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Sylvatic Canine Morbillivirus in Captive Panthera Highlights Viral Promiscuity and the Need for Better Prevention Strategies
Canine Distemper Virus (CDV) is a multi-host morbillivirus that infects virtually all Carnivora and a few non-human primates. Here we describe a CDV outbreak in an exotic felid rescue center that led to the death of eight felids in the genus Panthera. Similar to domestic dogs and in contrast to prev...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147164/ https://www.ncbi.nlm.nih.gov/pubmed/33946447 http://dx.doi.org/10.3390/pathogens10050544 |
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author | Batista Linhares, Mainity Whiteley, Herbert E. Samuelson, Jonathan P. Hsiao, Shih Hsuan Stern, Adam W. Sprandel, Ian T. Roady, Patrick J. Coleman, David A. Rizzo, Rebecca Froderman, S. Fred Terio, Karen A. |
author_facet | Batista Linhares, Mainity Whiteley, Herbert E. Samuelson, Jonathan P. Hsiao, Shih Hsuan Stern, Adam W. Sprandel, Ian T. Roady, Patrick J. Coleman, David A. Rizzo, Rebecca Froderman, S. Fred Terio, Karen A. |
author_sort | Batista Linhares, Mainity |
collection | PubMed |
description | Canine Distemper Virus (CDV) is a multi-host morbillivirus that infects virtually all Carnivora and a few non-human primates. Here we describe a CDV outbreak in an exotic felid rescue center that led to the death of eight felids in the genus Panthera. Similar to domestic dogs and in contrast to previously described CDV cases in Panthera, severe pneumonia was the primary lesion and no viral antigens or CDV-like lesions were detected in the central nervous system. Four tigers succumbed to opportunistic infections. Viral hemagglutinin (H)-gene sequence was up to 99% similar to strains circulating contemporaneously in regional wildlife. CDV lesions in raccoons and skunk were primarily encephalitis. A few affected felids had at least one previous vaccination for CDV, while most felids at the center were vaccinated during the outbreak. Panthera sharing a fence or enclosure with infected conspecifics had significantly higher chances of getting sick or dying, suggesting tiger-tiger spread was more likely than recurrent spillover. Prior vaccination was incomplete and likely not protective. This outbreak highlights the need for further understanding of CDV epidemiology for species conservation and public health. |
format | Online Article Text |
id | pubmed-8147164 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81471642021-05-26 Sylvatic Canine Morbillivirus in Captive Panthera Highlights Viral Promiscuity and the Need for Better Prevention Strategies Batista Linhares, Mainity Whiteley, Herbert E. Samuelson, Jonathan P. Hsiao, Shih Hsuan Stern, Adam W. Sprandel, Ian T. Roady, Patrick J. Coleman, David A. Rizzo, Rebecca Froderman, S. Fred Terio, Karen A. Pathogens Case Report Canine Distemper Virus (CDV) is a multi-host morbillivirus that infects virtually all Carnivora and a few non-human primates. Here we describe a CDV outbreak in an exotic felid rescue center that led to the death of eight felids in the genus Panthera. Similar to domestic dogs and in contrast to previously described CDV cases in Panthera, severe pneumonia was the primary lesion and no viral antigens or CDV-like lesions were detected in the central nervous system. Four tigers succumbed to opportunistic infections. Viral hemagglutinin (H)-gene sequence was up to 99% similar to strains circulating contemporaneously in regional wildlife. CDV lesions in raccoons and skunk were primarily encephalitis. A few affected felids had at least one previous vaccination for CDV, while most felids at the center were vaccinated during the outbreak. Panthera sharing a fence or enclosure with infected conspecifics had significantly higher chances of getting sick or dying, suggesting tiger-tiger spread was more likely than recurrent spillover. Prior vaccination was incomplete and likely not protective. This outbreak highlights the need for further understanding of CDV epidemiology for species conservation and public health. MDPI 2021-04-30 /pmc/articles/PMC8147164/ /pubmed/33946447 http://dx.doi.org/10.3390/pathogens10050544 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Batista Linhares, Mainity Whiteley, Herbert E. Samuelson, Jonathan P. Hsiao, Shih Hsuan Stern, Adam W. Sprandel, Ian T. Roady, Patrick J. Coleman, David A. Rizzo, Rebecca Froderman, S. Fred Terio, Karen A. Sylvatic Canine Morbillivirus in Captive Panthera Highlights Viral Promiscuity and the Need for Better Prevention Strategies |
title | Sylvatic Canine Morbillivirus in Captive Panthera Highlights Viral Promiscuity and the Need for Better Prevention Strategies |
title_full | Sylvatic Canine Morbillivirus in Captive Panthera Highlights Viral Promiscuity and the Need for Better Prevention Strategies |
title_fullStr | Sylvatic Canine Morbillivirus in Captive Panthera Highlights Viral Promiscuity and the Need for Better Prevention Strategies |
title_full_unstemmed | Sylvatic Canine Morbillivirus in Captive Panthera Highlights Viral Promiscuity and the Need for Better Prevention Strategies |
title_short | Sylvatic Canine Morbillivirus in Captive Panthera Highlights Viral Promiscuity and the Need for Better Prevention Strategies |
title_sort | sylvatic canine morbillivirus in captive panthera highlights viral promiscuity and the need for better prevention strategies |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147164/ https://www.ncbi.nlm.nih.gov/pubmed/33946447 http://dx.doi.org/10.3390/pathogens10050544 |
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