Roles of long non-coding RNA in osteoarthritis (Review)

Osteoarthritis (OA) is a chronic bone and joint disease characterized by articular cartilage degeneration and joint inflammation and is the most common form of arthritis. The clinical manifestations of OA are chronic pain and joint activity disorder, which severely affect the patient quality of life...

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Autores principales: Wang, Jicheng, Sun, Yanshan, Liu, Jianyong, Yang, Bo, Wang, Tengyun, Zhang, Zhen, Jiang, Xin, Guo, Yongzhi, Zhang, Yangyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148092/
https://www.ncbi.nlm.nih.gov/pubmed/34013375
http://dx.doi.org/10.3892/ijmm.2021.4966
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author Wang, Jicheng
Sun, Yanshan
Liu, Jianyong
Yang, Bo
Wang, Tengyun
Zhang, Zhen
Jiang, Xin
Guo, Yongzhi
Zhang, Yangyang
author_facet Wang, Jicheng
Sun, Yanshan
Liu, Jianyong
Yang, Bo
Wang, Tengyun
Zhang, Zhen
Jiang, Xin
Guo, Yongzhi
Zhang, Yangyang
author_sort Wang, Jicheng
collection PubMed
description Osteoarthritis (OA) is a chronic bone and joint disease characterized by articular cartilage degeneration and joint inflammation and is the most common form of arthritis. The clinical manifestations of OA are chronic pain and joint activity disorder, which severely affect the patient quality of life. Long non-coding RNA (lncRNA) is a class of RNA molecules >200 nucleotides long that are expressed in animals, plants, yeast, prokaryotes and viruses. lncRNA molecules lack an open reading frame and are not translated into protein. The present review collated the results of recent studies on the role of lncRNA in the pathogenesis of OA to provide information for the prevention, diagnosis and treatment of OA.
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spelling pubmed-81480922021-05-28 Roles of long non-coding RNA in osteoarthritis (Review) Wang, Jicheng Sun, Yanshan Liu, Jianyong Yang, Bo Wang, Tengyun Zhang, Zhen Jiang, Xin Guo, Yongzhi Zhang, Yangyang Int J Mol Med Articles Osteoarthritis (OA) is a chronic bone and joint disease characterized by articular cartilage degeneration and joint inflammation and is the most common form of arthritis. The clinical manifestations of OA are chronic pain and joint activity disorder, which severely affect the patient quality of life. Long non-coding RNA (lncRNA) is a class of RNA molecules >200 nucleotides long that are expressed in animals, plants, yeast, prokaryotes and viruses. lncRNA molecules lack an open reading frame and are not translated into protein. The present review collated the results of recent studies on the role of lncRNA in the pathogenesis of OA to provide information for the prevention, diagnosis and treatment of OA. D.A. Spandidos 2021-07 2021-05-19 /pmc/articles/PMC8148092/ /pubmed/34013375 http://dx.doi.org/10.3892/ijmm.2021.4966 Text en Copyright: © Wang et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Wang, Jicheng
Sun, Yanshan
Liu, Jianyong
Yang, Bo
Wang, Tengyun
Zhang, Zhen
Jiang, Xin
Guo, Yongzhi
Zhang, Yangyang
Roles of long non-coding RNA in osteoarthritis (Review)
title Roles of long non-coding RNA in osteoarthritis (Review)
title_full Roles of long non-coding RNA in osteoarthritis (Review)
title_fullStr Roles of long non-coding RNA in osteoarthritis (Review)
title_full_unstemmed Roles of long non-coding RNA in osteoarthritis (Review)
title_short Roles of long non-coding RNA in osteoarthritis (Review)
title_sort roles of long non-coding rna in osteoarthritis (review)
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148092/
https://www.ncbi.nlm.nih.gov/pubmed/34013375
http://dx.doi.org/10.3892/ijmm.2021.4966
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