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Effect of LHCGR Gene Polymorphism (rs2293275) on LH Supplementation Protocol Outcomes in Second IVF Cycles: A Retrospective Study

Infertility is a major concern for couples wanting to have progeny. Despite recent advances in the field of IVF, success rates still need improvement. Understanding the patient’s variability and addressing it with personalized interventions may improve the success rate of fertilization and live birt...

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Autores principales: GA, Ramaraju, Cheemakurthi, Ravikrishna, Kalagara, Madan, Prathigudupu, Kavitha, Balabomma, Kavitha Lakshmi, Mahapatro, Pranati, Thota, Sivanarayana, Kommaraju, Aruna Lakshmi, Muvvala, Sanni Prasada Rao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147863/
https://www.ncbi.nlm.nih.gov/pubmed/34046009
http://dx.doi.org/10.3389/fendo.2021.628169
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author GA, Ramaraju
Cheemakurthi, Ravikrishna
Kalagara, Madan
Prathigudupu, Kavitha
Balabomma, Kavitha Lakshmi
Mahapatro, Pranati
Thota, Sivanarayana
Kommaraju, Aruna Lakshmi
Muvvala, Sanni Prasada Rao
author_facet GA, Ramaraju
Cheemakurthi, Ravikrishna
Kalagara, Madan
Prathigudupu, Kavitha
Balabomma, Kavitha Lakshmi
Mahapatro, Pranati
Thota, Sivanarayana
Kommaraju, Aruna Lakshmi
Muvvala, Sanni Prasada Rao
author_sort GA, Ramaraju
collection PubMed
description Infertility is a major concern for couples wanting to have progeny. Despite recent advances in the field of IVF, success rates still need improvement. Understanding the patient’s variability and addressing it with personalized interventions may improve the success rate of fertilization and live births. This study examined the impact of a personalized pharmacogenomic approach on LH supplementation on the pregnancy and live birth rate outcomes in comparison with the traditional approaches. 193 patients undergoing a second IVF cycle in Krishna IVF Clinic received LH supplementation either as per the conventional methods or based on N312S (rs2293275) LHCGR gene polymorphism. Results showed a significant increase in pregnancy rate (P-value: 0.049) and a trend showing improvement in live birth rates (P-value: 0.082) when r-hLH supplementation protocol was decided as per the genotypes A/A, A/G, and G/G of the N312S variant in the respective patients. This stimulation regimen helped in providing optimum levels of r-hLH supplementation to patients with impaired hormone-receptor interacting activity, to achieve higher success in pregnancy and live birth rates.
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spelling pubmed-81478632021-05-26 Effect of LHCGR Gene Polymorphism (rs2293275) on LH Supplementation Protocol Outcomes in Second IVF Cycles: A Retrospective Study GA, Ramaraju Cheemakurthi, Ravikrishna Kalagara, Madan Prathigudupu, Kavitha Balabomma, Kavitha Lakshmi Mahapatro, Pranati Thota, Sivanarayana Kommaraju, Aruna Lakshmi Muvvala, Sanni Prasada Rao Front Endocrinol (Lausanne) Endocrinology Infertility is a major concern for couples wanting to have progeny. Despite recent advances in the field of IVF, success rates still need improvement. Understanding the patient’s variability and addressing it with personalized interventions may improve the success rate of fertilization and live births. This study examined the impact of a personalized pharmacogenomic approach on LH supplementation on the pregnancy and live birth rate outcomes in comparison with the traditional approaches. 193 patients undergoing a second IVF cycle in Krishna IVF Clinic received LH supplementation either as per the conventional methods or based on N312S (rs2293275) LHCGR gene polymorphism. Results showed a significant increase in pregnancy rate (P-value: 0.049) and a trend showing improvement in live birth rates (P-value: 0.082) when r-hLH supplementation protocol was decided as per the genotypes A/A, A/G, and G/G of the N312S variant in the respective patients. This stimulation regimen helped in providing optimum levels of r-hLH supplementation to patients with impaired hormone-receptor interacting activity, to achieve higher success in pregnancy and live birth rates. Frontiers Media S.A. 2021-05-11 /pmc/articles/PMC8147863/ /pubmed/34046009 http://dx.doi.org/10.3389/fendo.2021.628169 Text en Copyright © 2021 GA, Cheemakurthi, Kalagara, Prathigudupu, Balabomma, Mahapatro, Thota, Kommaraju and Muvvala https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
GA, Ramaraju
Cheemakurthi, Ravikrishna
Kalagara, Madan
Prathigudupu, Kavitha
Balabomma, Kavitha Lakshmi
Mahapatro, Pranati
Thota, Sivanarayana
Kommaraju, Aruna Lakshmi
Muvvala, Sanni Prasada Rao
Effect of LHCGR Gene Polymorphism (rs2293275) on LH Supplementation Protocol Outcomes in Second IVF Cycles: A Retrospective Study
title Effect of LHCGR Gene Polymorphism (rs2293275) on LH Supplementation Protocol Outcomes in Second IVF Cycles: A Retrospective Study
title_full Effect of LHCGR Gene Polymorphism (rs2293275) on LH Supplementation Protocol Outcomes in Second IVF Cycles: A Retrospective Study
title_fullStr Effect of LHCGR Gene Polymorphism (rs2293275) on LH Supplementation Protocol Outcomes in Second IVF Cycles: A Retrospective Study
title_full_unstemmed Effect of LHCGR Gene Polymorphism (rs2293275) on LH Supplementation Protocol Outcomes in Second IVF Cycles: A Retrospective Study
title_short Effect of LHCGR Gene Polymorphism (rs2293275) on LH Supplementation Protocol Outcomes in Second IVF Cycles: A Retrospective Study
title_sort effect of lhcgr gene polymorphism (rs2293275) on lh supplementation protocol outcomes in second ivf cycles: a retrospective study
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147863/
https://www.ncbi.nlm.nih.gov/pubmed/34046009
http://dx.doi.org/10.3389/fendo.2021.628169
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