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Role of Transportin-SR2 in HIV-1 Nuclear Import

The HIV replication cycle depends on the interaction of viral proteins with proteins of the host. Unraveling host–pathogen interactions during the infection is of great importance for understanding the pathogenesis and the development of antiviral therapies. To date HIV uncoating and nuclear import...

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Autores principales: Tabasi, Maryam, Nombela, Ivan, Janssens, Julie, Lahousse, Adrien P., Christ, Frauke, Debyser, Zeger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147801/
https://www.ncbi.nlm.nih.gov/pubmed/34064404
http://dx.doi.org/10.3390/v13050829
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author Tabasi, Maryam
Nombela, Ivan
Janssens, Julie
Lahousse, Adrien P.
Christ, Frauke
Debyser, Zeger
author_facet Tabasi, Maryam
Nombela, Ivan
Janssens, Julie
Lahousse, Adrien P.
Christ, Frauke
Debyser, Zeger
author_sort Tabasi, Maryam
collection PubMed
description The HIV replication cycle depends on the interaction of viral proteins with proteins of the host. Unraveling host–pathogen interactions during the infection is of great importance for understanding the pathogenesis and the development of antiviral therapies. To date HIV uncoating and nuclear import are the most debated steps of the HIV-1 replication cycle. Despite numerous studies during past decades, there is still much controversy with respect to the identity and the role of viral and host factors involved in these processes. In this review, we provide a comprehensive overview on the role of transportin-SR2 as a host cell factor during active nuclear transport.
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spelling pubmed-81478012021-05-26 Role of Transportin-SR2 in HIV-1 Nuclear Import Tabasi, Maryam Nombela, Ivan Janssens, Julie Lahousse, Adrien P. Christ, Frauke Debyser, Zeger Viruses Review The HIV replication cycle depends on the interaction of viral proteins with proteins of the host. Unraveling host–pathogen interactions during the infection is of great importance for understanding the pathogenesis and the development of antiviral therapies. To date HIV uncoating and nuclear import are the most debated steps of the HIV-1 replication cycle. Despite numerous studies during past decades, there is still much controversy with respect to the identity and the role of viral and host factors involved in these processes. In this review, we provide a comprehensive overview on the role of transportin-SR2 as a host cell factor during active nuclear transport. MDPI 2021-05-04 /pmc/articles/PMC8147801/ /pubmed/34064404 http://dx.doi.org/10.3390/v13050829 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tabasi, Maryam
Nombela, Ivan
Janssens, Julie
Lahousse, Adrien P.
Christ, Frauke
Debyser, Zeger
Role of Transportin-SR2 in HIV-1 Nuclear Import
title Role of Transportin-SR2 in HIV-1 Nuclear Import
title_full Role of Transportin-SR2 in HIV-1 Nuclear Import
title_fullStr Role of Transportin-SR2 in HIV-1 Nuclear Import
title_full_unstemmed Role of Transportin-SR2 in HIV-1 Nuclear Import
title_short Role of Transportin-SR2 in HIV-1 Nuclear Import
title_sort role of transportin-sr2 in hiv-1 nuclear import
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147801/
https://www.ncbi.nlm.nih.gov/pubmed/34064404
http://dx.doi.org/10.3390/v13050829
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