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Antimicrobial Susceptibility Patterns and Resistance Trends of Staphylococcus aureus and Coagulase-Negative Staphylococci Strains Isolated from Ocular Infections

Ocular bacterial infections represent a serious problem that affecting people of all age and genders. These infections can lead to visual impairment and blindness if not properly treated. The current study evaluates the antimicrobial resistance profiles and the resistance trend of both Staphylococcu...

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Autores principales: Petrillo, Francesco, Pignataro, Danilo, Di Lella, Federica Maria, Reibaldi, Michele, Fallico, Matteo, Castellino, Niccolò, Parisi, Guglielmo, Trotta, Maria Consiglia, D’Amico, Michele, Santella, Biagio, Folliero, Veronica, Della Rocca, Maria Teresa, Rinaldi, Michele, Franci, Gianluigi, Avitabile, Teresio, Galdiero, Marilena, Boccia, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147806/
https://www.ncbi.nlm.nih.gov/pubmed/34063711
http://dx.doi.org/10.3390/antibiotics10050527
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author Petrillo, Francesco
Pignataro, Danilo
Di Lella, Federica Maria
Reibaldi, Michele
Fallico, Matteo
Castellino, Niccolò
Parisi, Guglielmo
Trotta, Maria Consiglia
D’Amico, Michele
Santella, Biagio
Folliero, Veronica
Della Rocca, Maria Teresa
Rinaldi, Michele
Franci, Gianluigi
Avitabile, Teresio
Galdiero, Marilena
Boccia, Giovanni
author_facet Petrillo, Francesco
Pignataro, Danilo
Di Lella, Federica Maria
Reibaldi, Michele
Fallico, Matteo
Castellino, Niccolò
Parisi, Guglielmo
Trotta, Maria Consiglia
D’Amico, Michele
Santella, Biagio
Folliero, Veronica
Della Rocca, Maria Teresa
Rinaldi, Michele
Franci, Gianluigi
Avitabile, Teresio
Galdiero, Marilena
Boccia, Giovanni
author_sort Petrillo, Francesco
collection PubMed
description Ocular bacterial infections represent a serious problem that affecting people of all age and genders. These infections can lead to visual impairment and blindness if not properly treated. The current study evaluates the antimicrobial resistance profiles and the resistance trend of both Staphylococcus aureus (S. aureus) and coagulase-negative staphylococci (CoNS), the main pathogens involved in eye infections. A total of 322 isolates of S. aureus and CoNS, were collected from patients with bacterial conjunctivitis and keratitis at the “Luigi Vanvitelli” University Hospital of Campania in Naples, Italy, between 2017 and 2020. The isolated bacteria showed a high percentage of resistance to methicillin and other antibiotics commonly used for the treatment of ocular infections. Trends in antibiotic resistance were not encouraging, recording—especially among CoNS strains—an increase of more than 20% in resistance to methicillin and aminoglycosides during the study period. Instead, the resistance rates to tetracycline had a significant decrease in CoNS isolates while no changes in their susceptibility to fluoroquinolones and macrolides were observed. However, all isolates showed no resistance to trimethoprim/sulfamethoxazole and chloramphenicol. In this scenario, preventive identification of the infection causative agents and the evaluation of the antimicrobial susceptibility patterns are essential to set up an ocular infection effective drug treatment and also prevent antibiotic resistance.
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spelling pubmed-81478062021-05-26 Antimicrobial Susceptibility Patterns and Resistance Trends of Staphylococcus aureus and Coagulase-Negative Staphylococci Strains Isolated from Ocular Infections Petrillo, Francesco Pignataro, Danilo Di Lella, Federica Maria Reibaldi, Michele Fallico, Matteo Castellino, Niccolò Parisi, Guglielmo Trotta, Maria Consiglia D’Amico, Michele Santella, Biagio Folliero, Veronica Della Rocca, Maria Teresa Rinaldi, Michele Franci, Gianluigi Avitabile, Teresio Galdiero, Marilena Boccia, Giovanni Antibiotics (Basel) Article Ocular bacterial infections represent a serious problem that affecting people of all age and genders. These infections can lead to visual impairment and blindness if not properly treated. The current study evaluates the antimicrobial resistance profiles and the resistance trend of both Staphylococcus aureus (S. aureus) and coagulase-negative staphylococci (CoNS), the main pathogens involved in eye infections. A total of 322 isolates of S. aureus and CoNS, were collected from patients with bacterial conjunctivitis and keratitis at the “Luigi Vanvitelli” University Hospital of Campania in Naples, Italy, between 2017 and 2020. The isolated bacteria showed a high percentage of resistance to methicillin and other antibiotics commonly used for the treatment of ocular infections. Trends in antibiotic resistance were not encouraging, recording—especially among CoNS strains—an increase of more than 20% in resistance to methicillin and aminoglycosides during the study period. Instead, the resistance rates to tetracycline had a significant decrease in CoNS isolates while no changes in their susceptibility to fluoroquinolones and macrolides were observed. However, all isolates showed no resistance to trimethoprim/sulfamethoxazole and chloramphenicol. In this scenario, preventive identification of the infection causative agents and the evaluation of the antimicrobial susceptibility patterns are essential to set up an ocular infection effective drug treatment and also prevent antibiotic resistance. MDPI 2021-05-03 /pmc/articles/PMC8147806/ /pubmed/34063711 http://dx.doi.org/10.3390/antibiotics10050527 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Petrillo, Francesco
Pignataro, Danilo
Di Lella, Federica Maria
Reibaldi, Michele
Fallico, Matteo
Castellino, Niccolò
Parisi, Guglielmo
Trotta, Maria Consiglia
D’Amico, Michele
Santella, Biagio
Folliero, Veronica
Della Rocca, Maria Teresa
Rinaldi, Michele
Franci, Gianluigi
Avitabile, Teresio
Galdiero, Marilena
Boccia, Giovanni
Antimicrobial Susceptibility Patterns and Resistance Trends of Staphylococcus aureus and Coagulase-Negative Staphylococci Strains Isolated from Ocular Infections
title Antimicrobial Susceptibility Patterns and Resistance Trends of Staphylococcus aureus and Coagulase-Negative Staphylococci Strains Isolated from Ocular Infections
title_full Antimicrobial Susceptibility Patterns and Resistance Trends of Staphylococcus aureus and Coagulase-Negative Staphylococci Strains Isolated from Ocular Infections
title_fullStr Antimicrobial Susceptibility Patterns and Resistance Trends of Staphylococcus aureus and Coagulase-Negative Staphylococci Strains Isolated from Ocular Infections
title_full_unstemmed Antimicrobial Susceptibility Patterns and Resistance Trends of Staphylococcus aureus and Coagulase-Negative Staphylococci Strains Isolated from Ocular Infections
title_short Antimicrobial Susceptibility Patterns and Resistance Trends of Staphylococcus aureus and Coagulase-Negative Staphylococci Strains Isolated from Ocular Infections
title_sort antimicrobial susceptibility patterns and resistance trends of staphylococcus aureus and coagulase-negative staphylococci strains isolated from ocular infections
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147806/
https://www.ncbi.nlm.nih.gov/pubmed/34063711
http://dx.doi.org/10.3390/antibiotics10050527
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