Cargando…
Heterogeneity of Antibiotics Multidrug-Resistance Profile of Uropathogens in Romanian Population
Urinary tract infections (UTIs) are a leading cause of morbidity for both males and females. The overconsumption of antibiotics in general medicine, veterinary, or agriculture has led to a spike in drug-resistant microorganisms; obtaining standardized results is imposed by standard definitions for v...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147389/ https://www.ncbi.nlm.nih.gov/pubmed/34063317 http://dx.doi.org/10.3390/antibiotics10050523 |
_version_ | 1783697619843809280 |
---|---|
author | Petca, Răzvan-Cosmin Negoiță, Silvius Mareș, Cristian Petca, Aida Popescu, Răzvan-Ionuț Chibelean, Călin Bogdan |
author_facet | Petca, Răzvan-Cosmin Negoiță, Silvius Mareș, Cristian Petca, Aida Popescu, Răzvan-Ionuț Chibelean, Călin Bogdan |
author_sort | Petca, Răzvan-Cosmin |
collection | PubMed |
description | Urinary tract infections (UTIs) are a leading cause of morbidity for both males and females. The overconsumption of antibiotics in general medicine, veterinary, or agriculture has led to a spike in drug-resistant microorganisms; obtaining standardized results is imposed by standard definitions for various categories of drug-resistant bacteria—such as multiple-drug resistant (MDR), extensive drug-resistant (XDR), and pan drug-resistant (PDR). This retrospective study conducted in three university teaching hospitals in Romania has analyzed urine probes from 15,231 patients, of which 698 (4.58%) presented multidrug-resistant strains. Escherichia coli was the leading uropathogen 283 (40.54%), presenting the highest resistance to quinolones (R = 72.08%) and penicillin (R = 66.78%) with the most important patterns of resistance for penicillin, sulfonamides, and quinolones (12.01%) and aminoglycosides, aztreonam, cephalosporins, and quinolones (9.89%). Klebsiella spp. followed—260 (37.24%) with the highest resistance to amoxicillin-clavulanate (R = 94.61%) and cephalosporins (R = 94.23%); the leading patterns were observed for aminoglycosides, aminopenicillins + β-lactams inhibitor, sulfonamides, and cephalosporins (12.69%) and aminoglycosides, aztreonam, cephalosporins, quinolones (9.23%). The insufficient research of MDR strains on the Romanian population is promoting these findings as an important tool for any clinician treating MDR-UTIs. |
format | Online Article Text |
id | pubmed-8147389 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81473892021-05-26 Heterogeneity of Antibiotics Multidrug-Resistance Profile of Uropathogens in Romanian Population Petca, Răzvan-Cosmin Negoiță, Silvius Mareș, Cristian Petca, Aida Popescu, Răzvan-Ionuț Chibelean, Călin Bogdan Antibiotics (Basel) Article Urinary tract infections (UTIs) are a leading cause of morbidity for both males and females. The overconsumption of antibiotics in general medicine, veterinary, or agriculture has led to a spike in drug-resistant microorganisms; obtaining standardized results is imposed by standard definitions for various categories of drug-resistant bacteria—such as multiple-drug resistant (MDR), extensive drug-resistant (XDR), and pan drug-resistant (PDR). This retrospective study conducted in three university teaching hospitals in Romania has analyzed urine probes from 15,231 patients, of which 698 (4.58%) presented multidrug-resistant strains. Escherichia coli was the leading uropathogen 283 (40.54%), presenting the highest resistance to quinolones (R = 72.08%) and penicillin (R = 66.78%) with the most important patterns of resistance for penicillin, sulfonamides, and quinolones (12.01%) and aminoglycosides, aztreonam, cephalosporins, and quinolones (9.89%). Klebsiella spp. followed—260 (37.24%) with the highest resistance to amoxicillin-clavulanate (R = 94.61%) and cephalosporins (R = 94.23%); the leading patterns were observed for aminoglycosides, aminopenicillins + β-lactams inhibitor, sulfonamides, and cephalosporins (12.69%) and aminoglycosides, aztreonam, cephalosporins, quinolones (9.23%). The insufficient research of MDR strains on the Romanian population is promoting these findings as an important tool for any clinician treating MDR-UTIs. MDPI 2021-05-02 /pmc/articles/PMC8147389/ /pubmed/34063317 http://dx.doi.org/10.3390/antibiotics10050523 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Petca, Răzvan-Cosmin Negoiță, Silvius Mareș, Cristian Petca, Aida Popescu, Răzvan-Ionuț Chibelean, Călin Bogdan Heterogeneity of Antibiotics Multidrug-Resistance Profile of Uropathogens in Romanian Population |
title | Heterogeneity of Antibiotics Multidrug-Resistance Profile of Uropathogens in Romanian Population |
title_full | Heterogeneity of Antibiotics Multidrug-Resistance Profile of Uropathogens in Romanian Population |
title_fullStr | Heterogeneity of Antibiotics Multidrug-Resistance Profile of Uropathogens in Romanian Population |
title_full_unstemmed | Heterogeneity of Antibiotics Multidrug-Resistance Profile of Uropathogens in Romanian Population |
title_short | Heterogeneity of Antibiotics Multidrug-Resistance Profile of Uropathogens in Romanian Population |
title_sort | heterogeneity of antibiotics multidrug-resistance profile of uropathogens in romanian population |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147389/ https://www.ncbi.nlm.nih.gov/pubmed/34063317 http://dx.doi.org/10.3390/antibiotics10050523 |
work_keys_str_mv | AT petcarazvancosmin heterogeneityofantibioticsmultidrugresistanceprofileofuropathogensinromanianpopulation AT negoitasilvius heterogeneityofantibioticsmultidrugresistanceprofileofuropathogensinromanianpopulation AT marescristian heterogeneityofantibioticsmultidrugresistanceprofileofuropathogensinromanianpopulation AT petcaaida heterogeneityofantibioticsmultidrugresistanceprofileofuropathogensinromanianpopulation AT popescurazvanionut heterogeneityofantibioticsmultidrugresistanceprofileofuropathogensinromanianpopulation AT chibeleancalinbogdan heterogeneityofantibioticsmultidrugresistanceprofileofuropathogensinromanianpopulation |