Interaction between Omeprazole and Gliclazide in Relation to CYP2C19 Phenotype

The antidiabetic drug gliclazide is partly metabolized by CYP2C19, the main enzyme involved in omeprazole metabolism. The aim of the study was to explore the interaction between omeprazole and gliclazide in relation to CYP2C19 phenotype using physiologically based pharmacokinetic (PBPK) modeling app...

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Detalles Bibliográficos
Autores principales: Dujic, Tanja, Cvijic, Sandra, Elezovic, Amar, Bego, Tamer, Imamovic Kadric, Selma, Malenica, Maja, Elezovic, Alisa, Pearson, Ewan R., Kulo, Aida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147656/
https://www.ncbi.nlm.nih.gov/pubmed/34063566
http://dx.doi.org/10.3390/jpm11050367

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