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Heterogeneity of Antibiotics Multidrug-Resistance Profile of Uropathogens in Romanian Population

Urinary tract infections (UTIs) are a leading cause of morbidity for both males and females. The overconsumption of antibiotics in general medicine, veterinary, or agriculture has led to a spike in drug-resistant microorganisms; obtaining standardized results is imposed by standard definitions for v...

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Autores principales: Petca, Răzvan-Cosmin, Negoiță, Silvius, Mareș, Cristian, Petca, Aida, Popescu, Răzvan-Ionuț, Chibelean, Călin Bogdan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147389/
https://www.ncbi.nlm.nih.gov/pubmed/34063317
http://dx.doi.org/10.3390/antibiotics10050523
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author Petca, Răzvan-Cosmin
Negoiță, Silvius
Mareș, Cristian
Petca, Aida
Popescu, Răzvan-Ionuț
Chibelean, Călin Bogdan
author_facet Petca, Răzvan-Cosmin
Negoiță, Silvius
Mareș, Cristian
Petca, Aida
Popescu, Răzvan-Ionuț
Chibelean, Călin Bogdan
author_sort Petca, Răzvan-Cosmin
collection PubMed
description Urinary tract infections (UTIs) are a leading cause of morbidity for both males and females. The overconsumption of antibiotics in general medicine, veterinary, or agriculture has led to a spike in drug-resistant microorganisms; obtaining standardized results is imposed by standard definitions for various categories of drug-resistant bacteria—such as multiple-drug resistant (MDR), extensive drug-resistant (XDR), and pan drug-resistant (PDR). This retrospective study conducted in three university teaching hospitals in Romania has analyzed urine probes from 15,231 patients, of which 698 (4.58%) presented multidrug-resistant strains. Escherichia coli was the leading uropathogen 283 (40.54%), presenting the highest resistance to quinolones (R = 72.08%) and penicillin (R = 66.78%) with the most important patterns of resistance for penicillin, sulfonamides, and quinolones (12.01%) and aminoglycosides, aztreonam, cephalosporins, and quinolones (9.89%). Klebsiella spp. followed—260 (37.24%) with the highest resistance to amoxicillin-clavulanate (R = 94.61%) and cephalosporins (R = 94.23%); the leading patterns were observed for aminoglycosides, aminopenicillins + β-lactams inhibitor, sulfonamides, and cephalosporins (12.69%) and aminoglycosides, aztreonam, cephalosporins, quinolones (9.23%). The insufficient research of MDR strains on the Romanian population is promoting these findings as an important tool for any clinician treating MDR-UTIs.
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spelling pubmed-81473892021-05-26 Heterogeneity of Antibiotics Multidrug-Resistance Profile of Uropathogens in Romanian Population Petca, Răzvan-Cosmin Negoiță, Silvius Mareș, Cristian Petca, Aida Popescu, Răzvan-Ionuț Chibelean, Călin Bogdan Antibiotics (Basel) Article Urinary tract infections (UTIs) are a leading cause of morbidity for both males and females. The overconsumption of antibiotics in general medicine, veterinary, or agriculture has led to a spike in drug-resistant microorganisms; obtaining standardized results is imposed by standard definitions for various categories of drug-resistant bacteria—such as multiple-drug resistant (MDR), extensive drug-resistant (XDR), and pan drug-resistant (PDR). This retrospective study conducted in three university teaching hospitals in Romania has analyzed urine probes from 15,231 patients, of which 698 (4.58%) presented multidrug-resistant strains. Escherichia coli was the leading uropathogen 283 (40.54%), presenting the highest resistance to quinolones (R = 72.08%) and penicillin (R = 66.78%) with the most important patterns of resistance for penicillin, sulfonamides, and quinolones (12.01%) and aminoglycosides, aztreonam, cephalosporins, and quinolones (9.89%). Klebsiella spp. followed—260 (37.24%) with the highest resistance to amoxicillin-clavulanate (R = 94.61%) and cephalosporins (R = 94.23%); the leading patterns were observed for aminoglycosides, aminopenicillins + β-lactams inhibitor, sulfonamides, and cephalosporins (12.69%) and aminoglycosides, aztreonam, cephalosporins, quinolones (9.23%). The insufficient research of MDR strains on the Romanian population is promoting these findings as an important tool for any clinician treating MDR-UTIs. MDPI 2021-05-02 /pmc/articles/PMC8147389/ /pubmed/34063317 http://dx.doi.org/10.3390/antibiotics10050523 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Petca, Răzvan-Cosmin
Negoiță, Silvius
Mareș, Cristian
Petca, Aida
Popescu, Răzvan-Ionuț
Chibelean, Călin Bogdan
Heterogeneity of Antibiotics Multidrug-Resistance Profile of Uropathogens in Romanian Population
title Heterogeneity of Antibiotics Multidrug-Resistance Profile of Uropathogens in Romanian Population
title_full Heterogeneity of Antibiotics Multidrug-Resistance Profile of Uropathogens in Romanian Population
title_fullStr Heterogeneity of Antibiotics Multidrug-Resistance Profile of Uropathogens in Romanian Population
title_full_unstemmed Heterogeneity of Antibiotics Multidrug-Resistance Profile of Uropathogens in Romanian Population
title_short Heterogeneity of Antibiotics Multidrug-Resistance Profile of Uropathogens in Romanian Population
title_sort heterogeneity of antibiotics multidrug-resistance profile of uropathogens in romanian population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147389/
https://www.ncbi.nlm.nih.gov/pubmed/34063317
http://dx.doi.org/10.3390/antibiotics10050523
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