Shaker-IR K(+) channel gating in heavy water: Role of structural water molecules in inactivation

It has been reported earlier that the slow (C-type) inactivated conformation in K(v) channels is stabilized by a multipoint hydrogen-bond network behind the selectivity filter. Furthermore, MD simulations revealed that structural water molecules are also involved in the formation of this network loc...

Descripción completa

Detalles Bibliográficos
Autores principales: Szanto, Tibor G., Gaal, Szabolcs, Karbat, Izhar, Varga, Zoltan, Reuveny, Eitan, Panyi, Gyorgy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148028/
https://www.ncbi.nlm.nih.gov/pubmed/34014250
http://dx.doi.org/10.1085/jgp.202012742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148028/
https://www.ncbi.nlm.nih.gov/pubmed/34014250
http://dx.doi.org/10.1085/jgp.202012742

Ejemplares similares