The poly(ADP-ribosyl)ation of BRD4 mediated by PARP1 promoted pathological cardiac hypertrophy

The bromodomain and extraterminal (BET) family member BRD4 is pivotal in the pathogenesis of cardiac hypertrophy. BRD4 induces hypertrophic gene expression by binding to the acetylated chromatin, facilitating the phosphorylation of RNA polymerases II (Pol II) and leading to transcription elongation....

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Detalles Bibliográficos
Autores principales: Li, Zhenzhen, Guo, Zhen, Lan, Rui, Cai, Sidong, Lin, Zhirong, Li, Jingyan, Wang, Junjian, Li, Zhuoming, Liu, Peiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148063/
https://www.ncbi.nlm.nih.gov/pubmed/34094834
http://dx.doi.org/10.1016/j.apsb.2020.12.012

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