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Persistent Retinal Microvascular Impairment in COVID-19 Bilateral Pneumonia at 6-Months Follow-Up Assessed by Optical Coherence Tomography Angiography

The purpose of this study was to evaluate the long-term evolution of retinal changes in COVID-19 patients with bilateral pneumonia. A total of 17 COVID-19 patients underwent retinal imaging 6 months after hospital discharge with structural optical coherence tomography (OCT) and optical coherence tom...

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Autores principales: Bilbao-Malavé, Valentina, González-Zamora, Jorge, Saenz de Viteri, Manuel, de la Puente, Miriam, Gándara, Elsa, Casablanca-Piñera, Anna, Boquera-Ventosa, Claudia, Zarranz-Ventura, Javier, Landecho, Manuel F., García-Layana, Alfredo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147391/
https://www.ncbi.nlm.nih.gov/pubmed/34063291
http://dx.doi.org/10.3390/biomedicines9050502
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author Bilbao-Malavé, Valentina
González-Zamora, Jorge
Saenz de Viteri, Manuel
de la Puente, Miriam
Gándara, Elsa
Casablanca-Piñera, Anna
Boquera-Ventosa, Claudia
Zarranz-Ventura, Javier
Landecho, Manuel F.
García-Layana, Alfredo
author_facet Bilbao-Malavé, Valentina
González-Zamora, Jorge
Saenz de Viteri, Manuel
de la Puente, Miriam
Gándara, Elsa
Casablanca-Piñera, Anna
Boquera-Ventosa, Claudia
Zarranz-Ventura, Javier
Landecho, Manuel F.
García-Layana, Alfredo
author_sort Bilbao-Malavé, Valentina
collection PubMed
description The purpose of this study was to evaluate the long-term evolution of retinal changes in COVID-19 patients with bilateral pneumonia. A total of 17 COVID-19 patients underwent retinal imaging 6 months after hospital discharge with structural optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). The parafoveal retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) were significantly thinner in COVID-19 patients at 6 months compared to 0 months (p = <0.001 in both cases). In the optic nerve analysis, a significantly thinner RNFL was observed (p = 0.006) but persisted significantly thickened, compared to controls (p = 0.02). The vascular density (VD) at 6 months persisted significantly decreased when compared to the control group, and no significant differences were found with the 0 months evaluation; in addition, when analyzed separately, women showed a worsening in the VD. Moreover, a significantly greater foveal area zone (FAZ) (p = 0.003) was observed in COVID-19 patients at 6 months, compared to 0 months. The cotton wool spots (CWSs) observed at baseline were no longer present at 6 months, except for one patient that developed new ones. This study demonstrates that some of the previously known microvascular alterations resulting from COVID-19, persist over time and are still evident 6 months after hospital discharge in patients who have suffered from bilateral pneumonia.
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spelling pubmed-81473912021-05-26 Persistent Retinal Microvascular Impairment in COVID-19 Bilateral Pneumonia at 6-Months Follow-Up Assessed by Optical Coherence Tomography Angiography Bilbao-Malavé, Valentina González-Zamora, Jorge Saenz de Viteri, Manuel de la Puente, Miriam Gándara, Elsa Casablanca-Piñera, Anna Boquera-Ventosa, Claudia Zarranz-Ventura, Javier Landecho, Manuel F. García-Layana, Alfredo Biomedicines Article The purpose of this study was to evaluate the long-term evolution of retinal changes in COVID-19 patients with bilateral pneumonia. A total of 17 COVID-19 patients underwent retinal imaging 6 months after hospital discharge with structural optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). The parafoveal retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) were significantly thinner in COVID-19 patients at 6 months compared to 0 months (p = <0.001 in both cases). In the optic nerve analysis, a significantly thinner RNFL was observed (p = 0.006) but persisted significantly thickened, compared to controls (p = 0.02). The vascular density (VD) at 6 months persisted significantly decreased when compared to the control group, and no significant differences were found with the 0 months evaluation; in addition, when analyzed separately, women showed a worsening in the VD. Moreover, a significantly greater foveal area zone (FAZ) (p = 0.003) was observed in COVID-19 patients at 6 months, compared to 0 months. The cotton wool spots (CWSs) observed at baseline were no longer present at 6 months, except for one patient that developed new ones. This study demonstrates that some of the previously known microvascular alterations resulting from COVID-19, persist over time and are still evident 6 months after hospital discharge in patients who have suffered from bilateral pneumonia. MDPI 2021-05-02 /pmc/articles/PMC8147391/ /pubmed/34063291 http://dx.doi.org/10.3390/biomedicines9050502 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bilbao-Malavé, Valentina
González-Zamora, Jorge
Saenz de Viteri, Manuel
de la Puente, Miriam
Gándara, Elsa
Casablanca-Piñera, Anna
Boquera-Ventosa, Claudia
Zarranz-Ventura, Javier
Landecho, Manuel F.
García-Layana, Alfredo
Persistent Retinal Microvascular Impairment in COVID-19 Bilateral Pneumonia at 6-Months Follow-Up Assessed by Optical Coherence Tomography Angiography
title Persistent Retinal Microvascular Impairment in COVID-19 Bilateral Pneumonia at 6-Months Follow-Up Assessed by Optical Coherence Tomography Angiography
title_full Persistent Retinal Microvascular Impairment in COVID-19 Bilateral Pneumonia at 6-Months Follow-Up Assessed by Optical Coherence Tomography Angiography
title_fullStr Persistent Retinal Microvascular Impairment in COVID-19 Bilateral Pneumonia at 6-Months Follow-Up Assessed by Optical Coherence Tomography Angiography
title_full_unstemmed Persistent Retinal Microvascular Impairment in COVID-19 Bilateral Pneumonia at 6-Months Follow-Up Assessed by Optical Coherence Tomography Angiography
title_short Persistent Retinal Microvascular Impairment in COVID-19 Bilateral Pneumonia at 6-Months Follow-Up Assessed by Optical Coherence Tomography Angiography
title_sort persistent retinal microvascular impairment in covid-19 bilateral pneumonia at 6-months follow-up assessed by optical coherence tomography angiography
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147391/
https://www.ncbi.nlm.nih.gov/pubmed/34063291
http://dx.doi.org/10.3390/biomedicines9050502
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