Mechanism of allosteric activation of SIRT6 revealed by the action of rationally designed activators

The recent discovery of activator compounds binding to an allosteric site on the NAD(+)-dependent protein lysine deacetylase, sirtuin 6 (SIRT6) has attracted interest and presents a pharmaceutical target for aging-related and cancer diseases. However, the mechanism underlying allosteric activation o...

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Detalles Bibliográficos
Autores principales: Lu, Shaoyong, Chen, Yingyi, Wei, Jiacheng, Zhao, Mingzhu, Ni, Duan, He, Xinheng, Zhang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148055/
https://www.ncbi.nlm.nih.gov/pubmed/34094839
http://dx.doi.org/10.1016/j.apsb.2020.09.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148055/
https://www.ncbi.nlm.nih.gov/pubmed/34094839
http://dx.doi.org/10.1016/j.apsb.2020.09.010

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