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Mechanism of allosteric activation of SIRT6 revealed by the action of rationally designed activators
The recent discovery of activator compounds binding to an allosteric site on the NAD(+)-dependent protein lysine deacetylase, sirtuin 6 (SIRT6) has attracted interest and presents a pharmaceutical target for aging-related and cancer diseases. However, the mechanism underlying allosteric activation o...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148055/ https://www.ncbi.nlm.nih.gov/pubmed/34094839 http://dx.doi.org/10.1016/j.apsb.2020.09.010 |