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The Role of Hydrogen Sulfide in Respiratory Diseases

Respiratory diseases are leading causes of death and disability around the globe, with a diverse range of health problems. Treatment of respiratory diseases and infections has been verified to be thought-provoking because of the increasing incidence and mortality rate. Hydrogen sulfide (H(2)S) is on...

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Autores principales: Khattak, Saadullah, Zhang, Qian-Qian, Sarfraz, Muhammad, Muhammad, Pir, Ngowi, Ebenezeri Erasto, Khan, Nazeer Hussain, Rauf, Saqib, Wang, Yi-Zhen, Qi, Hui-Wen, Wang, Di, Afzal, Attia, Ji, Xin-Ying, Wu, Dong-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147381/
https://www.ncbi.nlm.nih.gov/pubmed/34062820
http://dx.doi.org/10.3390/biom11050682
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author Khattak, Saadullah
Zhang, Qian-Qian
Sarfraz, Muhammad
Muhammad, Pir
Ngowi, Ebenezeri Erasto
Khan, Nazeer Hussain
Rauf, Saqib
Wang, Yi-Zhen
Qi, Hui-Wen
Wang, Di
Afzal, Attia
Ji, Xin-Ying
Wu, Dong-Dong
author_facet Khattak, Saadullah
Zhang, Qian-Qian
Sarfraz, Muhammad
Muhammad, Pir
Ngowi, Ebenezeri Erasto
Khan, Nazeer Hussain
Rauf, Saqib
Wang, Yi-Zhen
Qi, Hui-Wen
Wang, Di
Afzal, Attia
Ji, Xin-Ying
Wu, Dong-Dong
author_sort Khattak, Saadullah
collection PubMed
description Respiratory diseases are leading causes of death and disability around the globe, with a diverse range of health problems. Treatment of respiratory diseases and infections has been verified to be thought-provoking because of the increasing incidence and mortality rate. Hydrogen sulfide (H(2)S) is one of the recognized gaseous transmitters involved in an extensive range of cellular functions, and physiological and pathological processes in a variety of diseases, including respiratory diseases. Recently, the therapeutic potential of H(2)S for respiratory diseases has been widely investigated. H(2)S plays a vital therapeutic role in obstructive respiratory disease, pulmonary fibrosis, emphysema, pancreatic inflammatory/respiratory lung injury, pulmonary inflammation, bronchial asthma and bronchiectasis. Although the therapeutic role of H(2)S has been extensively studied in various respiratory diseases, a concrete literature review will have an extraordinary impact on future therapeutics. This review provides a comprehensive overview of the effective role of H(2)S in respiratory diseases. Besides, we also summarized H(2)S production in the lung and its metabolism processes in respiratory diseases.
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spelling pubmed-81473812021-05-26 The Role of Hydrogen Sulfide in Respiratory Diseases Khattak, Saadullah Zhang, Qian-Qian Sarfraz, Muhammad Muhammad, Pir Ngowi, Ebenezeri Erasto Khan, Nazeer Hussain Rauf, Saqib Wang, Yi-Zhen Qi, Hui-Wen Wang, Di Afzal, Attia Ji, Xin-Ying Wu, Dong-Dong Biomolecules Review Respiratory diseases are leading causes of death and disability around the globe, with a diverse range of health problems. Treatment of respiratory diseases and infections has been verified to be thought-provoking because of the increasing incidence and mortality rate. Hydrogen sulfide (H(2)S) is one of the recognized gaseous transmitters involved in an extensive range of cellular functions, and physiological and pathological processes in a variety of diseases, including respiratory diseases. Recently, the therapeutic potential of H(2)S for respiratory diseases has been widely investigated. H(2)S plays a vital therapeutic role in obstructive respiratory disease, pulmonary fibrosis, emphysema, pancreatic inflammatory/respiratory lung injury, pulmonary inflammation, bronchial asthma and bronchiectasis. Although the therapeutic role of H(2)S has been extensively studied in various respiratory diseases, a concrete literature review will have an extraordinary impact on future therapeutics. This review provides a comprehensive overview of the effective role of H(2)S in respiratory diseases. Besides, we also summarized H(2)S production in the lung and its metabolism processes in respiratory diseases. MDPI 2021-05-01 /pmc/articles/PMC8147381/ /pubmed/34062820 http://dx.doi.org/10.3390/biom11050682 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Khattak, Saadullah
Zhang, Qian-Qian
Sarfraz, Muhammad
Muhammad, Pir
Ngowi, Ebenezeri Erasto
Khan, Nazeer Hussain
Rauf, Saqib
Wang, Yi-Zhen
Qi, Hui-Wen
Wang, Di
Afzal, Attia
Ji, Xin-Ying
Wu, Dong-Dong
The Role of Hydrogen Sulfide in Respiratory Diseases
title The Role of Hydrogen Sulfide in Respiratory Diseases
title_full The Role of Hydrogen Sulfide in Respiratory Diseases
title_fullStr The Role of Hydrogen Sulfide in Respiratory Diseases
title_full_unstemmed The Role of Hydrogen Sulfide in Respiratory Diseases
title_short The Role of Hydrogen Sulfide in Respiratory Diseases
title_sort role of hydrogen sulfide in respiratory diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147381/
https://www.ncbi.nlm.nih.gov/pubmed/34062820
http://dx.doi.org/10.3390/biom11050682
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