Cargando…

Decoding Neuromuscular Disorders Using Phenotypic Clusters Obtained From Co-Occurrence Networks

Neuromuscular disorders (NMDs) represent an important subset of rare diseases associated with elevated morbidity and mortality whose diagnosis can take years. Here we present a novel approach using systems biology to produce functionally-coherent phenotype clusters that provide insight into the cell...

Descripción completa

Detalles Bibliográficos
Autores principales:	Díaz-Santiago, Elena, Claros, M. Gonzalo, Yahyaoui, Raquel, de Diego-Otero, Yolanda, Calvo, Rocío, Hoenicka, Janet, Palau, Francesc, Ranea, Juan A. G., Perkins, James R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147726/ https://www.ncbi.nlm.nih.gov/pubmed/34046427 http://dx.doi.org/10.3389/fmolb.2021.635074

Ejemplares similares

Decoding Partner Specificity of Opioid Receptor Family
por: Barreto, Carlos A. V., et al.
Publicado: (2021)

Dissecting the Extracellular Complexity of Neuromuscular Junction Organizers
por: Guarino, Salvatore R., et al.
Publicado: (2020)

Editorial: Recent breakthroughs in the decoding of circulating nucleic acids and their applications to human diseases
por: El-Daly, Sherien M., et al.
Publicado: (2023)

Decoding the Role of Epigenetics in Breast Cancer Using Formal Modeling and Machine-Learning Methods
por: Asim, Ayesha, et al.
Publicado: (2022)

Decoding the Structural Dynamics and Conformational Alternations of DNA Secondary Structures by Single-Molecule FRET Microspectroscopy
por: Bandyopadhyay, Debolina, et al.
Publicado: (2021)

Spinal Muscular Atrophy: From Defective Chaperoning of snRNP Assembly to Neuromuscular Dysfunction
por: Lanfranco, Maia, et al.
Publicado: (2017)

Decoding Cancer Variants of Unknown Significance for Helicase–Nuclease–RPA Complexes Orchestrating DNA Repair During Transcription and Replication
por: Tsutakawa, Susan E., et al.
Publicado: (2021)

Cancer Occurrence as the Upcoming Complications of COVID-19
por: Rahimmanesh, Ilnaz, et al.
Publicado: (2022)

The role of bile acid metabolism in the occurrence and development of NAFLD
por: Bing, Hao, et al.
Publicado: (2022)

Computational Investigation of Bending Properties of RNA AUUCU, CCUG, CAG, and CUG Repeat Expansions Associated With Neuromuscular Disorders
por: Taghavi, Amirhossein, et al.
Publicado: (2022)

Editorial: The Non-Coding Transcriptome as a New Player in Intercellular Communication
por: Devaux, Yvan, et al.
Publicado: (2022)

The Fate Status of Stem Cells in Diabetes and its Role in the Occurrence of Diabetic Complications
por: Xu, Jinyi, et al.
Publicado: (2021)

The chemistry of gut microbiome-derived lipopolysaccharides impacts on the occurrence of food allergy in the pediatric age
por: Di Lorenzo, Flaviana, et al.
Publicado: (2023)

An optimized approach and inflation media for obtaining complimentary mass spectrometry-based omics data from human lung tissue
por: Lukowski, Jessica K., et al.
Publicado: (2022)

Changes in Protonation States of In-Pathway Residues can Alter Ligand Binding Pathways Obtained From Spontaneous Binding Molecular Dynamics Simulations
por: Girame, Helena, et al.
Publicado: (2022)

Silencing of the tRNA Modification Enzyme Cdkal1 Effects Functional Insulin Synthesis in NIT-1 Cells: tRNA(Lys3) Lacking ms(2)- (ms(2)t(6)A(37)) is Unable to Establish Sufficient Anticodon:Codon Interactions to Decode the Wobble Codon AAG
por: Narendran, Amithi, et al.
Publicado: (2021)

The Increasing Impact of Translational Research in the Molecular Diagnostics of Neuromuscular Diseases
por: Yubero, Dèlia, et al.
Publicado: (2021)

Differential effects of Mendelian GDAP1 clinical variants on mitochondria-lysosome membrane contacts sites
por: Cantarero, Lara, et al.
Publicado: (2023)

Editorial: The Lesser Known World of RNA Polymerases
por: Calvo, Olga, et al.
Publicado: (2021)

Whole-Slide Image Analysis of Human Pancreas Samples to Elucidate the Immunopathogenesis of Type 1 Diabetes Using the QuPath Software
por: Apaolaza, Paola S., et al.
Publicado: (2021)

Family 1 glycosyltransferases (GT1, UGTs) are subject to dilution-induced inactivation and low chemo stability toward their own acceptor substrates
por: Teze, David, et al.
Publicado: (2022)

The Functional Role of Sphingosine Kinase 2
por: Diaz Escarcega, Rocio, et al.
Publicado: (2021)

Online breath analysis with SESI/HRMS for metabolic signatures in children with allergic asthma
por: Weber, Ronja, et al.
Publicado: (2023)

Regulation of Eukaryotic RNAPs Activities by Phosphorylation
por: González-Jiménez, Araceli, et al.
Publicado: (2021)

TurboPutative: A web server for data handling and metabolite classification in untargeted metabolomics
por: Barrero-Rodríguez, Rafael, et al.
Publicado: (2022)

Multi-omics analysis: Paving the path toward achieving precision medicine in cancer treatment and immuno-oncology
por: Raufaste-Cazavieille, Virgile, et al.
Publicado: (2022)

DEER Data Analysis Software: A Comparative Guide
por: Russell, Hannah, et al.
Publicado: (2022)

Quinate-based ligands for irreversible inactivation of the bacterial virulence factor DHQ1 enzyme—A molecular insight (†)
por: Rodríguez, Ángela, et al.
Publicado: (2023)

Biogenesis of RNA Polymerases in Yeast
por: Garrido-Godino, Ana I., et al.
Publicado: (2021)

Elevated VCAM-1, MCP-1 and ADMA serum levels related to pulmonary fibrosis of interstitial lung disease associated with rheumatoid arthritis
por: Pulito-Cueto, Verónica, et al.
Publicado: (2022)

Impact of Structural Observables From Simulations to Predict the Effect of Single-Point Mutations in MHC Class II Peptide Binders
por: Ochoa, Rodrigo, et al.
Publicado: (2021)

AlphaFold Models of Small Proteins Rival the Accuracy of Solution NMR Structures
por: Tejero, Roberto, et al.
Publicado: (2022)

A comparative NMR-based metabolomics study of lung parenchyma of severe COVID-19 patients
por: Hurtado, Joaquín I., et al.
Publicado: (2023)

ADAMTS-12: Functions and Challenges for a Complex Metalloprotease
por: Mohamedi, Yamina, et al.
Publicado: (2021)

Super-infection by multiple microorganisms in COVID-19 patients
por: Gomez, Andrea C., et al.
Publicado: (2023)

Impact of renal tubular Cpt1a overexpression on the kidney metabolome in the folic acid-induced fibrosis mouse model
por: Cuevas-Delgado, Paula, et al.
Publicado: (2023)

Structural and Functional Insights into Small, Glutamine-Rich, Tetratricopeptide Repeat Protein Alpha
por: Roberts, Joanna D., et al.
Publicado: (2015)

An experimental study of liquid micro-jets produced with a gas dynamic virtual nozzle under the influence of an electric field
por: Zupan, Bor, et al.
Publicado: (2023)

Quantitative plasma profiling by (1)H NMR-based metabolomics: impact of sample treatment
por: Madrid-Gambin, Francisco, et al.
Publicado: (2023)

Gaining Insights Into Metabolic Networks Using Chemometrics and Bioinformatics: Chronic Kidney Disease as a Clinical Model
por: Boccard, Julien, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3ba0m8b7ps4hkh188hmosj47kr