Cargando…

AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review

5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr) has been one of the most commonly used pharmacological modulators of AMPK activity. The majority of early studies on the role of AMPK, both in the physiological regulation of metabolism and in cancer pathogenesis, were based solely on the use of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Višnjić, Dora, Lalić, Hrvoje, Dembitz, Vilma, Tomić, Barbara, Smoljo, Tomislav
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147799/ https://www.ncbi.nlm.nih.gov/pubmed/34064363 http://dx.doi.org/10.3390/cells10051095

Ejemplares similares

Bone marrow stromal cells reduce low-dose cytarabine-induced differentiation of acute myeloid leukemia
por: Smoljo, Tomislav, et al.
Publicado: (2023)

Cytarabine-induced differentiation of AML cells depends on Chk1 activation and shares the mechanism with inhibitors of DHODH and pyrimidine synthesis
por: Tomic, Barbara, et al.
Publicado: (2022)

The ribonucleoside AICAr induces differentiation of myeloid leukemia by activating the ATR/Chk1 via pyrimidine depletion
por: Dembitz, Vilma, et al.
Publicado: (2019)

5-Aminoimidazole-4-carboxamide ribonucleoside-induced autophagy flux during differentiation of monocytic leukemia cells
por: Dembitz, Vilma, et al.
Publicado: (2017)

5-aminoimidazole-4-carboxamide ribonucleoside induces differentiation in a subset of primary acute myeloid leukemia blasts
por: Dembitz, Vilma, et al.
Publicado: (2020)

Bendamustine: A review of pharmacology, clinical use and immunological effects
por: Lalic, Hrvoje, et al.
Publicado: (2022)

AMPK-dependent and independent effects of AICAR and compound C on T-cell responses
por: Rao, Enyu, et al.
Publicado: (2016)

AMPK-independent inhibition of human macrophage ER stress response by AICAR
por: Boß, Marcel, et al.
Publicado: (2016)

AMPK activation by AICAR sensitizes prostate cancer cells to radiotherapy
por: Rae, Colin, et al.
Publicado: (2019)

AICAR Antiproliferative Properties Involve the AMPK-Independent Activation of the Tumor Suppressors LATS 1 and 2
por: Philippe, Chloé, et al.
Publicado: (2018)

AICAR Prevents Heat Induced Sudden Death in RyR1 Mutant Mice Independent of AMPK Activation
por: Lanner, Johanna T., et al.
Publicado: (2012)

AMPK agonist AICAR improves cognition and motor coordination in young and aged mice
por: Kobilo, Tali, et al.
Publicado: (2014)

The AMPK Agonist AICAR Inhibits TGF-β1 Induced Activation of Kidney Myofibroblasts
por: Chen, Kuan-Hsing, et al.
Publicado: (2014)

AICAR-Induced Activation of AMPK Inhibits TSH/SREBP-2/HMGCR Pathway in Liver
por: Liu, Shudong, et al.
Publicado: (2015)

AMPK-induced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia
por: Leclerc, Gilles M, et al.
Publicado: (2010)

AICAR induces mitochondrial apoptosis in human osteosarcoma cells through an AMPK-dependent pathway
por: Morishita, Masayuki, et al.
Publicado: (2016)

Fanconi anemia protein FANCD2 is activated by AICAR, a modulator of AMPK and cellular energy metabolism
por: Chun, Min Jeong, et al.
Publicado: (2017)

AICAR inhibits NFκB DNA binding independently of AMPK to attenuate LPS-triggered inflammatory responses in human macrophages
por: Kirchner, Johannes, et al.
Publicado: (2018)

Use of Metformin Alone Is Not Associated with Survival Outcomes of Colorectal Cancer Cell but AMPK Activator AICAR Sensitizes Anticancer Effect of 5-Fluorouracil through AMPK Activation
por: Sui, Xinbing, et al.
Publicado: (2014)

The effect of an intracerebroventricular injection of metformin or AICAR on the plasma concentrations of melatonin in the ewe: potential involvement of AMPK?
por: Menassol, Jean-Baptiste, et al.
Publicado: (2011)

AMPK agonist AICAR ameliorates portal hypertension and liver cirrhosis via NO pathway in the BDL rat model
por: Hu, Liangshuo, et al.
Publicado: (2019)

The ULK1/2 and AMPK Inhibitor SBI-0206965 Blocks AICAR and Insulin-Stimulated Glucose Transport
por: Knudsen, Jonas R., et al.
Publicado: (2020)

Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle
por: Bultot, Laurent, et al.
Publicado: (2016)

AICAR-Induced AMPK Activation Inhibits the Noncanonical NF-κB Pathway to Attenuate Liver Injury and Fibrosis in BDL Rats
por: Zhu, Haoyang, et al.
Publicado: (2018)

The AMPK agonist 5‐aminoimidazole‐4‐carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation‐associated cachectic muscle wasting
por: Hall, Derek T, et al.
Publicado: (2018)

AICAR Induces Apoptosis and Inhibits Migration and Invasion in Prostate Cancer Cells Through an AMPK/mTOR-Dependent Pathway
por: Su, Chia-Cheng, et al.
Publicado: (2019)

AICAR and Metformin Exert AMPK-dependent Effects on INS-1E Pancreatic β-cell Apoptosis via Differential Downstream Mechanisms
por: Dai, Yu-Lu, et al.
Publicado: (2015)

Regulation of hepatic glucose production and AMPK by AICAR but not by metformin depends on drug uptake through the equilibrative nucleoside transporter 1 (ENT1)
por: Logie, Lisa, et al.
Publicado: (2018)

Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms
por: Chen, Suet Ching, et al.
Publicado: (2017)

AMP-independent activator of AMPK for treatment of mitochondrial disorders
por: Moore, Tereza, et al.
Publicado: (2020)

Adiponectin Facilitates Postconditioning Cardioprotection through Both AMPK-Dependent Nuclear and AMPK-Independent Mitochondrial STAT3 Activation
por: Zhu, Qiqi, et al.
Publicado: (2020)

Combined Treatment of MCF-7 Cells with AICAR and Methotrexate, Arrests Cell Cycle and Reverses Warburg Metabolism through AMP-Activated Protein Kinase (AMPK) and FOXO1
por: Fodor, Tamás, et al.
Publicado: (2016)

IQGAP1 binds AMPK and is required for maximum AMPK activation
por: Hedman, Andrew C., et al.
Publicado: (2020)

AMP-Activated Kinase (AMPK) Activation by AICAR in Human White Adipocytes Derived from Pericardial White Adipose Tissue Stem Cells Induces a Partial Beige-Like Phenotype
por: Abdul-Rahman, Omar, et al.
Publicado: (2016)

MLK3 Phophorylates AMPK Independently of LKB1
por: Luo, Lingyu, et al.
Publicado: (2015)

Synphilin-1 Interacts with AMPK and Increases AMPK Phosphorylation
por: Li, Tianxia, et al.
Publicado: (2020)

Hyperosmotic Stress Initiates AMPK-Independent Autophagy and AMPK- and Autophagy-Independent Depletion of Thioredoxin 1 and Glyoxalase 2 in HT22 Nerve Cells
por: Dafre, Alcir Luiz, et al.
Publicado: (2019)

Prior AICAR induces elevated glucose uptake concomitant with greater γ3-AMPK activation and reduced membrane cholesterol in skeletal muscle from 26-month-old rats
por: Wang, Haiyan, et al.
Publicado: (2022)

STIM2 interacts with AMPK and regulates calcium-induced AMPK activation
por: Chauhan, Anoop Singh, et al.
Publicado: (2019)

Fyn phosphorylates AMPK to inhibit AMPK activity and AMP-dependent activation of autophagy
por: Yamada, Eijiro, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_0fe2did5mft18un0r48mmaj9pe