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Dysbiosis and Alzheimer’s Disease: A Role for Chronic Stress?

Alzheimer’s disease (AD) is an incurable, neuropsychiatric, pathological condition that deteriorates the worth of geriatric lives. AD is characterized by aggregated senile amyloid plaques, neurofibrillary tangles, neuronal loss, gliosis, oxidative stress, neurotransmitter dysfunction, and bioenerget...

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Autores principales: Sharma, Vivek Kumar, Singh, Thakur Gurjeet, Garg, Nikhil, Dhiman, Sonia, Gupta, Saurabh, Rahman, Md. Habibur, Najda, Agnieszka, Walasek-Janusz, Magdalena, Kamel, Mohamed, Albadrani, Ghadeer M., Akhtar, Muhammad Furqan, Saleem, Ammara, Altyar, Ahmed E., Abdel-Daim, Mohamed M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147174/
https://www.ncbi.nlm.nih.gov/pubmed/33946488
http://dx.doi.org/10.3390/biom11050678
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author Sharma, Vivek Kumar
Singh, Thakur Gurjeet
Garg, Nikhil
Dhiman, Sonia
Gupta, Saurabh
Rahman, Md. Habibur
Najda, Agnieszka
Walasek-Janusz, Magdalena
Kamel, Mohamed
Albadrani, Ghadeer M.
Akhtar, Muhammad Furqan
Saleem, Ammara
Altyar, Ahmed E.
Abdel-Daim, Mohamed M.
author_facet Sharma, Vivek Kumar
Singh, Thakur Gurjeet
Garg, Nikhil
Dhiman, Sonia
Gupta, Saurabh
Rahman, Md. Habibur
Najda, Agnieszka
Walasek-Janusz, Magdalena
Kamel, Mohamed
Albadrani, Ghadeer M.
Akhtar, Muhammad Furqan
Saleem, Ammara
Altyar, Ahmed E.
Abdel-Daim, Mohamed M.
author_sort Sharma, Vivek Kumar
collection PubMed
description Alzheimer’s disease (AD) is an incurable, neuropsychiatric, pathological condition that deteriorates the worth of geriatric lives. AD is characterized by aggregated senile amyloid plaques, neurofibrillary tangles, neuronal loss, gliosis, oxidative stress, neurotransmitter dysfunction, and bioenergetic deficits. The changes in GIT composition and harmony have been recognized as a decisive and interesting player in neuronal pathologies including AD. Microbiota control and influence the oxidoreductase status, inflammation, immune system, and the endocrine system through which it may have an impact on the cognitive domain. The altered and malfunctioned state of microbiota is associated with minor infections to complicated illnesses that include psychosis and neurodegeneration, and several studies show that microbiota regulates neuronal plasticity and neuronal development. The altered state of microbiota (dysbiosis) may affect behavior, stress response, and cognitive functions. Chronic stress-mediated pathological progression also has a well-defined role that intermingles at various physiological levels and directly impacts the pathological advancement of AD. Chronic stress-modulated alterations affect the well-established pathological markers of AD but also affect the gut–brain axis through the mediation of various downstream signaling mechanisms that modulate the microbial commensals of GIT. The extensive literature reports that chronic stressors affect the composition, metabolic activities, and physiological role of microbiota in various capacities. The present manuscript aims to elucidate mechanistic pathways through which stress induces dysbiosis, which in turn escalates the neuropathological cascade of AD. The stress–dysbiosis axis appears a feasible zone of work in the direction of treatment of AD.
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spelling pubmed-81471742021-05-26 Dysbiosis and Alzheimer’s Disease: A Role for Chronic Stress? Sharma, Vivek Kumar Singh, Thakur Gurjeet Garg, Nikhil Dhiman, Sonia Gupta, Saurabh Rahman, Md. Habibur Najda, Agnieszka Walasek-Janusz, Magdalena Kamel, Mohamed Albadrani, Ghadeer M. Akhtar, Muhammad Furqan Saleem, Ammara Altyar, Ahmed E. Abdel-Daim, Mohamed M. Biomolecules Review Alzheimer’s disease (AD) is an incurable, neuropsychiatric, pathological condition that deteriorates the worth of geriatric lives. AD is characterized by aggregated senile amyloid plaques, neurofibrillary tangles, neuronal loss, gliosis, oxidative stress, neurotransmitter dysfunction, and bioenergetic deficits. The changes in GIT composition and harmony have been recognized as a decisive and interesting player in neuronal pathologies including AD. Microbiota control and influence the oxidoreductase status, inflammation, immune system, and the endocrine system through which it may have an impact on the cognitive domain. The altered and malfunctioned state of microbiota is associated with minor infections to complicated illnesses that include psychosis and neurodegeneration, and several studies show that microbiota regulates neuronal plasticity and neuronal development. The altered state of microbiota (dysbiosis) may affect behavior, stress response, and cognitive functions. Chronic stress-mediated pathological progression also has a well-defined role that intermingles at various physiological levels and directly impacts the pathological advancement of AD. Chronic stress-modulated alterations affect the well-established pathological markers of AD but also affect the gut–brain axis through the mediation of various downstream signaling mechanisms that modulate the microbial commensals of GIT. The extensive literature reports that chronic stressors affect the composition, metabolic activities, and physiological role of microbiota in various capacities. The present manuscript aims to elucidate mechanistic pathways through which stress induces dysbiosis, which in turn escalates the neuropathological cascade of AD. The stress–dysbiosis axis appears a feasible zone of work in the direction of treatment of AD. MDPI 2021-04-30 /pmc/articles/PMC8147174/ /pubmed/33946488 http://dx.doi.org/10.3390/biom11050678 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sharma, Vivek Kumar
Singh, Thakur Gurjeet
Garg, Nikhil
Dhiman, Sonia
Gupta, Saurabh
Rahman, Md. Habibur
Najda, Agnieszka
Walasek-Janusz, Magdalena
Kamel, Mohamed
Albadrani, Ghadeer M.
Akhtar, Muhammad Furqan
Saleem, Ammara
Altyar, Ahmed E.
Abdel-Daim, Mohamed M.
Dysbiosis and Alzheimer’s Disease: A Role for Chronic Stress?
title Dysbiosis and Alzheimer’s Disease: A Role for Chronic Stress?
title_full Dysbiosis and Alzheimer’s Disease: A Role for Chronic Stress?
title_fullStr Dysbiosis and Alzheimer’s Disease: A Role for Chronic Stress?
title_full_unstemmed Dysbiosis and Alzheimer’s Disease: A Role for Chronic Stress?
title_short Dysbiosis and Alzheimer’s Disease: A Role for Chronic Stress?
title_sort dysbiosis and alzheimer’s disease: a role for chronic stress?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147174/
https://www.ncbi.nlm.nih.gov/pubmed/33946488
http://dx.doi.org/10.3390/biom11050678
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