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An Arrhythmic Mutation E7K Facilitates TRPM4 Channel Activation via Enhanced PIP(2) Interaction
A Ca(2+)-activated monovalent cation-selective TRPM4 channel is abundantly expressed in the heart. Recently, a single gain-of-function mutation identified in the distal N-terminus of the human TRPM4 channel (Glu(5) to Lys(5); E7K) was found to be arrhythmogenic because of enhanced cell membrane expr...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8146980/ https://www.ncbi.nlm.nih.gov/pubmed/33922380 http://dx.doi.org/10.3390/cells10050983 |