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Spatial and Temporal Distribution of Mycobacterium tuberculosis Complex Infection in Eurasian Badger (Meles meles) and Cattle in Asturias, Spain

SIMPLE SUMMARY: The aim of the present work was to investigate the prevalence, spatial distribution, and temporal distribution of tuberculosis in 673 free-ranging Eurasian badgers (Meles meles) and cattle from Asturias (Atlantic Spain) during a 13-year follow-up. The study objective was to assess th...

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Autores principales: Blanco Vázquez, Cristina, Barral, Thiago Doria, Romero, Beatriz, Queipo, Manuel, Merediz, Isabel, Quirós, Pablo, Armenteros, José Ángel, Juste, Ramón, Domínguez, Lucas, Domínguez, Mercedes, Casais, Rosa, Balseiro, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147139/
https://www.ncbi.nlm.nih.gov/pubmed/33946463
http://dx.doi.org/10.3390/ani11051294
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author Blanco Vázquez, Cristina
Barral, Thiago Doria
Romero, Beatriz
Queipo, Manuel
Merediz, Isabel
Quirós, Pablo
Armenteros, José Ángel
Juste, Ramón
Domínguez, Lucas
Domínguez, Mercedes
Casais, Rosa
Balseiro, Ana
author_facet Blanco Vázquez, Cristina
Barral, Thiago Doria
Romero, Beatriz
Queipo, Manuel
Merediz, Isabel
Quirós, Pablo
Armenteros, José Ángel
Juste, Ramón
Domínguez, Lucas
Domínguez, Mercedes
Casais, Rosa
Balseiro, Ana
author_sort Blanco Vázquez, Cristina
collection PubMed
description SIMPLE SUMMARY: The aim of the present work was to investigate the prevalence, spatial distribution, and temporal distribution of tuberculosis in 673 free-ranging Eurasian badgers (Meles meles) and cattle from Asturias (Atlantic Spain) during a 13-year follow-up. The study objective was to assess the role of badgers as a reservoir of tuberculosis for cattle and other sympatric wild species in the region. During the follow-up, 27/639 badgers (4.23%) were positive for the Mycobacterium tuberculosis complex based on bacterial isolation, while 160/673 (23.77%) were positive based on P22 ELISA. Badger infection was spatially and temporally associated with cattle herd infection. ABSTRACT: The present work investigated the prevalence, spatial distribution, and temporal distribution of tuberculosis (TB) in free-ranging Eurasian badgers (Meles meles) and cattle in Asturias (Atlantic Spain) during a 13-year follow-up. The study objective was to assess the role of badgers as a TB reservoir for cattle and other sympatric wild species in the region. Between 2008 and 2020, 673 badgers (98 trapped and 575 killed in road traffic accidents) in Asturias were necropsied, and their tissue samples were cultured for the Mycobacterium tuberculosis complex (MTC) isolation. Serum samples were tested in an in-house indirect P22 ELISA to detect antibodies against the MTC. In parallel, data on MTC isolation and single intradermal tuberculin test results were extracted for cattle that were tested and culled as part of the Spanish National Program for the Eradication of Bovine TB. A total of 27/639 badgers (4.23%) were positive for MTC based on bacterial isolation, while 160/673 badgers (23.77%) were found to be positive with the P22 ELISA. The rate of seropositivity was higher among adult badgers than subadults. Badger TB status was spatially and temporally associated with cattle TB status. Our results cannot determine the direction of possible interspecies transmission, but they are consistent with the idea that the two hosts may exert infection pressure on each other. This study highlights the importance of the wildlife monitoring of infection and disease during epidemiological interventions in order to optimize outcomes.
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spelling pubmed-81471392021-05-26 Spatial and Temporal Distribution of Mycobacterium tuberculosis Complex Infection in Eurasian Badger (Meles meles) and Cattle in Asturias, Spain Blanco Vázquez, Cristina Barral, Thiago Doria Romero, Beatriz Queipo, Manuel Merediz, Isabel Quirós, Pablo Armenteros, José Ángel Juste, Ramón Domínguez, Lucas Domínguez, Mercedes Casais, Rosa Balseiro, Ana Animals (Basel) Article SIMPLE SUMMARY: The aim of the present work was to investigate the prevalence, spatial distribution, and temporal distribution of tuberculosis in 673 free-ranging Eurasian badgers (Meles meles) and cattle from Asturias (Atlantic Spain) during a 13-year follow-up. The study objective was to assess the role of badgers as a reservoir of tuberculosis for cattle and other sympatric wild species in the region. During the follow-up, 27/639 badgers (4.23%) were positive for the Mycobacterium tuberculosis complex based on bacterial isolation, while 160/673 (23.77%) were positive based on P22 ELISA. Badger infection was spatially and temporally associated with cattle herd infection. ABSTRACT: The present work investigated the prevalence, spatial distribution, and temporal distribution of tuberculosis (TB) in free-ranging Eurasian badgers (Meles meles) and cattle in Asturias (Atlantic Spain) during a 13-year follow-up. The study objective was to assess the role of badgers as a TB reservoir for cattle and other sympatric wild species in the region. Between 2008 and 2020, 673 badgers (98 trapped and 575 killed in road traffic accidents) in Asturias were necropsied, and their tissue samples were cultured for the Mycobacterium tuberculosis complex (MTC) isolation. Serum samples were tested in an in-house indirect P22 ELISA to detect antibodies against the MTC. In parallel, data on MTC isolation and single intradermal tuberculin test results were extracted for cattle that were tested and culled as part of the Spanish National Program for the Eradication of Bovine TB. A total of 27/639 badgers (4.23%) were positive for MTC based on bacterial isolation, while 160/673 badgers (23.77%) were found to be positive with the P22 ELISA. The rate of seropositivity was higher among adult badgers than subadults. Badger TB status was spatially and temporally associated with cattle TB status. Our results cannot determine the direction of possible interspecies transmission, but they are consistent with the idea that the two hosts may exert infection pressure on each other. This study highlights the importance of the wildlife monitoring of infection and disease during epidemiological interventions in order to optimize outcomes. MDPI 2021-04-30 /pmc/articles/PMC8147139/ /pubmed/33946463 http://dx.doi.org/10.3390/ani11051294 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Blanco Vázquez, Cristina
Barral, Thiago Doria
Romero, Beatriz
Queipo, Manuel
Merediz, Isabel
Quirós, Pablo
Armenteros, José Ángel
Juste, Ramón
Domínguez, Lucas
Domínguez, Mercedes
Casais, Rosa
Balseiro, Ana
Spatial and Temporal Distribution of Mycobacterium tuberculosis Complex Infection in Eurasian Badger (Meles meles) and Cattle in Asturias, Spain
title Spatial and Temporal Distribution of Mycobacterium tuberculosis Complex Infection in Eurasian Badger (Meles meles) and Cattle in Asturias, Spain
title_full Spatial and Temporal Distribution of Mycobacterium tuberculosis Complex Infection in Eurasian Badger (Meles meles) and Cattle in Asturias, Spain
title_fullStr Spatial and Temporal Distribution of Mycobacterium tuberculosis Complex Infection in Eurasian Badger (Meles meles) and Cattle in Asturias, Spain
title_full_unstemmed Spatial and Temporal Distribution of Mycobacterium tuberculosis Complex Infection in Eurasian Badger (Meles meles) and Cattle in Asturias, Spain
title_short Spatial and Temporal Distribution of Mycobacterium tuberculosis Complex Infection in Eurasian Badger (Meles meles) and Cattle in Asturias, Spain
title_sort spatial and temporal distribution of mycobacterium tuberculosis complex infection in eurasian badger (meles meles) and cattle in asturias, spain
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147139/
https://www.ncbi.nlm.nih.gov/pubmed/33946463
http://dx.doi.org/10.3390/ani11051294
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