Cargando…

Measurements of Serum Mac-2-Binding Protein Glycosylation Isomer and Shear Wave Velocity in Health Checkups Are Useful in Screening for Non-Alcoholic Steatohepatitis

Liver-related mortality rates in patients with non-alcoholic steatohepatitis (NASH) increase with advancing liver fibrosis stage. The present study aimed to elucidate whether adding non-invasive liver fibrosis tests to a comprehensive health checkup system is useful for NASH screening. Both serum Ma...

Descripción completa

Detalles Bibliográficos
Autores principales: Tamai, Hideyuki, Okamura, Jumpei, Ohoshi, Takashi, Wakasaki, Hisao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146964/
https://www.ncbi.nlm.nih.gov/pubmed/33946842
http://dx.doi.org/10.3390/healthcare9050523
_version_ 1783697519854747648
author Tamai, Hideyuki
Okamura, Jumpei
Ohoshi, Takashi
Wakasaki, Hisao
author_facet Tamai, Hideyuki
Okamura, Jumpei
Ohoshi, Takashi
Wakasaki, Hisao
author_sort Tamai, Hideyuki
collection PubMed
description Liver-related mortality rates in patients with non-alcoholic steatohepatitis (NASH) increase with advancing liver fibrosis stage. The present study aimed to elucidate whether adding non-invasive liver fibrosis tests to a comprehensive health checkup system is useful for NASH screening. Both serum Mac-2-binding protein glycosylation isomer (M2BPGi) and point shear wave elastography (pSWE) using ultrasonography were performed for 483 health checkup subjects who consented to participate in this prospective study. Outcomes in positive subjects were surveyed 1 year later. Eighty-eight subjects (18%) showed positive results for at least one liver fibrosis test, with 63 subjects positive for pSWE, 33 subjects positive for M2BPGi, and 72 subjects showing no significant elevation of liver enzymes. The secondary consultation rate for positive subjects was 52% (46/88). However, as 15 of those 46 subjects visited a non-liver-specialist and could not undergo detailed examination, the secondary examination rate was only 35% (31/88). For the 31 subjects who received secondary examination, NASH was diagnosed in 14 subjects, other chronic liver disease (CLD) in 6 subjects, and no CLD in 11 subjects. Additional liver fibrosis tests using M2BPGi and pSWE appear useful in health checkups when screening for CLD, especially for NASH.
format Online
Article
Text
id pubmed-8146964
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-81469642021-05-26 Measurements of Serum Mac-2-Binding Protein Glycosylation Isomer and Shear Wave Velocity in Health Checkups Are Useful in Screening for Non-Alcoholic Steatohepatitis Tamai, Hideyuki Okamura, Jumpei Ohoshi, Takashi Wakasaki, Hisao Healthcare (Basel) Article Liver-related mortality rates in patients with non-alcoholic steatohepatitis (NASH) increase with advancing liver fibrosis stage. The present study aimed to elucidate whether adding non-invasive liver fibrosis tests to a comprehensive health checkup system is useful for NASH screening. Both serum Mac-2-binding protein glycosylation isomer (M2BPGi) and point shear wave elastography (pSWE) using ultrasonography were performed for 483 health checkup subjects who consented to participate in this prospective study. Outcomes in positive subjects were surveyed 1 year later. Eighty-eight subjects (18%) showed positive results for at least one liver fibrosis test, with 63 subjects positive for pSWE, 33 subjects positive for M2BPGi, and 72 subjects showing no significant elevation of liver enzymes. The secondary consultation rate for positive subjects was 52% (46/88). However, as 15 of those 46 subjects visited a non-liver-specialist and could not undergo detailed examination, the secondary examination rate was only 35% (31/88). For the 31 subjects who received secondary examination, NASH was diagnosed in 14 subjects, other chronic liver disease (CLD) in 6 subjects, and no CLD in 11 subjects. Additional liver fibrosis tests using M2BPGi and pSWE appear useful in health checkups when screening for CLD, especially for NASH. MDPI 2021-04-29 /pmc/articles/PMC8146964/ /pubmed/33946842 http://dx.doi.org/10.3390/healthcare9050523 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tamai, Hideyuki
Okamura, Jumpei
Ohoshi, Takashi
Wakasaki, Hisao
Measurements of Serum Mac-2-Binding Protein Glycosylation Isomer and Shear Wave Velocity in Health Checkups Are Useful in Screening for Non-Alcoholic Steatohepatitis
title Measurements of Serum Mac-2-Binding Protein Glycosylation Isomer and Shear Wave Velocity in Health Checkups Are Useful in Screening for Non-Alcoholic Steatohepatitis
title_full Measurements of Serum Mac-2-Binding Protein Glycosylation Isomer and Shear Wave Velocity in Health Checkups Are Useful in Screening for Non-Alcoholic Steatohepatitis
title_fullStr Measurements of Serum Mac-2-Binding Protein Glycosylation Isomer and Shear Wave Velocity in Health Checkups Are Useful in Screening for Non-Alcoholic Steatohepatitis
title_full_unstemmed Measurements of Serum Mac-2-Binding Protein Glycosylation Isomer and Shear Wave Velocity in Health Checkups Are Useful in Screening for Non-Alcoholic Steatohepatitis
title_short Measurements of Serum Mac-2-Binding Protein Glycosylation Isomer and Shear Wave Velocity in Health Checkups Are Useful in Screening for Non-Alcoholic Steatohepatitis
title_sort measurements of serum mac-2-binding protein glycosylation isomer and shear wave velocity in health checkups are useful in screening for non-alcoholic steatohepatitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146964/
https://www.ncbi.nlm.nih.gov/pubmed/33946842
http://dx.doi.org/10.3390/healthcare9050523
work_keys_str_mv AT tamaihideyuki measurementsofserummac2bindingproteinglycosylationisomerandshearwavevelocityinhealthcheckupsareusefulinscreeningfornonalcoholicsteatohepatitis
AT okamurajumpei measurementsofserummac2bindingproteinglycosylationisomerandshearwavevelocityinhealthcheckupsareusefulinscreeningfornonalcoholicsteatohepatitis
AT ohoshitakashi measurementsofserummac2bindingproteinglycosylationisomerandshearwavevelocityinhealthcheckupsareusefulinscreeningfornonalcoholicsteatohepatitis
AT wakasakihisao measurementsofserummac2bindingproteinglycosylationisomerandshearwavevelocityinhealthcheckupsareusefulinscreeningfornonalcoholicsteatohepatitis