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Daldiniaeschsone A, a Rare Tricyclic Polyketide Having a Chromone Unit Fused to a δ-Lactone and Its Symmetrical Biphenyl Dimer, Daldiniaeschsone B, from an Endophytic Fungus Daldinia eschscholtzii SDBR-CMUNKC745
Daldiniaeschsone A (1), a rare tricyclic polyketide having a chromone unit fused to a δ-lactone and its symmetrical 6,6′-biphenyl dimer, daldiniaeschsone B (2), together with three known compounds (3−5), were isolated from a plant-derived endophytic fungus, Daldinia eschscholtzii SDBR-CMUNKC745. The...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147462/ https://www.ncbi.nlm.nih.gov/pubmed/34063266 http://dx.doi.org/10.3390/jof7050358 |
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| author | Wutthiwong, Natnicha Suthiphasilp, Virayu Pintatum, Aknarin Suwannarach, Nakarin Kumla, Jaturong Lumyong, Saisamorn Maneerat, Tharakorn Charoensup, Rawiwan Cheenpracha, Sarot Limtharakul, Thunwadee Pyne, Stephen G. Laphookhieo, Surat |
| author_facet | Wutthiwong, Natnicha Suthiphasilp, Virayu Pintatum, Aknarin Suwannarach, Nakarin Kumla, Jaturong Lumyong, Saisamorn Maneerat, Tharakorn Charoensup, Rawiwan Cheenpracha, Sarot Limtharakul, Thunwadee Pyne, Stephen G. Laphookhieo, Surat |
| author_sort | Wutthiwong, Natnicha |
| collection | PubMed |
| description | Daldiniaeschsone A (1), a rare tricyclic polyketide having a chromone unit fused to a δ-lactone and its symmetrical 6,6′-biphenyl dimer, daldiniaeschsone B (2), together with three known compounds (3−5), were isolated from a plant-derived endophytic fungus, Daldinia eschscholtzii SDBR-CMUNKC745. Their structures were elucidated by extensive 1D and 2D NMR spectroscopic data and HRESIMS. All compounds showed α-glucosidase inhibitory activity with IC(50) values ranging from 0.16−0.85 mM and compound 1 was the best α-glucosidase inhibitory activity (IC(50) = 0.16 mM). |
| format | Online Article Text |
| id | pubmed-8147462 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-81474622021-05-26 Daldiniaeschsone A, a Rare Tricyclic Polyketide Having a Chromone Unit Fused to a δ-Lactone and Its Symmetrical Biphenyl Dimer, Daldiniaeschsone B, from an Endophytic Fungus Daldinia eschscholtzii SDBR-CMUNKC745 Wutthiwong, Natnicha Suthiphasilp, Virayu Pintatum, Aknarin Suwannarach, Nakarin Kumla, Jaturong Lumyong, Saisamorn Maneerat, Tharakorn Charoensup, Rawiwan Cheenpracha, Sarot Limtharakul, Thunwadee Pyne, Stephen G. Laphookhieo, Surat J Fungi (Basel) Article Daldiniaeschsone A (1), a rare tricyclic polyketide having a chromone unit fused to a δ-lactone and its symmetrical 6,6′-biphenyl dimer, daldiniaeschsone B (2), together with three known compounds (3−5), were isolated from a plant-derived endophytic fungus, Daldinia eschscholtzii SDBR-CMUNKC745. Their structures were elucidated by extensive 1D and 2D NMR spectroscopic data and HRESIMS. All compounds showed α-glucosidase inhibitory activity with IC(50) values ranging from 0.16−0.85 mM and compound 1 was the best α-glucosidase inhibitory activity (IC(50) = 0.16 mM). MDPI 2021-05-02 /pmc/articles/PMC8147462/ /pubmed/34063266 http://dx.doi.org/10.3390/jof7050358 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Wutthiwong, Natnicha Suthiphasilp, Virayu Pintatum, Aknarin Suwannarach, Nakarin Kumla, Jaturong Lumyong, Saisamorn Maneerat, Tharakorn Charoensup, Rawiwan Cheenpracha, Sarot Limtharakul, Thunwadee Pyne, Stephen G. Laphookhieo, Surat Daldiniaeschsone A, a Rare Tricyclic Polyketide Having a Chromone Unit Fused to a δ-Lactone and Its Symmetrical Biphenyl Dimer, Daldiniaeschsone B, from an Endophytic Fungus Daldinia eschscholtzii SDBR-CMUNKC745 |
| title | Daldiniaeschsone A, a Rare Tricyclic Polyketide Having a Chromone Unit Fused to a δ-Lactone and Its Symmetrical Biphenyl Dimer, Daldiniaeschsone B, from an Endophytic Fungus Daldinia eschscholtzii SDBR-CMUNKC745 |
| title_full | Daldiniaeschsone A, a Rare Tricyclic Polyketide Having a Chromone Unit Fused to a δ-Lactone and Its Symmetrical Biphenyl Dimer, Daldiniaeschsone B, from an Endophytic Fungus Daldinia eschscholtzii SDBR-CMUNKC745 |
| title_fullStr | Daldiniaeschsone A, a Rare Tricyclic Polyketide Having a Chromone Unit Fused to a δ-Lactone and Its Symmetrical Biphenyl Dimer, Daldiniaeschsone B, from an Endophytic Fungus Daldinia eschscholtzii SDBR-CMUNKC745 |
| title_full_unstemmed | Daldiniaeschsone A, a Rare Tricyclic Polyketide Having a Chromone Unit Fused to a δ-Lactone and Its Symmetrical Biphenyl Dimer, Daldiniaeschsone B, from an Endophytic Fungus Daldinia eschscholtzii SDBR-CMUNKC745 |
| title_short | Daldiniaeschsone A, a Rare Tricyclic Polyketide Having a Chromone Unit Fused to a δ-Lactone and Its Symmetrical Biphenyl Dimer, Daldiniaeschsone B, from an Endophytic Fungus Daldinia eschscholtzii SDBR-CMUNKC745 |
| title_sort | daldiniaeschsone a, a rare tricyclic polyketide having a chromone unit fused to a δ-lactone and its symmetrical biphenyl dimer, daldiniaeschsone b, from an endophytic fungus daldinia eschscholtzii sdbr-cmunkc745 |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147462/ https://www.ncbi.nlm.nih.gov/pubmed/34063266 http://dx.doi.org/10.3390/jof7050358 |
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