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Soluble urokinase-type plasminogen activator receptor strongly predicts global mortality in acute heart failure patients: insight from the STADE-HF registry
BACKGROUND: Whether soluble urokinase-type plasminogen activator receptor (suPAR) could be a valuable prognostic indicator remains uncertain. MATERIALS & METHODS: Patients from STADE-HF (Soluble Suppression of Tumorigenesis-2 as a Help for Management of Diagnosis, Evaluation and Management of He...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Future Science Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147742/ https://www.ncbi.nlm.nih.gov/pubmed/34046195 http://dx.doi.org/10.2144/fsoa-2020-0197 |
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author | Huet, Fabien Dupuy, Anne-Marie Duflos, Claire Reis, Cintia Azara Kuster, Nils Aguilhon, Sylvain Cristol, Jean-Paul Roubille, François |
author_facet | Huet, Fabien Dupuy, Anne-Marie Duflos, Claire Reis, Cintia Azara Kuster, Nils Aguilhon, Sylvain Cristol, Jean-Paul Roubille, François |
author_sort | Huet, Fabien |
collection | PubMed |
description | BACKGROUND: Whether soluble urokinase-type plasminogen activator receptor (suPAR) could be a valuable prognostic indicator remains uncertain. MATERIALS & METHODS: Patients from STADE-HF (Soluble Suppression of Tumorigenesis-2 as a Help for Management of Diagnosis, Evaluation and Management of Heart Failure) were included for analysis. RESULTS: 95 patients were included. The suPAR level of expression was significantly higher in the group of patients who died at one month (7.90 ± 4.35 ng/ml vs 11.94 ± 6.86 ng/ml; p < 0.05) or 1 year (7.28 ± 4.27 ng/ml vs 11.81 ± 4.88 ng/ml; p < 0.01), but there was no significant difference according to the readmission. CONCLUSION: High suPAR levels during hospitalization for acute heart failure were highly predictive for the risk of mortality, but not the risk of readmission. |
format | Online Article Text |
id | pubmed-8147742 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Future Science Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-81477422021-05-26 Soluble urokinase-type plasminogen activator receptor strongly predicts global mortality in acute heart failure patients: insight from the STADE-HF registry Huet, Fabien Dupuy, Anne-Marie Duflos, Claire Reis, Cintia Azara Kuster, Nils Aguilhon, Sylvain Cristol, Jean-Paul Roubille, François Future Sci OA Research Article BACKGROUND: Whether soluble urokinase-type plasminogen activator receptor (suPAR) could be a valuable prognostic indicator remains uncertain. MATERIALS & METHODS: Patients from STADE-HF (Soluble Suppression of Tumorigenesis-2 as a Help for Management of Diagnosis, Evaluation and Management of Heart Failure) were included for analysis. RESULTS: 95 patients were included. The suPAR level of expression was significantly higher in the group of patients who died at one month (7.90 ± 4.35 ng/ml vs 11.94 ± 6.86 ng/ml; p < 0.05) or 1 year (7.28 ± 4.27 ng/ml vs 11.81 ± 4.88 ng/ml; p < 0.01), but there was no significant difference according to the readmission. CONCLUSION: High suPAR levels during hospitalization for acute heart failure were highly predictive for the risk of mortality, but not the risk of readmission. Future Science Ltd 2021-03-29 /pmc/articles/PMC8147742/ /pubmed/34046195 http://dx.doi.org/10.2144/fsoa-2020-0197 Text en © 2021 Fabien Huet https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) |
spellingShingle | Research Article Huet, Fabien Dupuy, Anne-Marie Duflos, Claire Reis, Cintia Azara Kuster, Nils Aguilhon, Sylvain Cristol, Jean-Paul Roubille, François Soluble urokinase-type plasminogen activator receptor strongly predicts global mortality in acute heart failure patients: insight from the STADE-HF registry |
title | Soluble urokinase-type plasminogen activator receptor strongly predicts global mortality in acute heart failure patients: insight from the STADE-HF registry |
title_full | Soluble urokinase-type plasminogen activator receptor strongly predicts global mortality in acute heart failure patients: insight from the STADE-HF registry |
title_fullStr | Soluble urokinase-type plasminogen activator receptor strongly predicts global mortality in acute heart failure patients: insight from the STADE-HF registry |
title_full_unstemmed | Soluble urokinase-type plasminogen activator receptor strongly predicts global mortality in acute heart failure patients: insight from the STADE-HF registry |
title_short | Soluble urokinase-type plasminogen activator receptor strongly predicts global mortality in acute heart failure patients: insight from the STADE-HF registry |
title_sort | soluble urokinase-type plasminogen activator receptor strongly predicts global mortality in acute heart failure patients: insight from the stade-hf registry |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147742/ https://www.ncbi.nlm.nih.gov/pubmed/34046195 http://dx.doi.org/10.2144/fsoa-2020-0197 |
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