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Dynamic Functional Network Connectivity Changes Associated with fMRI Neurofeedback of Right Premotor Cortex

Neurofeedback of real-time functional magnetic resonance imaging (rtfMRI) can enable people to self-regulate motor-related brain regions and lead to alteration of motor performance and functional connectivity (FC) underlying motor execution tasks. Numerous studies suggest that FCs dynamically fluctu...

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Autores principales: Long, Zhiying, Guo, Zhaoxi, Guo, Zhitao, Zhang, Hang, Yao, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147082/
https://www.ncbi.nlm.nih.gov/pubmed/33946251
http://dx.doi.org/10.3390/brainsci11050582
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author Long, Zhiying
Guo, Zhaoxi
Guo, Zhitao
Zhang, Hang
Yao, Li
author_facet Long, Zhiying
Guo, Zhaoxi
Guo, Zhitao
Zhang, Hang
Yao, Li
author_sort Long, Zhiying
collection PubMed
description Neurofeedback of real-time functional magnetic resonance imaging (rtfMRI) can enable people to self-regulate motor-related brain regions and lead to alteration of motor performance and functional connectivity (FC) underlying motor execution tasks. Numerous studies suggest that FCs dynamically fluctuate over time. However, little is known about the impact of neurofeedback training of the motor-related region on the dynamic characteristics of FC underlying motor execution tasks. This study aims to investigate the mechanism of self-regulation of the right premotor area (PMA) on the underlying dynamic functional network connectivity (DFNC) of motor execution (ME) tasks and reveal the relationship between DFNC, training effect, and motor performance. The results indicate that the experimental group spent less time on state 2, with overall weak connections, and more time on state 6, having strong positive connections between motor-related networks than the control group after the training. For the experimental group’s state 2, the mean dwell time after the training showed negative correlation with the tapping frequency and the amount of upregulation of PMA. The findings show that rtfMRI neurofeedback can change the temporal properties of DFNC, and the DFNC changes in state with overall weak connections were associated with the training effect and the improvement in motor performance.
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spelling pubmed-81470822021-05-26 Dynamic Functional Network Connectivity Changes Associated with fMRI Neurofeedback of Right Premotor Cortex Long, Zhiying Guo, Zhaoxi Guo, Zhitao Zhang, Hang Yao, Li Brain Sci Article Neurofeedback of real-time functional magnetic resonance imaging (rtfMRI) can enable people to self-regulate motor-related brain regions and lead to alteration of motor performance and functional connectivity (FC) underlying motor execution tasks. Numerous studies suggest that FCs dynamically fluctuate over time. However, little is known about the impact of neurofeedback training of the motor-related region on the dynamic characteristics of FC underlying motor execution tasks. This study aims to investigate the mechanism of self-regulation of the right premotor area (PMA) on the underlying dynamic functional network connectivity (DFNC) of motor execution (ME) tasks and reveal the relationship between DFNC, training effect, and motor performance. The results indicate that the experimental group spent less time on state 2, with overall weak connections, and more time on state 6, having strong positive connections between motor-related networks than the control group after the training. For the experimental group’s state 2, the mean dwell time after the training showed negative correlation with the tapping frequency and the amount of upregulation of PMA. The findings show that rtfMRI neurofeedback can change the temporal properties of DFNC, and the DFNC changes in state with overall weak connections were associated with the training effect and the improvement in motor performance. MDPI 2021-04-30 /pmc/articles/PMC8147082/ /pubmed/33946251 http://dx.doi.org/10.3390/brainsci11050582 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Long, Zhiying
Guo, Zhaoxi
Guo, Zhitao
Zhang, Hang
Yao, Li
Dynamic Functional Network Connectivity Changes Associated with fMRI Neurofeedback of Right Premotor Cortex
title Dynamic Functional Network Connectivity Changes Associated with fMRI Neurofeedback of Right Premotor Cortex
title_full Dynamic Functional Network Connectivity Changes Associated with fMRI Neurofeedback of Right Premotor Cortex
title_fullStr Dynamic Functional Network Connectivity Changes Associated with fMRI Neurofeedback of Right Premotor Cortex
title_full_unstemmed Dynamic Functional Network Connectivity Changes Associated with fMRI Neurofeedback of Right Premotor Cortex
title_short Dynamic Functional Network Connectivity Changes Associated with fMRI Neurofeedback of Right Premotor Cortex
title_sort dynamic functional network connectivity changes associated with fmri neurofeedback of right premotor cortex
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147082/
https://www.ncbi.nlm.nih.gov/pubmed/33946251
http://dx.doi.org/10.3390/brainsci11050582
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