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Effect of Restriction of Fluoroquinolone Antibiotics on Clostridioides difficile Infections in the University Hospital Hradec Králové

Clostridioides difficile is the most common pathogen responsible for hospital-acquired diarrhea. This complication of antibiotic treatment mainly endangers the health of elder patients. Preventing the development of C. difficile infections (CDI) is still a challenge that needs to be addressed. In ou...

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Autores principales: Vaverková, Kristýna, Kracík, Martin, Ryšková, Lenka, Paterová, Pavla, Kukla, Rudolf, Hobzová, Lenka, Špánek, Roman, Žemličková, Helena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147471/
https://www.ncbi.nlm.nih.gov/pubmed/34063201
http://dx.doi.org/10.3390/antibiotics10050519
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author Vaverková, Kristýna
Kracík, Martin
Ryšková, Lenka
Paterová, Pavla
Kukla, Rudolf
Hobzová, Lenka
Špánek, Roman
Žemličková, Helena
author_facet Vaverková, Kristýna
Kracík, Martin
Ryšková, Lenka
Paterová, Pavla
Kukla, Rudolf
Hobzová, Lenka
Špánek, Roman
Žemličková, Helena
author_sort Vaverková, Kristýna
collection PubMed
description Clostridioides difficile is the most common pathogen responsible for hospital-acquired diarrhea. This complication of antibiotic treatment mainly endangers the health of elder patients. Preventing the development of C. difficile infections (CDI) is still a challenge that needs to be addressed. In our study, the results of 872 C. difficile positive stool samples were used to describe the epidemiological situation affected by a change in the prescription of fluoroquinolone antibiotics. In a total, 93 of strains were typed by polymerase chain reaction (PCR) and capillary gel electrophoresis. Between years 2014 and 2018 the decline in the fluoroquinolones consumption was 69.3 defined daily dose (DDD) per 1000 patient-days (from 103.3 to 34.0), in same period CDI incidence declined by 1.3 cases per 10,000 patient-bed days (from 5.6 to 4.3). Results of epidemiologic and statistical analysis shows that decline in fluoroquinolones consumption has significant influence on CDI incidence and prevalence of hypervirulent strains. In the University Hospital Hradec Králové properly managed antibiotic stewardship policy has reduced CDI incidence by 23.2% and lowered rate of hypervirulent ribotypes 001 and 176.
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spelling pubmed-81474712021-05-26 Effect of Restriction of Fluoroquinolone Antibiotics on Clostridioides difficile Infections in the University Hospital Hradec Králové Vaverková, Kristýna Kracík, Martin Ryšková, Lenka Paterová, Pavla Kukla, Rudolf Hobzová, Lenka Špánek, Roman Žemličková, Helena Antibiotics (Basel) Article Clostridioides difficile is the most common pathogen responsible for hospital-acquired diarrhea. This complication of antibiotic treatment mainly endangers the health of elder patients. Preventing the development of C. difficile infections (CDI) is still a challenge that needs to be addressed. In our study, the results of 872 C. difficile positive stool samples were used to describe the epidemiological situation affected by a change in the prescription of fluoroquinolone antibiotics. In a total, 93 of strains were typed by polymerase chain reaction (PCR) and capillary gel electrophoresis. Between years 2014 and 2018 the decline in the fluoroquinolones consumption was 69.3 defined daily dose (DDD) per 1000 patient-days (from 103.3 to 34.0), in same period CDI incidence declined by 1.3 cases per 10,000 patient-bed days (from 5.6 to 4.3). Results of epidemiologic and statistical analysis shows that decline in fluoroquinolones consumption has significant influence on CDI incidence and prevalence of hypervirulent strains. In the University Hospital Hradec Králové properly managed antibiotic stewardship policy has reduced CDI incidence by 23.2% and lowered rate of hypervirulent ribotypes 001 and 176. MDPI 2021-05-02 /pmc/articles/PMC8147471/ /pubmed/34063201 http://dx.doi.org/10.3390/antibiotics10050519 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vaverková, Kristýna
Kracík, Martin
Ryšková, Lenka
Paterová, Pavla
Kukla, Rudolf
Hobzová, Lenka
Špánek, Roman
Žemličková, Helena
Effect of Restriction of Fluoroquinolone Antibiotics on Clostridioides difficile Infections in the University Hospital Hradec Králové
title Effect of Restriction of Fluoroquinolone Antibiotics on Clostridioides difficile Infections in the University Hospital Hradec Králové
title_full Effect of Restriction of Fluoroquinolone Antibiotics on Clostridioides difficile Infections in the University Hospital Hradec Králové
title_fullStr Effect of Restriction of Fluoroquinolone Antibiotics on Clostridioides difficile Infections in the University Hospital Hradec Králové
title_full_unstemmed Effect of Restriction of Fluoroquinolone Antibiotics on Clostridioides difficile Infections in the University Hospital Hradec Králové
title_short Effect of Restriction of Fluoroquinolone Antibiotics on Clostridioides difficile Infections in the University Hospital Hradec Králové
title_sort effect of restriction of fluoroquinolone antibiotics on clostridioides difficile infections in the university hospital hradec králové
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147471/
https://www.ncbi.nlm.nih.gov/pubmed/34063201
http://dx.doi.org/10.3390/antibiotics10050519
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