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Antimicrobial Susceptibility Patterns and Resistance Trends of Staphylococcus aureus and Coagulase-Negative Staphylococci Strains Isolated from Ocular Infections
Ocular bacterial infections represent a serious problem that affecting people of all age and genders. These infections can lead to visual impairment and blindness if not properly treated. The current study evaluates the antimicrobial resistance profiles and the resistance trend of both Staphylococcu...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147806/ https://www.ncbi.nlm.nih.gov/pubmed/34063711 http://dx.doi.org/10.3390/antibiotics10050527 |
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author | Petrillo, Francesco Pignataro, Danilo Di Lella, Federica Maria Reibaldi, Michele Fallico, Matteo Castellino, Niccolò Parisi, Guglielmo Trotta, Maria Consiglia D’Amico, Michele Santella, Biagio Folliero, Veronica Della Rocca, Maria Teresa Rinaldi, Michele Franci, Gianluigi Avitabile, Teresio Galdiero, Marilena Boccia, Giovanni |
author_facet | Petrillo, Francesco Pignataro, Danilo Di Lella, Federica Maria Reibaldi, Michele Fallico, Matteo Castellino, Niccolò Parisi, Guglielmo Trotta, Maria Consiglia D’Amico, Michele Santella, Biagio Folliero, Veronica Della Rocca, Maria Teresa Rinaldi, Michele Franci, Gianluigi Avitabile, Teresio Galdiero, Marilena Boccia, Giovanni |
author_sort | Petrillo, Francesco |
collection | PubMed |
description | Ocular bacterial infections represent a serious problem that affecting people of all age and genders. These infections can lead to visual impairment and blindness if not properly treated. The current study evaluates the antimicrobial resistance profiles and the resistance trend of both Staphylococcus aureus (S. aureus) and coagulase-negative staphylococci (CoNS), the main pathogens involved in eye infections. A total of 322 isolates of S. aureus and CoNS, were collected from patients with bacterial conjunctivitis and keratitis at the “Luigi Vanvitelli” University Hospital of Campania in Naples, Italy, between 2017 and 2020. The isolated bacteria showed a high percentage of resistance to methicillin and other antibiotics commonly used for the treatment of ocular infections. Trends in antibiotic resistance were not encouraging, recording—especially among CoNS strains—an increase of more than 20% in resistance to methicillin and aminoglycosides during the study period. Instead, the resistance rates to tetracycline had a significant decrease in CoNS isolates while no changes in their susceptibility to fluoroquinolones and macrolides were observed. However, all isolates showed no resistance to trimethoprim/sulfamethoxazole and chloramphenicol. In this scenario, preventive identification of the infection causative agents and the evaluation of the antimicrobial susceptibility patterns are essential to set up an ocular infection effective drug treatment and also prevent antibiotic resistance. |
format | Online Article Text |
id | pubmed-8147806 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81478062021-05-26 Antimicrobial Susceptibility Patterns and Resistance Trends of Staphylococcus aureus and Coagulase-Negative Staphylococci Strains Isolated from Ocular Infections Petrillo, Francesco Pignataro, Danilo Di Lella, Federica Maria Reibaldi, Michele Fallico, Matteo Castellino, Niccolò Parisi, Guglielmo Trotta, Maria Consiglia D’Amico, Michele Santella, Biagio Folliero, Veronica Della Rocca, Maria Teresa Rinaldi, Michele Franci, Gianluigi Avitabile, Teresio Galdiero, Marilena Boccia, Giovanni Antibiotics (Basel) Article Ocular bacterial infections represent a serious problem that affecting people of all age and genders. These infections can lead to visual impairment and blindness if not properly treated. The current study evaluates the antimicrobial resistance profiles and the resistance trend of both Staphylococcus aureus (S. aureus) and coagulase-negative staphylococci (CoNS), the main pathogens involved in eye infections. A total of 322 isolates of S. aureus and CoNS, were collected from patients with bacterial conjunctivitis and keratitis at the “Luigi Vanvitelli” University Hospital of Campania in Naples, Italy, between 2017 and 2020. The isolated bacteria showed a high percentage of resistance to methicillin and other antibiotics commonly used for the treatment of ocular infections. Trends in antibiotic resistance were not encouraging, recording—especially among CoNS strains—an increase of more than 20% in resistance to methicillin and aminoglycosides during the study period. Instead, the resistance rates to tetracycline had a significant decrease in CoNS isolates while no changes in their susceptibility to fluoroquinolones and macrolides were observed. However, all isolates showed no resistance to trimethoprim/sulfamethoxazole and chloramphenicol. In this scenario, preventive identification of the infection causative agents and the evaluation of the antimicrobial susceptibility patterns are essential to set up an ocular infection effective drug treatment and also prevent antibiotic resistance. MDPI 2021-05-03 /pmc/articles/PMC8147806/ /pubmed/34063711 http://dx.doi.org/10.3390/antibiotics10050527 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Petrillo, Francesco Pignataro, Danilo Di Lella, Federica Maria Reibaldi, Michele Fallico, Matteo Castellino, Niccolò Parisi, Guglielmo Trotta, Maria Consiglia D’Amico, Michele Santella, Biagio Folliero, Veronica Della Rocca, Maria Teresa Rinaldi, Michele Franci, Gianluigi Avitabile, Teresio Galdiero, Marilena Boccia, Giovanni Antimicrobial Susceptibility Patterns and Resistance Trends of Staphylococcus aureus and Coagulase-Negative Staphylococci Strains Isolated from Ocular Infections |
title | Antimicrobial Susceptibility Patterns and Resistance Trends of Staphylococcus aureus and Coagulase-Negative Staphylococci Strains Isolated from Ocular Infections |
title_full | Antimicrobial Susceptibility Patterns and Resistance Trends of Staphylococcus aureus and Coagulase-Negative Staphylococci Strains Isolated from Ocular Infections |
title_fullStr | Antimicrobial Susceptibility Patterns and Resistance Trends of Staphylococcus aureus and Coagulase-Negative Staphylococci Strains Isolated from Ocular Infections |
title_full_unstemmed | Antimicrobial Susceptibility Patterns and Resistance Trends of Staphylococcus aureus and Coagulase-Negative Staphylococci Strains Isolated from Ocular Infections |
title_short | Antimicrobial Susceptibility Patterns and Resistance Trends of Staphylococcus aureus and Coagulase-Negative Staphylococci Strains Isolated from Ocular Infections |
title_sort | antimicrobial susceptibility patterns and resistance trends of staphylococcus aureus and coagulase-negative staphylococci strains isolated from ocular infections |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147806/ https://www.ncbi.nlm.nih.gov/pubmed/34063711 http://dx.doi.org/10.3390/antibiotics10050527 |
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