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Pharmacology, Physiology and Genetics of the Neuropeptide S System
The Neuropeptide S (NPS) system is a rather ‘young’ transmitter system that was discovered and functionally described less than 20 years ago. This review highlights the progress that has been made in elucidating its pharmacology, anatomical distribution, and functional involvement in a variety of ph...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146834/ https://www.ncbi.nlm.nih.gov/pubmed/33922620 http://dx.doi.org/10.3390/ph14050401 |
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author | Reinscheid, Rainer K. Ruzza, Chiara |
author_facet | Reinscheid, Rainer K. Ruzza, Chiara |
author_sort | Reinscheid, Rainer K. |
collection | PubMed |
description | The Neuropeptide S (NPS) system is a rather ‘young’ transmitter system that was discovered and functionally described less than 20 years ago. This review highlights the progress that has been made in elucidating its pharmacology, anatomical distribution, and functional involvement in a variety of physiological effects, including behavior and immune functions. Early on, genetic variations of the human NPS receptor (NPSR1) have attracted attention and we summarize current hypotheses of genetic linkage with disease and human behaviors. Finally, we review the therapeutic potential of future drugs modulating NPS signaling. This review serves as an introduction to the broad collection of original research papers and reviews from experts in the field that are presented in this Special Issue. |
format | Online Article Text |
id | pubmed-8146834 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81468342021-05-26 Pharmacology, Physiology and Genetics of the Neuropeptide S System Reinscheid, Rainer K. Ruzza, Chiara Pharmaceuticals (Basel) Review The Neuropeptide S (NPS) system is a rather ‘young’ transmitter system that was discovered and functionally described less than 20 years ago. This review highlights the progress that has been made in elucidating its pharmacology, anatomical distribution, and functional involvement in a variety of physiological effects, including behavior and immune functions. Early on, genetic variations of the human NPS receptor (NPSR1) have attracted attention and we summarize current hypotheses of genetic linkage with disease and human behaviors. Finally, we review the therapeutic potential of future drugs modulating NPS signaling. This review serves as an introduction to the broad collection of original research papers and reviews from experts in the field that are presented in this Special Issue. MDPI 2021-04-23 /pmc/articles/PMC8146834/ /pubmed/33922620 http://dx.doi.org/10.3390/ph14050401 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Reinscheid, Rainer K. Ruzza, Chiara Pharmacology, Physiology and Genetics of the Neuropeptide S System |
title | Pharmacology, Physiology and Genetics of the Neuropeptide S System |
title_full | Pharmacology, Physiology and Genetics of the Neuropeptide S System |
title_fullStr | Pharmacology, Physiology and Genetics of the Neuropeptide S System |
title_full_unstemmed | Pharmacology, Physiology and Genetics of the Neuropeptide S System |
title_short | Pharmacology, Physiology and Genetics of the Neuropeptide S System |
title_sort | pharmacology, physiology and genetics of the neuropeptide s system |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146834/ https://www.ncbi.nlm.nih.gov/pubmed/33922620 http://dx.doi.org/10.3390/ph14050401 |
work_keys_str_mv | AT reinscheidrainerk pharmacologyphysiologyandgeneticsoftheneuropeptidessystem AT ruzzachiara pharmacologyphysiologyandgeneticsoftheneuropeptidessystem |