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Shaker-IR K(+) channel gating in heavy water: Role of structural water molecules in inactivation
It has been reported earlier that the slow (C-type) inactivated conformation in K(v) channels is stabilized by a multipoint hydrogen-bond network behind the selectivity filter. Furthermore, MD simulations revealed that structural water molecules are also involved in the formation of this network loc...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148028/ https://www.ncbi.nlm.nih.gov/pubmed/34014250 http://dx.doi.org/10.1085/jgp.202012742 |