The Evolution of Antisense Oligonucleotide Chemistry—A Personal Journey

Over the last four decades, tremendous progress has been made in use of synthetic oligonucleotides as therapeutics. This has been possible largely by introducing chemical modifications to provide drug like properties to oligonucleotides. In this article I have summarized twists and turns on use of c...

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Detalles Bibliográficos
Autor principal: Agrawal, Sudhir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147625/
https://www.ncbi.nlm.nih.gov/pubmed/34063675
http://dx.doi.org/10.3390/biomedicines9050503
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author Agrawal, Sudhir
author_facet Agrawal, Sudhir
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description Over the last four decades, tremendous progress has been made in use of synthetic oligonucleotides as therapeutics. This has been possible largely by introducing chemical modifications to provide drug like properties to oligonucleotides. In this article I have summarized twists and turns on use of chemical modifications and their road to success and highlight areas of future directions.
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spelling pubmed-81476252021-05-26 The Evolution of Antisense Oligonucleotide Chemistry—A Personal Journey Agrawal, Sudhir Biomedicines Review Over the last four decades, tremendous progress has been made in use of synthetic oligonucleotides as therapeutics. This has been possible largely by introducing chemical modifications to provide drug like properties to oligonucleotides. In this article I have summarized twists and turns on use of chemical modifications and their road to success and highlight areas of future directions. MDPI 2021-05-03 /pmc/articles/PMC8147625/ /pubmed/34063675 http://dx.doi.org/10.3390/biomedicines9050503 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Agrawal, Sudhir
The Evolution of Antisense Oligonucleotide Chemistry—A Personal Journey
title The Evolution of Antisense Oligonucleotide Chemistry—A Personal Journey
title_full The Evolution of Antisense Oligonucleotide Chemistry—A Personal Journey
title_fullStr The Evolution of Antisense Oligonucleotide Chemistry—A Personal Journey
title_full_unstemmed The Evolution of Antisense Oligonucleotide Chemistry—A Personal Journey
title_short The Evolution of Antisense Oligonucleotide Chemistry—A Personal Journey
title_sort evolution of antisense oligonucleotide chemistry—a personal journey
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147625/
https://www.ncbi.nlm.nih.gov/pubmed/34063675
http://dx.doi.org/10.3390/biomedicines9050503
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