pubmed/33922620 http://dx.doi.org/10.3390/ph14050401 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Reinscheid, Rainer K.
Ruzza, Chiara
Pharmacology, Physiology and Genetics of the Neuropeptide S System
title Pharmacology, Physiology and Genetics of the Neuropeptide S System
title_full Pharmacology, Physiology and Genetics of the Neuropeptide S System
title_fullStr Pharmacology, Physiology and Genetics of the Neuropeptide S System
title_full_unstemmed Pharmacology, Physiology and Genetics of the Neuropeptide S System
title_short Pharmacology, Physiology and Genetics of the Neuropeptide S System
title_sort pharmacology, physiology and genetics of the neuropeptide s system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146834/
https://www.ncbi.nlm.nih.gov/pubmed/33922620
http://dx.doi.org/10.3390/ph14050401
work_keys_str_mv AT reinscheidrainerk pharmacologyphysiologyandgeneticsoftheneuropeptidessystem
AT ruzzachiara pharmacologyphysiologyandgeneticsoftheneuropeptidessystem

Ejemplares similares