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Cutaneous Leishmaniasis in Algeria; Highlight on the Focus of M’Sila

Algeria ranks second after Afghanistan for the incidence of cutaneous leishmaniasis (CL) worldwide. Here, we report a 34-years retrospective analysis of CL in Algeria and focused on the most affected region, the M’Sila province. All 66 cutaneous isolates corresponded to Leishmania (L.) major. Our st...

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Autores principales: Benikhlef, Razika, Aoun, Karim, Boudrissa, Abdelkarim, Ben Abid, Meriem, Cherif, Kamel, Aissi, Wafa, Benrekta, Souad, Boubidi, Said C., Späth, Gerald F., Bouratbine, Aïda, Sereno, Denis, Harrat, Zoubir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146893/
https://www.ncbi.nlm.nih.gov/pubmed/33947003
http://dx.doi.org/10.3390/microorganisms9050962
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author Benikhlef, Razika
Aoun, Karim
Boudrissa, Abdelkarim
Ben Abid, Meriem
Cherif, Kamel
Aissi, Wafa
Benrekta, Souad
Boubidi, Said C.
Späth, Gerald F.
Bouratbine, Aïda
Sereno, Denis
Harrat, Zoubir
author_facet Benikhlef, Razika
Aoun, Karim
Boudrissa, Abdelkarim
Ben Abid, Meriem
Cherif, Kamel
Aissi, Wafa
Benrekta, Souad
Boubidi, Said C.
Späth, Gerald F.
Bouratbine, Aïda
Sereno, Denis
Harrat, Zoubir
author_sort Benikhlef, Razika
collection PubMed
description Algeria ranks second after Afghanistan for the incidence of cutaneous leishmaniasis (CL) worldwide. Here, we report a 34-years retrospective analysis of CL in Algeria and focused on the most affected region, the M’Sila province. All 66 cutaneous isolates corresponded to Leishmania (L.) major. Our study of the sandfly and rodent fauna further highlighted the high density of Phlebotomus papatasi and additional phlebotomine species of medical importance, not previously identified in M’Sila. Wild rodents belonging to nine species were trapped in M’Sila, and Psammomys obesus and Meriones shawi were found infected by L. major. In addition, Leishmania infantum was isolated from two visceral leishmaniasis cases, one dog and its proven vectors (P. perniciosus, P. longicuspis, and P. perfiliewi) inventoried during the survey. The high incidence of CL in the M’Sila province is likely a consequence of the increase in minimum temperatures recorded that constitutes suitable conditions for establishing a high endemicity and leads to an explosive rise in leishmaniases cases in this region. A thorough investigation of the underlying risk factors is urgently needed to detect new cases earlier. All these would improve the preparedness to fight the disease.
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spelling pubmed-81468932021-05-26 Cutaneous Leishmaniasis in Algeria; Highlight on the Focus of M’Sila Benikhlef, Razika Aoun, Karim Boudrissa, Abdelkarim Ben Abid, Meriem Cherif, Kamel Aissi, Wafa Benrekta, Souad Boubidi, Said C. Späth, Gerald F. Bouratbine, Aïda Sereno, Denis Harrat, Zoubir Microorganisms Article Algeria ranks second after Afghanistan for the incidence of cutaneous leishmaniasis (CL) worldwide. Here, we report a 34-years retrospective analysis of CL in Algeria and focused on the most affected region, the M’Sila province. All 66 cutaneous isolates corresponded to Leishmania (L.) major. Our study of the sandfly and rodent fauna further highlighted the high density of Phlebotomus papatasi and additional phlebotomine species of medical importance, not previously identified in M’Sila. Wild rodents belonging to nine species were trapped in M’Sila, and Psammomys obesus and Meriones shawi were found infected by L. major. In addition, Leishmania infantum was isolated from two visceral leishmaniasis cases, one dog and its proven vectors (P. perniciosus, P. longicuspis, and P. perfiliewi) inventoried during the survey. The high incidence of CL in the M’Sila province is likely a consequence of the increase in minimum temperatures recorded that constitutes suitable conditions for establishing a high endemicity and leads to an explosive rise in leishmaniases cases in this region. A thorough investigation of the underlying risk factors is urgently needed to detect new cases earlier. All these would improve the preparedness to fight the disease. MDPI 2021-04-29 /pmc/articles/PMC8146893/ /pubmed/33947003 http://dx.doi.org/10.3390/microorganisms9050962 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Benikhlef, Razika
Aoun, Karim
Boudrissa, Abdelkarim
Ben Abid, Meriem
Cherif, Kamel
Aissi, Wafa
Benrekta, Souad
Boubidi, Said C.
Späth, Gerald F.
Bouratbine, Aïda
Sereno, Denis
Harrat, Zoubir
Cutaneous Leishmaniasis in Algeria; Highlight on the Focus of M’Sila
title Cutaneous Leishmaniasis in Algeria; Highlight on the Focus of M’Sila
title_full Cutaneous Leishmaniasis in Algeria; Highlight on the Focus of M’Sila
title_fullStr Cutaneous Leishmaniasis in Algeria; Highlight on the Focus of M’Sila
title_full_unstemmed Cutaneous Leishmaniasis in Algeria; Highlight on the Focus of M’Sila
title_short Cutaneous Leishmaniasis in Algeria; Highlight on the Focus of M’Sila
title_sort cutaneous leishmaniasis in algeria; highlight on the focus of m’sila
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146893/
https://www.ncbi.nlm.nih.gov/pubmed/33947003
http://dx.doi.org/10.3390/microorganisms9050962
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