Survival and glycemic control in patients with co-existing squamous cell carcinoma and diabetes mellitus

AIM: This study examined the impact of diabetes mellitus (DM) on survival in squamous cell carcinoma (SCC) patients, and the impact of SCC on glycemic control. MATERIALS & METHODS: Patients with newly diagnosed SCC with and without DM were matched 1:1 (2007–2017). Overall survival and recurrence...

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Autores principales: Ederaine, Sophia A, Dominguez, Johanny Lopez, Harvey, Jamison A, Mangold, Aaron R, Cook, Curtiss B, Kosiorek, Heidi, Buras, Matthew, Coppola, Kyle, Karlin, Nina J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147738/
https://www.ncbi.nlm.nih.gov/pubmed/34046188
http://dx.doi.org/10.2144/fsoa-2020-0150
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author Ederaine, Sophia A
Dominguez, Johanny Lopez
Harvey, Jamison A
Mangold, Aaron R
Cook, Curtiss B
Kosiorek, Heidi
Buras, Matthew
Coppola, Kyle
Karlin, Nina J
author_facet Ederaine, Sophia A
Dominguez, Johanny Lopez
Harvey, Jamison A
Mangold, Aaron R
Cook, Curtiss B
Kosiorek, Heidi
Buras, Matthew
Coppola, Kyle
Karlin, Nina J
author_sort Ederaine, Sophia A
collection PubMed
description AIM: This study examined the impact of diabetes mellitus (DM) on survival in squamous cell carcinoma (SCC) patients, and the impact of SCC on glycemic control. MATERIALS & METHODS: Patients with newly diagnosed SCC with and without DM were matched 1:1 (2007–2017). Overall survival and recurrence-free survival were estimated using the Kaplan–Meier method. Hemoglobin A(1c) (HbA(1c)) and glucose level during the year following cancer diagnosis were compared using mixed models. RESULTS: HbA(1c) decreased over time in DM patients (p = 0.04). The 5-year overall survival was 61% in DM patients, compared with 78% in patients without DM (p = 0.004). CONCLUSION: The presence of co-existing DM adversely impacted survival in patients with SCC. SCC did not affect glycemic control.
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spelling pubmed-81477382021-05-26 Survival and glycemic control in patients with co-existing squamous cell carcinoma and diabetes mellitus Ederaine, Sophia A Dominguez, Johanny Lopez Harvey, Jamison A Mangold, Aaron R Cook, Curtiss B Kosiorek, Heidi Buras, Matthew Coppola, Kyle Karlin, Nina J Future Sci OA Research Article AIM: This study examined the impact of diabetes mellitus (DM) on survival in squamous cell carcinoma (SCC) patients, and the impact of SCC on glycemic control. MATERIALS & METHODS: Patients with newly diagnosed SCC with and without DM were matched 1:1 (2007–2017). Overall survival and recurrence-free survival were estimated using the Kaplan–Meier method. Hemoglobin A(1c) (HbA(1c)) and glucose level during the year following cancer diagnosis were compared using mixed models. RESULTS: HbA(1c) decreased over time in DM patients (p = 0.04). The 5-year overall survival was 61% in DM patients, compared with 78% in patients without DM (p = 0.004). CONCLUSION: The presence of co-existing DM adversely impacted survival in patients with SCC. SCC did not affect glycemic control. Future Science Ltd 2021-02-10 /pmc/articles/PMC8147738/ /pubmed/34046188 http://dx.doi.org/10.2144/fsoa-2020-0150 Text en © 2021 Mayo foundation for Medical Education and Research https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Research Article
Ederaine, Sophia A
Dominguez, Johanny Lopez
Harvey, Jamison A
Mangold, Aaron R
Cook, Curtiss B
Kosiorek, Heidi
Buras, Matthew
Coppola, Kyle
Karlin, Nina J
Survival and glycemic control in patients with co-existing squamous cell carcinoma and diabetes mellitus
title Survival and glycemic control in patients with co-existing squamous cell carcinoma and diabetes mellitus
title_full Survival and glycemic control in patients with co-existing squamous cell carcinoma and diabetes mellitus
title_fullStr Survival and glycemic control in patients with co-existing squamous cell carcinoma and diabetes mellitus
title_full_unstemmed Survival and glycemic control in patients with co-existing squamous cell carcinoma and diabetes mellitus
title_short Survival and glycemic control in patients with co-existing squamous cell carcinoma and diabetes mellitus
title_sort survival and glycemic control in patients with co-existing squamous cell carcinoma and diabetes mellitus
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147738/
https://www.ncbi.nlm.nih.gov/pubmed/34046188
http://dx.doi.org/10.2144/fsoa-2020-0150
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