Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas

Keratin 1 (KRT1) is overexpressed in squamous carcinomas and associated with aggressive pathologies in breast cancer. Herein we report the design and preparation of the first Trp-based red fluorogenic amino acid, which is synthetically accessible in a few steps and displays excellent photophysical p...

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Autores principales: Subiros-Funosas, Ramon, Ho, Vivian Cheuk Lam, Barth, Nicole D., Mendive-Tapia, Lorena, Pappalardo, Morena, Barril, Xavier, Ma, Ruoyu, Zhang, Cheng-Bin, Qian, Bin-Zhi, Sintes, Miquel, Ghashghaei, Ouldouz, Lavilla, Rodolfo, Vendrell, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148049/
https://www.ncbi.nlm.nih.gov/pubmed/34123261
http://dx.doi.org/10.1039/c9sc05558d
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author Subiros-Funosas, Ramon
Ho, Vivian Cheuk Lam
Barth, Nicole D.
Mendive-Tapia, Lorena
Pappalardo, Morena
Barril, Xavier
Ma, Ruoyu
Zhang, Cheng-Bin
Qian, Bin-Zhi
Sintes, Miquel
Ghashghaei, Ouldouz
Lavilla, Rodolfo
Vendrell, Marc
author_facet Subiros-Funosas, Ramon
Ho, Vivian Cheuk Lam
Barth, Nicole D.
Mendive-Tapia, Lorena
Pappalardo, Morena
Barril, Xavier
Ma, Ruoyu
Zhang, Cheng-Bin
Qian, Bin-Zhi
Sintes, Miquel
Ghashghaei, Ouldouz
Lavilla, Rodolfo
Vendrell, Marc
author_sort Subiros-Funosas, Ramon
collection PubMed
description Keratin 1 (KRT1) is overexpressed in squamous carcinomas and associated with aggressive pathologies in breast cancer. Herein we report the design and preparation of the first Trp-based red fluorogenic amino acid, which is synthetically accessible in a few steps and displays excellent photophysical properties, and its application in a minimally-disruptive labelling strategy to prepare a new fluorogenic cyclopeptide for imaging of KRT1+ cells in whole intact tumour tissues.
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spelling pubmed-81480492021-06-11 Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas Subiros-Funosas, Ramon Ho, Vivian Cheuk Lam Barth, Nicole D. Mendive-Tapia, Lorena Pappalardo, Morena Barril, Xavier Ma, Ruoyu Zhang, Cheng-Bin Qian, Bin-Zhi Sintes, Miquel Ghashghaei, Ouldouz Lavilla, Rodolfo Vendrell, Marc Chem Sci Chemistry Keratin 1 (KRT1) is overexpressed in squamous carcinomas and associated with aggressive pathologies in breast cancer. Herein we report the design and preparation of the first Trp-based red fluorogenic amino acid, which is synthetically accessible in a few steps and displays excellent photophysical properties, and its application in a minimally-disruptive labelling strategy to prepare a new fluorogenic cyclopeptide for imaging of KRT1+ cells in whole intact tumour tissues. The Royal Society of Chemistry 2019-12-18 /pmc/articles/PMC8148049/ /pubmed/34123261 http://dx.doi.org/10.1039/c9sc05558d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Subiros-Funosas, Ramon
Ho, Vivian Cheuk Lam
Barth, Nicole D.
Mendive-Tapia, Lorena
Pappalardo, Morena
Barril, Xavier
Ma, Ruoyu
Zhang, Cheng-Bin
Qian, Bin-Zhi
Sintes, Miquel
Ghashghaei, Ouldouz
Lavilla, Rodolfo
Vendrell, Marc
Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas
title Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas
title_full Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas
title_fullStr Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas
title_full_unstemmed Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas
title_short Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas
title_sort fluorogenic trp(redbodipy) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148049/
https://www.ncbi.nlm.nih.gov/pubmed/34123261
http://dx.doi.org/10.1039/c9sc05558d
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