Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition

Migraine is the sixth most prevalent disease worldwide but the mechanisms that underlie migraine chronicity are poorly understood. Cytoskeletal flexibility is fundamental to neuronal-plasticity and is dependent on dynamic microtubules. Histone-deacetylase-6 (HDAC6) decreases microtubule dynamics by...

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Detalles Bibliográficos
Autores principales: Bertels, Zachariah, Singh, Harinder, Dripps, Isaac, Siegersma, Kendra, Tipton, Alycia F, Witkowski, Wiktor D, Sheets, Zoie, Shah, Pal, Conway, Catherine, Mangutov, Elizaveta, Ao, Mei, Petukhova, Valentina, Karumudi, Bhargava, Petukhov, Pavel A, Baca, Serapio M, Rasenick, Mark M, Pradhan, Amynah A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147088/
https://www.ncbi.nlm.nih.gov/pubmed/33856345
http://dx.doi.org/10.7554/eLife.63076

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