Expanding medicinal chemistry into 3D space: metallofragments as 3D scaffolds for fragment-based drug discovery

Fragment-based drug discovery (FBDD) is a powerful strategy for the identification of new bioactive molecules. FBDD relies on fragment libraries, generally of modest size, but of high chemical diversity. Although good chemical diversity in FBDD libraries has been achieved in many respects, achieving...

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Detalles Bibliográficos
Autores principales: Morrison, Christine N., Prosser, Kathleen E., Stokes, Ryjul W., Cordes, Anna, Metzler-Nolte, Nils, Cohen, Seth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148059/
https://www.ncbi.nlm.nih.gov/pubmed/34123246
http://dx.doi.org/10.1039/c9sc05586j

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