Genetic Determinants in a Critical Domain of NS5A Correlate with Hepatocellular Carcinoma in Cirrhotic Patients Infected with HCV Genotype 1b

HCV is an important cause of hepatocellular carcinoma (HCC). HCV NS5A domain-1 interacts with cellular proteins inducing pro-oncogenic pathways. Thus, we explore genetic variations in NS5A domain-1 and their association with HCC, by analyzing 188 NS5A sequences from HCV genotype-1b infected DAA-naïv...

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Detalles Bibliográficos
Autores principales: Alkhatib, Mohammad, Di Maio, Velia Chiara, De Murtas, Valentina, Polilli, Ennio, Milana, Martina, Teti, Elisabetta, Fiorentino, Gianluca, Calvaruso, Vincenza, Barbaliscia, Silvia, Bertoli, Ada, Scutari, Rossana, Carioti, Luca, Cento, Valeria, Santoro, Maria Mercedes, Orro, Alessandro, Maida, Ivana, Lenci, Ilaria, Sarmati, Loredana, Craxì, Antonio, Pasquazzi, Caterina, Parruti, Giustino, Babudieri, Sergio, Milanesi, Luciano, Andreoni, Massimo, Angelico, Mario, Perno, Carlo Federico, Ceccherini-Silberstein, Francesca, Svicher, Valentina, Salpini, Romina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146897/
https://www.ncbi.nlm.nih.gov/pubmed/33922732
http://dx.doi.org/10.3390/v13050743

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146897/
https://www.ncbi.nlm.nih.gov/pubmed/33922732
http://dx.doi.org/10.3390/v13050743

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