Cargando…

Debulking Surgery Combined with Low-Dose Oral Prednisolone and Azathioprine for Intractable IgG4-Related Orbital Disease: A Case Report

A case of intractable IgG4-related orbital disease (IgG4-ROD) was successfully treated by debulking surgery combined with low-dose prednisolone and azathioprine as maintenance therapy. A 64-year-old man visited our clinic with progressive bilateral upper eyelid swelling and right eye fullness of a y...

Descripción completa

Detalles Bibliográficos
Autores principales: Kuo, Hua-Hsuan, Chen, Chen-Hung, Wu, Shu-Ya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147960/
https://www.ncbi.nlm.nih.gov/pubmed/34064500
http://dx.doi.org/10.3390/medicina57050448
_version_ 1783697745217847296
author Kuo, Hua-Hsuan
Chen, Chen-Hung
Wu, Shu-Ya
author_facet Kuo, Hua-Hsuan
Chen, Chen-Hung
Wu, Shu-Ya
author_sort Kuo, Hua-Hsuan
collection PubMed
description A case of intractable IgG4-related orbital disease (IgG4-ROD) was successfully treated by debulking surgery combined with low-dose prednisolone and azathioprine as maintenance therapy. A 64-year-old man visited our clinic with progressive bilateral upper eyelid swelling and right eye fullness of a year’s duration. He was previously treated with systemic corticosteroids for the IgG4-ROD and experienced a partial clinical response but relapsed upon prednisolone cessation. The patient underwent debulking surgery of the right lacrimal gland and right upper eyelid. His post-operative medication was oral prednisolone (5 mg) every other day and 50 mg azathioprine per day. The patient’s right eye remained asymptomatic during the 18 months of follow-up. Debulking surgery combined with low-dose prednisolone and azathioprine, as a maintenance therapy, is an effective and alternative treatment for the long-term control of intractable IgG4-ROD.
format Online
Article
Text
id pubmed-8147960
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-81479602021-05-26 Debulking Surgery Combined with Low-Dose Oral Prednisolone and Azathioprine for Intractable IgG4-Related Orbital Disease: A Case Report Kuo, Hua-Hsuan Chen, Chen-Hung Wu, Shu-Ya Medicina (Kaunas) Case Report A case of intractable IgG4-related orbital disease (IgG4-ROD) was successfully treated by debulking surgery combined with low-dose prednisolone and azathioprine as maintenance therapy. A 64-year-old man visited our clinic with progressive bilateral upper eyelid swelling and right eye fullness of a year’s duration. He was previously treated with systemic corticosteroids for the IgG4-ROD and experienced a partial clinical response but relapsed upon prednisolone cessation. The patient underwent debulking surgery of the right lacrimal gland and right upper eyelid. His post-operative medication was oral prednisolone (5 mg) every other day and 50 mg azathioprine per day. The patient’s right eye remained asymptomatic during the 18 months of follow-up. Debulking surgery combined with low-dose prednisolone and azathioprine, as a maintenance therapy, is an effective and alternative treatment for the long-term control of intractable IgG4-ROD. MDPI 2021-05-04 /pmc/articles/PMC8147960/ /pubmed/34064500 http://dx.doi.org/10.3390/medicina57050448 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Kuo, Hua-Hsuan
Chen, Chen-Hung
Wu, Shu-Ya
Debulking Surgery Combined with Low-Dose Oral Prednisolone and Azathioprine for Intractable IgG4-Related Orbital Disease: A Case Report
title Debulking Surgery Combined with Low-Dose Oral Prednisolone and Azathioprine for Intractable IgG4-Related Orbital Disease: A Case Report
title_full Debulking Surgery Combined with Low-Dose Oral Prednisolone and Azathioprine for Intractable IgG4-Related Orbital Disease: A Case Report
title_fullStr Debulking Surgery Combined with Low-Dose Oral Prednisolone and Azathioprine for Intractable IgG4-Related Orbital Disease: A Case Report
title_full_unstemmed Debulking Surgery Combined with Low-Dose Oral Prednisolone and Azathioprine for Intractable IgG4-Related Orbital Disease: A Case Report
title_short Debulking Surgery Combined with Low-Dose Oral Prednisolone and Azathioprine for Intractable IgG4-Related Orbital Disease: A Case Report
title_sort debulking surgery combined with low-dose oral prednisolone and azathioprine for intractable igg4-related orbital disease: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147960/
https://www.ncbi.nlm.nih.gov/pubmed/34064500
http://dx.doi.org/10.3390/medicina57050448
work_keys_str_mv AT kuohuahsuan debulkingsurgerycombinedwithlowdoseoralprednisoloneandazathioprineforintractableigg4relatedorbitaldiseaseacasereport
AT chenchenhung debulkingsurgerycombinedwithlowdoseoralprednisoloneandazathioprineforintractableigg4relatedorbitaldiseaseacasereport
AT wushuya debulkingsurgerycombinedwithlowdoseoralprednisoloneandazathioprineforintractableigg4relatedorbitaldiseaseacasereport