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Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids
Flavonoids are among the most abundant natural bioactive compounds produced by plants. Many different activities have been reported for these secondary metabolites against numerous cells and systems. One of the most interesting is certainly the antimicrobial, which is stimulated through various mole...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147964/ https://www.ncbi.nlm.nih.gov/pubmed/34062983 http://dx.doi.org/10.3390/pharmaceutics13050660 |
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author | Donadio, Giuliana Mensitieri, Francesca Santoro, Valentina Parisi, Valentina Bellone, Maria Laura De Tommasi, Nunziatina Izzo, Viviana Dal Piaz, Fabrizio |
author_facet | Donadio, Giuliana Mensitieri, Francesca Santoro, Valentina Parisi, Valentina Bellone, Maria Laura De Tommasi, Nunziatina Izzo, Viviana Dal Piaz, Fabrizio |
author_sort | Donadio, Giuliana |
collection | PubMed |
description | Flavonoids are among the most abundant natural bioactive compounds produced by plants. Many different activities have been reported for these secondary metabolites against numerous cells and systems. One of the most interesting is certainly the antimicrobial, which is stimulated through various molecular mechanisms. In fact, flavonoids are effective both in directly damaging the envelope of Gram-negative and Gram-positive bacteria but also by acting toward specific molecular targets essential for the survival of these microorganisms. The purpose of this paper is to present an overview of the most interesting results obtained in the research focused on the study of the interactions between flavonoids and bacterial proteins. Despite the great structural heterogeneity of these plant metabolites, it is interesting to observe that many flavonoids affect the same cellular pathways. Furthermore, it is evident that some of these compounds interact with more than one target, producing multiple effects. Taken together, the reported data demonstrate the great potential of flavonoids in developing innovative systems, which can help address the increasingly serious problem of antibiotic resistance. |
format | Online Article Text |
id | pubmed-8147964 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81479642021-05-26 Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids Donadio, Giuliana Mensitieri, Francesca Santoro, Valentina Parisi, Valentina Bellone, Maria Laura De Tommasi, Nunziatina Izzo, Viviana Dal Piaz, Fabrizio Pharmaceutics Review Flavonoids are among the most abundant natural bioactive compounds produced by plants. Many different activities have been reported for these secondary metabolites against numerous cells and systems. One of the most interesting is certainly the antimicrobial, which is stimulated through various molecular mechanisms. In fact, flavonoids are effective both in directly damaging the envelope of Gram-negative and Gram-positive bacteria but also by acting toward specific molecular targets essential for the survival of these microorganisms. The purpose of this paper is to present an overview of the most interesting results obtained in the research focused on the study of the interactions between flavonoids and bacterial proteins. Despite the great structural heterogeneity of these plant metabolites, it is interesting to observe that many flavonoids affect the same cellular pathways. Furthermore, it is evident that some of these compounds interact with more than one target, producing multiple effects. Taken together, the reported data demonstrate the great potential of flavonoids in developing innovative systems, which can help address the increasingly serious problem of antibiotic resistance. MDPI 2021-05-05 /pmc/articles/PMC8147964/ /pubmed/34062983 http://dx.doi.org/10.3390/pharmaceutics13050660 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Donadio, Giuliana Mensitieri, Francesca Santoro, Valentina Parisi, Valentina Bellone, Maria Laura De Tommasi, Nunziatina Izzo, Viviana Dal Piaz, Fabrizio Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids |
title | Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids |
title_full | Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids |
title_fullStr | Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids |
title_full_unstemmed | Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids |
title_short | Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids |
title_sort | interactions with microbial proteins driving the antibacterial activity of flavonoids |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147964/ https://www.ncbi.nlm.nih.gov/pubmed/34062983 http://dx.doi.org/10.3390/pharmaceutics13050660 |
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