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Molecular Insights into the Genetic Variability of ORF Virus in a Mediterranean Region (Sardinia, Italy)
Orf virus (ORFV) represents the causative agent of contagious ecthyma, clinically characterized by mild papular and pustular to severe proliferative lesions, mainly occurring in sheep and goats. In order to provide hints on the evolutionary history of this virus, we carried out a study aimed to asse...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147818/ https://www.ncbi.nlm.nih.gov/pubmed/34064326 http://dx.doi.org/10.3390/life11050416 |
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author | Coradduzza, Elisabetta Sanna, Daria Rocchigiani, Angela M. Pintus, Davide Scarpa, Fabio Scivoli, Rosario Bechere, Roberto Dettori, Maria A. Montesu, Maria A. Marras, Vincenzo Lobrano, Renato Ligios, Ciriaco Puggioni, Giantonella |
author_facet | Coradduzza, Elisabetta Sanna, Daria Rocchigiani, Angela M. Pintus, Davide Scarpa, Fabio Scivoli, Rosario Bechere, Roberto Dettori, Maria A. Montesu, Maria A. Marras, Vincenzo Lobrano, Renato Ligios, Ciriaco Puggioni, Giantonella |
author_sort | Coradduzza, Elisabetta |
collection | PubMed |
description | Orf virus (ORFV) represents the causative agent of contagious ecthyma, clinically characterized by mild papular and pustular to severe proliferative lesions, mainly occurring in sheep and goats. In order to provide hints on the evolutionary history of this virus, we carried out a study aimed to assess the genetic variation of ORFV in Sardinia that hosts a large affected small ruminant population. We also found a high worldwide mutational viral evolutionary rate, which resulted, in turn, higher than the rate we detected for the strains isolated in Sardinia. In addition, a well-supported genetic divergence was found between the viral strains isolated from sheep and those from goats, but no relevant connection was evidenced between the severity of lesions produced by ORFV and specific polymorphic patterns in the two species of hosts. Such a finding suggests that ORFV infection-related lesions are not necessarily linked to the expression of one of the three genes here analyzed and could rather be the effect of the expression of other genes or rather represents a multifactorial character. |
format | Online Article Text |
id | pubmed-8147818 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81478182021-05-26 Molecular Insights into the Genetic Variability of ORF Virus in a Mediterranean Region (Sardinia, Italy) Coradduzza, Elisabetta Sanna, Daria Rocchigiani, Angela M. Pintus, Davide Scarpa, Fabio Scivoli, Rosario Bechere, Roberto Dettori, Maria A. Montesu, Maria A. Marras, Vincenzo Lobrano, Renato Ligios, Ciriaco Puggioni, Giantonella Life (Basel) Article Orf virus (ORFV) represents the causative agent of contagious ecthyma, clinically characterized by mild papular and pustular to severe proliferative lesions, mainly occurring in sheep and goats. In order to provide hints on the evolutionary history of this virus, we carried out a study aimed to assess the genetic variation of ORFV in Sardinia that hosts a large affected small ruminant population. We also found a high worldwide mutational viral evolutionary rate, which resulted, in turn, higher than the rate we detected for the strains isolated in Sardinia. In addition, a well-supported genetic divergence was found between the viral strains isolated from sheep and those from goats, but no relevant connection was evidenced between the severity of lesions produced by ORFV and specific polymorphic patterns in the two species of hosts. Such a finding suggests that ORFV infection-related lesions are not necessarily linked to the expression of one of the three genes here analyzed and could rather be the effect of the expression of other genes or rather represents a multifactorial character. MDPI 2021-05-04 /pmc/articles/PMC8147818/ /pubmed/34064326 http://dx.doi.org/10.3390/life11050416 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Coradduzza, Elisabetta Sanna, Daria Rocchigiani, Angela M. Pintus, Davide Scarpa, Fabio Scivoli, Rosario Bechere, Roberto Dettori, Maria A. Montesu, Maria A. Marras, Vincenzo Lobrano, Renato Ligios, Ciriaco Puggioni, Giantonella Molecular Insights into the Genetic Variability of ORF Virus in a Mediterranean Region (Sardinia, Italy) |
title | Molecular Insights into the Genetic Variability of ORF Virus in a Mediterranean Region (Sardinia, Italy) |
title_full | Molecular Insights into the Genetic Variability of ORF Virus in a Mediterranean Region (Sardinia, Italy) |
title_fullStr | Molecular Insights into the Genetic Variability of ORF Virus in a Mediterranean Region (Sardinia, Italy) |
title_full_unstemmed | Molecular Insights into the Genetic Variability of ORF Virus in a Mediterranean Region (Sardinia, Italy) |
title_short | Molecular Insights into the Genetic Variability of ORF Virus in a Mediterranean Region (Sardinia, Italy) |
title_sort | molecular insights into the genetic variability of orf virus in a mediterranean region (sardinia, italy) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147818/ https://www.ncbi.nlm.nih.gov/pubmed/34064326 http://dx.doi.org/10.3390/life11050416 |
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