Cargando…

Soluble urokinase-type plasminogen activator receptor strongly predicts global mortality in acute heart failure patients: insight from the STADE-HF registry

BACKGROUND: Whether soluble urokinase-type plasminogen activator receptor (suPAR) could be a valuable prognostic indicator remains uncertain. MATERIALS & METHODS: Patients from STADE-HF (Soluble Suppression of Tumorigenesis-2 as a Help for Management of Diagnosis, Evaluation and Management of He...

Descripción completa

Detalles Bibliográficos
Autores principales: Huet, Fabien, Dupuy, Anne-Marie, Duflos, Claire, Reis, Cintia Azara, Kuster, Nils, Aguilhon, Sylvain, Cristol, Jean-Paul, Roubille, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147742/
https://www.ncbi.nlm.nih.gov/pubmed/34046195
http://dx.doi.org/10.2144/fsoa-2020-0197
_version_ 1783697694033707008
author Huet, Fabien
Dupuy, Anne-Marie
Duflos, Claire
Reis, Cintia Azara
Kuster, Nils
Aguilhon, Sylvain
Cristol, Jean-Paul
Roubille, François
author_facet Huet, Fabien
Dupuy, Anne-Marie
Duflos, Claire
Reis, Cintia Azara
Kuster, Nils
Aguilhon, Sylvain
Cristol, Jean-Paul
Roubille, François
author_sort Huet, Fabien
collection PubMed
description BACKGROUND: Whether soluble urokinase-type plasminogen activator receptor (suPAR) could be a valuable prognostic indicator remains uncertain. MATERIALS & METHODS: Patients from STADE-HF (Soluble Suppression of Tumorigenesis-2 as a Help for Management of Diagnosis, Evaluation and Management of Heart Failure) were included for analysis. RESULTS: 95 patients were included. The suPAR level of expression was significantly higher in the group of patients who died at one month (7.90 ± 4.35 ng/ml vs 11.94 ± 6.86 ng/ml; p < 0.05) or 1 year (7.28 ± 4.27 ng/ml vs 11.81 ± 4.88 ng/ml; p < 0.01), but there was no significant difference according to the readmission. CONCLUSION: High suPAR levels during hospitalization for acute heart failure were highly predictive for the risk of mortality, but not the risk of readmission.
format Online
Article
Text
id pubmed-8147742
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Future Science Ltd
record_format MEDLINE/PubMed
spelling pubmed-81477422021-05-26 Soluble urokinase-type plasminogen activator receptor strongly predicts global mortality in acute heart failure patients: insight from the STADE-HF registry Huet, Fabien Dupuy, Anne-Marie Duflos, Claire Reis, Cintia Azara Kuster, Nils Aguilhon, Sylvain Cristol, Jean-Paul Roubille, François Future Sci OA Research Article BACKGROUND: Whether soluble urokinase-type plasminogen activator receptor (suPAR) could be a valuable prognostic indicator remains uncertain. MATERIALS & METHODS: Patients from STADE-HF (Soluble Suppression of Tumorigenesis-2 as a Help for Management of Diagnosis, Evaluation and Management of Heart Failure) were included for analysis. RESULTS: 95 patients were included. The suPAR level of expression was significantly higher in the group of patients who died at one month (7.90 ± 4.35 ng/ml vs 11.94 ± 6.86 ng/ml; p < 0.05) or 1 year (7.28 ± 4.27 ng/ml vs 11.81 ± 4.88 ng/ml; p < 0.01), but there was no significant difference according to the readmission. CONCLUSION: High suPAR levels during hospitalization for acute heart failure were highly predictive for the risk of mortality, but not the risk of readmission. Future Science Ltd 2021-03-29 /pmc/articles/PMC8147742/ /pubmed/34046195 http://dx.doi.org/10.2144/fsoa-2020-0197 Text en © 2021 Fabien Huet https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Research Article
Huet, Fabien
Dupuy, Anne-Marie
Duflos, Claire
Reis, Cintia Azara
Kuster, Nils
Aguilhon, Sylvain
Cristol, Jean-Paul
Roubille, François
Soluble urokinase-type plasminogen activator receptor strongly predicts global mortality in acute heart failure patients: insight from the STADE-HF registry
title Soluble urokinase-type plasminogen activator receptor strongly predicts global mortality in acute heart failure patients: insight from the STADE-HF registry
title_full Soluble urokinase-type plasminogen activator receptor strongly predicts global mortality in acute heart failure patients: insight from the STADE-HF registry
title_fullStr Soluble urokinase-type plasminogen activator receptor strongly predicts global mortality in acute heart failure patients: insight from the STADE-HF registry
title_full_unstemmed Soluble urokinase-type plasminogen activator receptor strongly predicts global mortality in acute heart failure patients: insight from the STADE-HF registry
title_short Soluble urokinase-type plasminogen activator receptor strongly predicts global mortality in acute heart failure patients: insight from the STADE-HF registry
title_sort soluble urokinase-type plasminogen activator receptor strongly predicts global mortality in acute heart failure patients: insight from the stade-hf registry
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147742/
https://www.ncbi.nlm.nih.gov/pubmed/34046195
http://dx.doi.org/10.2144/fsoa-2020-0197
work_keys_str_mv AT huetfabien solubleurokinasetypeplasminogenactivatorreceptorstronglypredictsglobalmortalityinacuteheartfailurepatientsinsightfromthestadehfregistry
AT dupuyannemarie solubleurokinasetypeplasminogenactivatorreceptorstronglypredictsglobalmortalityinacuteheartfailurepatientsinsightfromthestadehfregistry
AT duflosclaire solubleurokinasetypeplasminogenactivatorreceptorstronglypredictsglobalmortalityinacuteheartfailurepatientsinsightfromthestadehfregistry
AT reiscintiaazara solubleurokinasetypeplasminogenactivatorreceptorstronglypredictsglobalmortalityinacuteheartfailurepatientsinsightfromthestadehfregistry
AT kusternils solubleurokinasetypeplasminogenactivatorreceptorstronglypredictsglobalmortalityinacuteheartfailurepatientsinsightfromthestadehfregistry
AT aguilhonsylvain solubleurokinasetypeplasminogenactivatorreceptorstronglypredictsglobalmortalityinacuteheartfailurepatientsinsightfromthestadehfregistry
AT cristoljeanpaul solubleurokinasetypeplasminogenactivatorreceptorstronglypredictsglobalmortalityinacuteheartfailurepatientsinsightfromthestadehfregistry
AT roubillefrancois solubleurokinasetypeplasminogenactivatorreceptorstronglypredictsglobalmortalityinacuteheartfailurepatientsinsightfromthestadehfregistry