Cargando…
Association of Calcitriol Supplementation with Reduced COVID-19 Mortality in Patients with Chronic Kidney Disease: A Population-Based Study
Treatment with calcitriol, the hormonal form of vitamin D, has shown beneficial effects in experimental models of acute lung injury. In this study, we aimed to analyze the associations between calcitriol supplementation and the risk of SARS-CoV2 infection or COVID-19 mortality. Individuals ≥18 years...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147982/ https://www.ncbi.nlm.nih.gov/pubmed/34063015 http://dx.doi.org/10.3390/biomedicines9050509 |
_version_ | 1783697750850797568 |
---|---|
author | Oristrell, Joaquim Oliva, Joan Carles Subirana, Isaac Casado, Enrique Domínguez, Didier Toloba, Andrea Aguilera, Patricia Esplugues, Joan Fafián, Pilar Grau, Maria |
author_facet | Oristrell, Joaquim Oliva, Joan Carles Subirana, Isaac Casado, Enrique Domínguez, Didier Toloba, Andrea Aguilera, Patricia Esplugues, Joan Fafián, Pilar Grau, Maria |
author_sort | Oristrell, Joaquim |
collection | PubMed |
description | Treatment with calcitriol, the hormonal form of vitamin D, has shown beneficial effects in experimental models of acute lung injury. In this study, we aimed to analyze the associations between calcitriol supplementation and the risk of SARS-CoV2 infection or COVID-19 mortality. Individuals ≥18 years old living in Catalonia and supplemented with calcitriol from April 2019 to February 2020 were compared with propensity score matched controls. Outcome variables were SARS-CoV2 infection, severe COVID-19 and COVID-19 mortality. Associations between calcitriol supplementation and outcome variables were analyzed using multivariable Cox proportional regression. A total of 8076 patients were identified as being on calcitriol treatment. Advanced chronic kidney disease and hypoparathyroidism were the most frequent reasons for calcitriol supplementation in our population. Calcitriol use was associated with reduced risk of SARS-CoV2 infection (HR 0.78 [CI 95% 0.64–0.94], p = 0.010), reduced risk of severe COVID-19 and reduced COVID-19 mortality (HR 0.57 (CI 95% 0.41–0.80), p = 0.001) in patients with advanced chronic kidney disease. In addition, an inverse association between mean daily calcitriol dose and COVID-19 severity or mortality was observed in treated patients, independently of renal function. Our findings point out that patients with advanced chronic kidney disease could benefit from calcitriol supplementation during the COVID-19 pandemic. |
format | Online Article Text |
id | pubmed-8147982 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81479822021-05-26 Association of Calcitriol Supplementation with Reduced COVID-19 Mortality in Patients with Chronic Kidney Disease: A Population-Based Study Oristrell, Joaquim Oliva, Joan Carles Subirana, Isaac Casado, Enrique Domínguez, Didier Toloba, Andrea Aguilera, Patricia Esplugues, Joan Fafián, Pilar Grau, Maria Biomedicines Article Treatment with calcitriol, the hormonal form of vitamin D, has shown beneficial effects in experimental models of acute lung injury. In this study, we aimed to analyze the associations between calcitriol supplementation and the risk of SARS-CoV2 infection or COVID-19 mortality. Individuals ≥18 years old living in Catalonia and supplemented with calcitriol from April 2019 to February 2020 were compared with propensity score matched controls. Outcome variables were SARS-CoV2 infection, severe COVID-19 and COVID-19 mortality. Associations between calcitriol supplementation and outcome variables were analyzed using multivariable Cox proportional regression. A total of 8076 patients were identified as being on calcitriol treatment. Advanced chronic kidney disease and hypoparathyroidism were the most frequent reasons for calcitriol supplementation in our population. Calcitriol use was associated with reduced risk of SARS-CoV2 infection (HR 0.78 [CI 95% 0.64–0.94], p = 0.010), reduced risk of severe COVID-19 and reduced COVID-19 mortality (HR 0.57 (CI 95% 0.41–0.80), p = 0.001) in patients with advanced chronic kidney disease. In addition, an inverse association between mean daily calcitriol dose and COVID-19 severity or mortality was observed in treated patients, independently of renal function. Our findings point out that patients with advanced chronic kidney disease could benefit from calcitriol supplementation during the COVID-19 pandemic. MDPI 2021-05-05 /pmc/articles/PMC8147982/ /pubmed/34063015 http://dx.doi.org/10.3390/biomedicines9050509 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Oristrell, Joaquim Oliva, Joan Carles Subirana, Isaac Casado, Enrique Domínguez, Didier Toloba, Andrea Aguilera, Patricia Esplugues, Joan Fafián, Pilar Grau, Maria Association of Calcitriol Supplementation with Reduced COVID-19 Mortality in Patients with Chronic Kidney Disease: A Population-Based Study |
title | Association of Calcitriol Supplementation with Reduced COVID-19 Mortality in Patients with Chronic Kidney Disease: A Population-Based Study |
title_full | Association of Calcitriol Supplementation with Reduced COVID-19 Mortality in Patients with Chronic Kidney Disease: A Population-Based Study |
title_fullStr | Association of Calcitriol Supplementation with Reduced COVID-19 Mortality in Patients with Chronic Kidney Disease: A Population-Based Study |
title_full_unstemmed | Association of Calcitriol Supplementation with Reduced COVID-19 Mortality in Patients with Chronic Kidney Disease: A Population-Based Study |
title_short | Association of Calcitriol Supplementation with Reduced COVID-19 Mortality in Patients with Chronic Kidney Disease: A Population-Based Study |
title_sort | association of calcitriol supplementation with reduced covid-19 mortality in patients with chronic kidney disease: a population-based study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147982/ https://www.ncbi.nlm.nih.gov/pubmed/34063015 http://dx.doi.org/10.3390/biomedicines9050509 |
work_keys_str_mv | AT oristrelljoaquim associationofcalcitriolsupplementationwithreducedcovid19mortalityinpatientswithchronickidneydiseaseapopulationbasedstudy AT olivajoancarles associationofcalcitriolsupplementationwithreducedcovid19mortalityinpatientswithchronickidneydiseaseapopulationbasedstudy AT subiranaisaac associationofcalcitriolsupplementationwithreducedcovid19mortalityinpatientswithchronickidneydiseaseapopulationbasedstudy AT casadoenrique associationofcalcitriolsupplementationwithreducedcovid19mortalityinpatientswithchronickidneydiseaseapopulationbasedstudy AT dominguezdidier associationofcalcitriolsupplementationwithreducedcovid19mortalityinpatientswithchronickidneydiseaseapopulationbasedstudy AT tolobaandrea associationofcalcitriolsupplementationwithreducedcovid19mortalityinpatientswithchronickidneydiseaseapopulationbasedstudy AT aguilerapatricia associationofcalcitriolsupplementationwithreducedcovid19mortalityinpatientswithchronickidneydiseaseapopulationbasedstudy AT espluguesjoan associationofcalcitriolsupplementationwithreducedcovid19mortalityinpatientswithchronickidneydiseaseapopulationbasedstudy AT fafianpilar associationofcalcitriolsupplementationwithreducedcovid19mortalityinpatientswithchronickidneydiseaseapopulationbasedstudy AT graumaria associationofcalcitriolsupplementationwithreducedcovid19mortalityinpatientswithchronickidneydiseaseapopulationbasedstudy |