MicroRNAs miR-4535 and miR-1915-5p in amniotic fluid as predictive biomarkers for chorioamnionitis

BACKGROUND: This study was performed to investigate the clinical significance of miR-4535 and miR-1915-5p in severe chorioamnionitis. MATERIALS & METHODS: Amniotic fluid samples from 37 patients with severe chorioamnionitis were subjected to miRNA array analysis and ddPCR™. Diagnostic values wer...

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Detalles Bibliográficos
Autores principales: Kiyoshima, Chihiro, Shirasu, Naoto, Urushiyama, Daichi, Fukagawa, Satoshi, Hirakawa, Toyofumi, Yoshikawa, Kenichi, Izuchi, Daisuke, Miyata, Kohei, Kurakazu, Masamitsu, Yotsumoto, Fusanori, Hiromatsu, Kenji, Nomiyama, Makoto, Eiji, Ohta, Hirose, Shinichi, Ogura, Yoshitoshi, Hayashi, Tetsuya, Hata, Kenichiro, Nabeshima, Kazuki, Yasunaga, Shin'ichiro, Miyamoto, Shingo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147753/
https://www.ncbi.nlm.nih.gov/pubmed/34046191
http://dx.doi.org/10.2144/fsoa-2021-0006
Descripción
Sumario:BACKGROUND: This study was performed to investigate the clinical significance of miR-4535 and miR-1915-5p in severe chorioamnionitis. MATERIALS & METHODS: Amniotic fluid samples from 37 patients with severe chorioamnionitis were subjected to miRNA array analysis and ddPCR™. Diagnostic values were assessed using the receiver operating characteristic curve. The patients were separated into three groups according to Blanc’s criteria. RESULTS: The expression of miR-4535 and miR-1915-5p was significantly correlated with the copy number of 16S rDNA, had extremely high diagnostic accuracy for severe chorioamnionitis, and was linked to maternal and fetal inflammation. CONCLUSION: miR-4535 and miR-1915-5p serve as promising biomarkers for the diagnosis of severe chorioamnionitis.

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