Cargando…
Psoriasis and Liver Damage in HIV-Infected Patients
Background/objectives: Psoriasis is the most frequent skin disease in HIV-infected patients. Nonalcohol fatty liver disease (NAFLD) is more prevalent in patients with psoriasis. We report the prevalence of psoriasis and NAFLD and investigate risk factors of liver damage in HIV-infected patients with...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147812/ https://www.ncbi.nlm.nih.gov/pubmed/34064387 http://dx.doi.org/10.3390/cells10051099 |
_version_ | 1783697710473281536 |
---|---|
author | Busca Arenzana, Carmen Quintana Castanedo, Lucía Chiloeches Fernández, Clara Nieto Rodríguez, Daniel Herranz Pinto, Pedro Delgado Hierro, Ana Belén Olveira Martín, Antonio Montes Ramírez, María Luisa |
author_facet | Busca Arenzana, Carmen Quintana Castanedo, Lucía Chiloeches Fernández, Clara Nieto Rodríguez, Daniel Herranz Pinto, Pedro Delgado Hierro, Ana Belén Olveira Martín, Antonio Montes Ramírez, María Luisa |
author_sort | Busca Arenzana, Carmen |
collection | PubMed |
description | Background/objectives: Psoriasis is the most frequent skin disease in HIV-infected patients. Nonalcohol fatty liver disease (NAFLD) is more prevalent in patients with psoriasis. We report the prevalence of psoriasis and NAFLD and investigate risk factors of liver damage in HIV-infected patients with psoriasis. Methods: We performed a retrospective observational study. Steatosis was defined as indicative abdominal ultrasound findings, CAP (controlled attenuated parameter by transient elastography) > 238 dB/m, and/or triglyceride and glucose index (TyG) > 8.38. Significant (fibrosis ≥ 2) and advanced liver fibrosis (fibrosis ≤ F3) were studied by transient elastography (TE) and/or FIB-4 using standard cutoff points. FIB-4 (Fibrosis 4 score) results were adjusted for hepatitis C (HCV)-coinfected patients. Results: We identified 80 patients with psoriasis (prevalence, 1.5%; 95% CI, 1.1–1.8). Psoriasis was severe (PASI > 10 and/or psoriatic arthritis) in 27.5% of cases. The prevalence of steatosis was 72.5% (95% CI, 65–85). Severe psoriasis was an independent risk factor for steatosis (OR, 12; 95% CI, 1.2–120; p = 0.03). Significant liver fibrosis (p < 0.05) was associated with HCV coinfection (OR 3.4; 95% CI, 1.1–10.6), total CD4 (OR 0.99; 95% CI, 0.99–1), and time of efavirenz exposure (OR 1.2; 95% CI, 1.0–1.3). Conclusions: The prevalence of psoriasis in HIV-infected patients was similar to that of the general population. Steatosis is highly prevalent, and severe psoriasis is an independent risk factor for steatosis in HIV-infected patients. |
format | Online Article Text |
id | pubmed-8147812 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81478122021-05-26 Psoriasis and Liver Damage in HIV-Infected Patients Busca Arenzana, Carmen Quintana Castanedo, Lucía Chiloeches Fernández, Clara Nieto Rodríguez, Daniel Herranz Pinto, Pedro Delgado Hierro, Ana Belén Olveira Martín, Antonio Montes Ramírez, María Luisa Cells Communication Background/objectives: Psoriasis is the most frequent skin disease in HIV-infected patients. Nonalcohol fatty liver disease (NAFLD) is more prevalent in patients with psoriasis. We report the prevalence of psoriasis and NAFLD and investigate risk factors of liver damage in HIV-infected patients with psoriasis. Methods: We performed a retrospective observational study. Steatosis was defined as indicative abdominal ultrasound findings, CAP (controlled attenuated parameter by transient elastography) > 238 dB/m, and/or triglyceride and glucose index (TyG) > 8.38. Significant (fibrosis ≥ 2) and advanced liver fibrosis (fibrosis ≤ F3) were studied by transient elastography (TE) and/or FIB-4 using standard cutoff points. FIB-4 (Fibrosis 4 score) results were adjusted for hepatitis C (HCV)-coinfected patients. Results: We identified 80 patients with psoriasis (prevalence, 1.5%; 95% CI, 1.1–1.8). Psoriasis was severe (PASI > 10 and/or psoriatic arthritis) in 27.5% of cases. The prevalence of steatosis was 72.5% (95% CI, 65–85). Severe psoriasis was an independent risk factor for steatosis (OR, 12; 95% CI, 1.2–120; p = 0.03). Significant liver fibrosis (p < 0.05) was associated with HCV coinfection (OR 3.4; 95% CI, 1.1–10.6), total CD4 (OR 0.99; 95% CI, 0.99–1), and time of efavirenz exposure (OR 1.2; 95% CI, 1.0–1.3). Conclusions: The prevalence of psoriasis in HIV-infected patients was similar to that of the general population. Steatosis is highly prevalent, and severe psoriasis is an independent risk factor for steatosis in HIV-infected patients. MDPI 2021-05-04 /pmc/articles/PMC8147812/ /pubmed/34064387 http://dx.doi.org/10.3390/cells10051099 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Busca Arenzana, Carmen Quintana Castanedo, Lucía Chiloeches Fernández, Clara Nieto Rodríguez, Daniel Herranz Pinto, Pedro Delgado Hierro, Ana Belén Olveira Martín, Antonio Montes Ramírez, María Luisa Psoriasis and Liver Damage in HIV-Infected Patients |
title | Psoriasis and Liver Damage in HIV-Infected Patients |
title_full | Psoriasis and Liver Damage in HIV-Infected Patients |
title_fullStr | Psoriasis and Liver Damage in HIV-Infected Patients |
title_full_unstemmed | Psoriasis and Liver Damage in HIV-Infected Patients |
title_short | Psoriasis and Liver Damage in HIV-Infected Patients |
title_sort | psoriasis and liver damage in hiv-infected patients |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147812/ https://www.ncbi.nlm.nih.gov/pubmed/34064387 http://dx.doi.org/10.3390/cells10051099 |
work_keys_str_mv | AT buscaarenzanacarmen psoriasisandliverdamageinhivinfectedpatients AT quintanacastanedolucia psoriasisandliverdamageinhivinfectedpatients AT chiloechesfernandezclara psoriasisandliverdamageinhivinfectedpatients AT nietorodriguezdaniel psoriasisandliverdamageinhivinfectedpatients AT herranzpintopedro psoriasisandliverdamageinhivinfectedpatients AT delgadohierroanabelen psoriasisandliverdamageinhivinfectedpatients AT olveiramartinantonio psoriasisandliverdamageinhivinfectedpatients AT montesramirezmarialuisa psoriasisandliverdamageinhivinfectedpatients |