Cargando…

Association of Calcitriol Supplementation with Reduced COVID-19 Mortality in Patients with Chronic Kidney Disease: A Population-Based Study

Treatment with calcitriol, the hormonal form of vitamin D, has shown beneficial effects in experimental models of acute lung injury. In this study, we aimed to analyze the associations between calcitriol supplementation and the risk of SARS-CoV2 infection or COVID-19 mortality. Individuals ≥18 years...

Descripción completa

Detalles Bibliográficos
Autores principales: Oristrell, Joaquim, Oliva, Joan Carles, Subirana, Isaac, Casado, Enrique, Domínguez, Didier, Toloba, Andrea, Aguilera, Patricia, Esplugues, Joan, Fafián, Pilar, Grau, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147982/
https://www.ncbi.nlm.nih.gov/pubmed/34063015
http://dx.doi.org/10.3390/biomedicines9050509
_version_ 1783697750850797568
author Oristrell, Joaquim
Oliva, Joan Carles
Subirana, Isaac
Casado, Enrique
Domínguez, Didier
Toloba, Andrea
Aguilera, Patricia
Esplugues, Joan
Fafián, Pilar
Grau, Maria
author_facet Oristrell, Joaquim
Oliva, Joan Carles
Subirana, Isaac
Casado, Enrique
Domínguez, Didier
Toloba, Andrea
Aguilera, Patricia
Esplugues, Joan
Fafián, Pilar
Grau, Maria
author_sort Oristrell, Joaquim
collection PubMed
description Treatment with calcitriol, the hormonal form of vitamin D, has shown beneficial effects in experimental models of acute lung injury. In this study, we aimed to analyze the associations between calcitriol supplementation and the risk of SARS-CoV2 infection or COVID-19 mortality. Individuals ≥18 years old living in Catalonia and supplemented with calcitriol from April 2019 to February 2020 were compared with propensity score matched controls. Outcome variables were SARS-CoV2 infection, severe COVID-19 and COVID-19 mortality. Associations between calcitriol supplementation and outcome variables were analyzed using multivariable Cox proportional regression. A total of 8076 patients were identified as being on calcitriol treatment. Advanced chronic kidney disease and hypoparathyroidism were the most frequent reasons for calcitriol supplementation in our population. Calcitriol use was associated with reduced risk of SARS-CoV2 infection (HR 0.78 [CI 95% 0.64–0.94], p = 0.010), reduced risk of severe COVID-19 and reduced COVID-19 mortality (HR 0.57 (CI 95% 0.41–0.80), p = 0.001) in patients with advanced chronic kidney disease. In addition, an inverse association between mean daily calcitriol dose and COVID-19 severity or mortality was observed in treated patients, independently of renal function. Our findings point out that patients with advanced chronic kidney disease could benefit from calcitriol supplementation during the COVID-19 pandemic.
format Online
Article
Text
id pubmed-8147982
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-81479822021-05-26 Association of Calcitriol Supplementation with Reduced COVID-19 Mortality in Patients with Chronic Kidney Disease: A Population-Based Study Oristrell, Joaquim Oliva, Joan Carles Subirana, Isaac Casado, Enrique Domínguez, Didier Toloba, Andrea Aguilera, Patricia Esplugues, Joan Fafián, Pilar Grau, Maria Biomedicines Article Treatment with calcitriol, the hormonal form of vitamin D, has shown beneficial effects in experimental models of acute lung injury. In this study, we aimed to analyze the associations between calcitriol supplementation and the risk of SARS-CoV2 infection or COVID-19 mortality. Individuals ≥18 years old living in Catalonia and supplemented with calcitriol from April 2019 to February 2020 were compared with propensity score matched controls. Outcome variables were SARS-CoV2 infection, severe COVID-19 and COVID-19 mortality. Associations between calcitriol supplementation and outcome variables were analyzed using multivariable Cox proportional regression. A total of 8076 patients were identified as being on calcitriol treatment. Advanced chronic kidney disease and hypoparathyroidism were the most frequent reasons for calcitriol supplementation in our population. Calcitriol use was associated with reduced risk of SARS-CoV2 infection (HR 0.78 [CI 95% 0.64–0.94], p = 0.010), reduced risk of severe COVID-19 and reduced COVID-19 mortality (HR 0.57 (CI 95% 0.41–0.80), p = 0.001) in patients with advanced chronic kidney disease. In addition, an inverse association between mean daily calcitriol dose and COVID-19 severity or mortality was observed in treated patients, independently of renal function. Our findings point out that patients with advanced chronic kidney disease could benefit from calcitriol supplementation during the COVID-19 pandemic. MDPI 2021-05-05 /pmc/articles/PMC8147982/ /pubmed/34063015 http://dx.doi.org/10.3390/biomedicines9050509 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Oristrell, Joaquim
Oliva, Joan Carles
Subirana, Isaac
Casado, Enrique
Domínguez, Didier
Toloba, Andrea
Aguilera, Patricia
Esplugues, Joan
Fafián, Pilar
Grau, Maria
Association of Calcitriol Supplementation with Reduced COVID-19 Mortality in Patients with Chronic Kidney Disease: A Population-Based Study
title Association of Calcitriol Supplementation with Reduced COVID-19 Mortality in Patients with Chronic Kidney Disease: A Population-Based Study
title_full Association of Calcitriol Supplementation with Reduced COVID-19 Mortality in Patients with Chronic Kidney Disease: A Population-Based Study
title_fullStr Association of Calcitriol Supplementation with Reduced COVID-19 Mortality in Patients with Chronic Kidney Disease: A Population-Based Study
title_full_unstemmed Association of Calcitriol Supplementation with Reduced COVID-19 Mortality in Patients with Chronic Kidney Disease: A Population-Based Study
title_short Association of Calcitriol Supplementation with Reduced COVID-19 Mortality in Patients with Chronic Kidney Disease: A Population-Based Study
title_sort association of calcitriol supplementation with reduced covid-19 mortality in patients with chronic kidney disease: a population-based study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147982/
https://www.ncbi.nlm.nih.gov/pubmed/34063015
http://dx.doi.org/10.3390/biomedicines9050509
work_keys_str_mv AT oristrelljoaquim associationofcalcitriolsupplementationwithreducedcovid19mortalityinpatientswithchronickidneydiseaseapopulationbasedstudy
AT olivajoancarles associationofcalcitriolsupplementationwithreducedcovid19mortalityinpatientswithchronickidneydiseaseapopulationbasedstudy
AT subiranaisaac associationofcalcitriolsupplementationwithreducedcovid19mortalityinpatientswithchronickidneydiseaseapopulationbasedstudy
AT casadoenrique associationofcalcitriolsupplementationwithreducedcovid19mortalityinpatientswithchronickidneydiseaseapopulationbasedstudy
AT dominguezdidier associationofcalcitriolsupplementationwithreducedcovid19mortalityinpatientswithchronickidneydiseaseapopulationbasedstudy
AT tolobaandrea associationofcalcitriolsupplementationwithreducedcovid19mortalityinpatientswithchronickidneydiseaseapopulationbasedstudy
AT aguilerapatricia associationofcalcitriolsupplementationwithreducedcovid19mortalityinpatientswithchronickidneydiseaseapopulationbasedstudy
AT espluguesjoan associationofcalcitriolsupplementationwithreducedcovid19mortalityinpatientswithchronickidneydiseaseapopulationbasedstudy
AT fafianpilar associationofcalcitriolsupplementationwithreducedcovid19mortalityinpatientswithchronickidneydiseaseapopulationbasedstudy
AT graumaria associationofcalcitriolsupplementationwithreducedcovid19mortalityinpatientswithchronickidneydiseaseapopulationbasedstudy