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A Rare Case of Tularemia Complicated by Rhabdomyolysis with a Successful Outcome

We present a case of tularemia complicated by rhabdomyolysis in a 43-year-old male who presented with fever, swelling, and pain of the right groin and a history of a week-old tick bite. Empirical parenteral amoxicillin/clavulanic acid treatment was initiated. Suspecting tularemia, parenteral gentamy...

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Autores principales: Kubiliute, Ieva, Zablockiene, Birute, Paulauskiene, Rasute, Navickas, Giedrius, Jancoriene, Ligita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147915/
https://www.ncbi.nlm.nih.gov/pubmed/34062973
http://dx.doi.org/10.3390/medicina57050449
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author Kubiliute, Ieva
Zablockiene, Birute
Paulauskiene, Rasute
Navickas, Giedrius
Jancoriene, Ligita
author_facet Kubiliute, Ieva
Zablockiene, Birute
Paulauskiene, Rasute
Navickas, Giedrius
Jancoriene, Ligita
author_sort Kubiliute, Ieva
collection PubMed
description We present a case of tularemia complicated by rhabdomyolysis in a 43-year-old male who presented with fever, swelling, and pain of the right groin and a history of a week-old tick bite. Empirical parenteral amoxicillin/clavulanic acid treatment was initiated. Suspecting tularemia, parenteral gentamycin was added. Later, the patient started to complain of muscle pain, weakness, and difficulties in breathing and walking. Heightened levels of creatine kinase and myoglobin concentration (42,670 IU/L and >12,000 μg/L, respectively) were found. Due to rhabdomyolysis, large amounts of intravenous fluid therapy were initiated to prevent kidney damage, continuing intravenous antibiotic therapy. Francisella tularensis IgG in serum was found to be positive only on the sixteenth day of hospitalization. Upon discharge, the laboratory analyses returned to normal levels, and the patient was in good condition. The successful outcome could be associated with the early appropriate therapy of tularemia and its rare complication of rhabdomyolysis.
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spelling pubmed-81479152021-05-26 A Rare Case of Tularemia Complicated by Rhabdomyolysis with a Successful Outcome Kubiliute, Ieva Zablockiene, Birute Paulauskiene, Rasute Navickas, Giedrius Jancoriene, Ligita Medicina (Kaunas) Case Report We present a case of tularemia complicated by rhabdomyolysis in a 43-year-old male who presented with fever, swelling, and pain of the right groin and a history of a week-old tick bite. Empirical parenteral amoxicillin/clavulanic acid treatment was initiated. Suspecting tularemia, parenteral gentamycin was added. Later, the patient started to complain of muscle pain, weakness, and difficulties in breathing and walking. Heightened levels of creatine kinase and myoglobin concentration (42,670 IU/L and >12,000 μg/L, respectively) were found. Due to rhabdomyolysis, large amounts of intravenous fluid therapy were initiated to prevent kidney damage, continuing intravenous antibiotic therapy. Francisella tularensis IgG in serum was found to be positive only on the sixteenth day of hospitalization. Upon discharge, the laboratory analyses returned to normal levels, and the patient was in good condition. The successful outcome could be associated with the early appropriate therapy of tularemia and its rare complication of rhabdomyolysis. MDPI 2021-05-05 /pmc/articles/PMC8147915/ /pubmed/34062973 http://dx.doi.org/10.3390/medicina57050449 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Kubiliute, Ieva
Zablockiene, Birute
Paulauskiene, Rasute
Navickas, Giedrius
Jancoriene, Ligita
A Rare Case of Tularemia Complicated by Rhabdomyolysis with a Successful Outcome
title A Rare Case of Tularemia Complicated by Rhabdomyolysis with a Successful Outcome
title_full A Rare Case of Tularemia Complicated by Rhabdomyolysis with a Successful Outcome
title_fullStr A Rare Case of Tularemia Complicated by Rhabdomyolysis with a Successful Outcome
title_full_unstemmed A Rare Case of Tularemia Complicated by Rhabdomyolysis with a Successful Outcome
title_short A Rare Case of Tularemia Complicated by Rhabdomyolysis with a Successful Outcome
title_sort rare case of tularemia complicated by rhabdomyolysis with a successful outcome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147915/
https://www.ncbi.nlm.nih.gov/pubmed/34062973
http://dx.doi.org/10.3390/medicina57050449
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