Cargando…

Oral Supplementation of an Alkylglycerol Mix Comprising Different Alkyl Chains Effectively Modulates Multiple Endogenous Plasmalogen Species in Mice

Plasmalogens or alkenylphospholipids are a sub-class of glycerophospholipids with numerous biological functions and are thought to have protective effects against metabolic disease. Dietary supplementation with alkylglycerols (AKGs) has been shown to increase endogenous plasmalogen levels, however e...

Descripción completa

Detalles Bibliográficos
Autores principales: Paul, Sudip, Rasmiena, Aliki A., Huynh, Kevin, Smith, Adam Alexander T., Mellett, Natalie A., Jandeleit-Dahm, Karin, Lancaster, Graeme I., Meikle, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148155/
https://www.ncbi.nlm.nih.gov/pubmed/34066368
http://dx.doi.org/10.3390/metabo11050299
_version_ 1783697790486970368
author Paul, Sudip
Rasmiena, Aliki A.
Huynh, Kevin
Smith, Adam Alexander T.
Mellett, Natalie A.
Jandeleit-Dahm, Karin
Lancaster, Graeme I.
Meikle, Peter J.
author_facet Paul, Sudip
Rasmiena, Aliki A.
Huynh, Kevin
Smith, Adam Alexander T.
Mellett, Natalie A.
Jandeleit-Dahm, Karin
Lancaster, Graeme I.
Meikle, Peter J.
author_sort Paul, Sudip
collection PubMed
description Plasmalogens or alkenylphospholipids are a sub-class of glycerophospholipids with numerous biological functions and are thought to have protective effects against metabolic disease. Dietary supplementation with alkylglycerols (AKGs) has been shown to increase endogenous plasmalogen levels, however effective modulation of different molecular plasmalogen species has not yet been demonstrated. In this study, the effects of an orally-administered AKG mix (a mixture of chimyl, batyl and selachyl alcohol at a 1:1:1 ratio) on plasma and tissue lipids, including plasmalogens, was evaluated. Mice on a Western-type diet were treated with either an AKG mix or vehicle (lecithin) for 1, 2, 4, 8 and 12 weeks. Treatment with the AKG mix significantly increased the total plasmalogen content of plasma, liver and adipose tissue as a result of elevations in multiple plasmalogen species with different alkenyl chains. Alkylphospholipids, the endogenous precursors of plasmalogens, showed a rapid and significant increase in plasma, adipose tissue, liver and skeletal muscle. A significant accumulation of alkyl-diacylglycerol and lyso-ether phospholipids was also observed in plasma and tissues. Additionally, the dynamics of plasmalogen-level changes following AKG mix supplementation differed between tissues. These findings indicate that oral supplementation with an AKG mix is capable of upregulating and maintaining stable expression of multiple molecular plasmalogen species in circulation and tissues.
format Online
Article
Text
id pubmed-8148155
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-81481552021-05-26 Oral Supplementation of an Alkylglycerol Mix Comprising Different Alkyl Chains Effectively Modulates Multiple Endogenous Plasmalogen Species in Mice Paul, Sudip Rasmiena, Aliki A. Huynh, Kevin Smith, Adam Alexander T. Mellett, Natalie A. Jandeleit-Dahm, Karin Lancaster, Graeme I. Meikle, Peter J. Metabolites Article Plasmalogens or alkenylphospholipids are a sub-class of glycerophospholipids with numerous biological functions and are thought to have protective effects against metabolic disease. Dietary supplementation with alkylglycerols (AKGs) has been shown to increase endogenous plasmalogen levels, however effective modulation of different molecular plasmalogen species has not yet been demonstrated. In this study, the effects of an orally-administered AKG mix (a mixture of chimyl, batyl and selachyl alcohol at a 1:1:1 ratio) on plasma and tissue lipids, including plasmalogens, was evaluated. Mice on a Western-type diet were treated with either an AKG mix or vehicle (lecithin) for 1, 2, 4, 8 and 12 weeks. Treatment with the AKG mix significantly increased the total plasmalogen content of plasma, liver and adipose tissue as a result of elevations in multiple plasmalogen species with different alkenyl chains. Alkylphospholipids, the endogenous precursors of plasmalogens, showed a rapid and significant increase in plasma, adipose tissue, liver and skeletal muscle. A significant accumulation of alkyl-diacylglycerol and lyso-ether phospholipids was also observed in plasma and tissues. Additionally, the dynamics of plasmalogen-level changes following AKG mix supplementation differed between tissues. These findings indicate that oral supplementation with an AKG mix is capable of upregulating and maintaining stable expression of multiple molecular plasmalogen species in circulation and tissues. MDPI 2021-05-06 /pmc/articles/PMC8148155/ /pubmed/34066368 http://dx.doi.org/10.3390/metabo11050299 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Paul, Sudip
Rasmiena, Aliki A.
Huynh, Kevin
Smith, Adam Alexander T.
Mellett, Natalie A.
Jandeleit-Dahm, Karin
Lancaster, Graeme I.
Meikle, Peter J.
Oral Supplementation of an Alkylglycerol Mix Comprising Different Alkyl Chains Effectively Modulates Multiple Endogenous Plasmalogen Species in Mice
title Oral Supplementation of an Alkylglycerol Mix Comprising Different Alkyl Chains Effectively Modulates Multiple Endogenous Plasmalogen Species in Mice
title_full Oral Supplementation of an Alkylglycerol Mix Comprising Different Alkyl Chains Effectively Modulates Multiple Endogenous Plasmalogen Species in Mice
title_fullStr Oral Supplementation of an Alkylglycerol Mix Comprising Different Alkyl Chains Effectively Modulates Multiple Endogenous Plasmalogen Species in Mice
title_full_unstemmed Oral Supplementation of an Alkylglycerol Mix Comprising Different Alkyl Chains Effectively Modulates Multiple Endogenous Plasmalogen Species in Mice
title_short Oral Supplementation of an Alkylglycerol Mix Comprising Different Alkyl Chains Effectively Modulates Multiple Endogenous Plasmalogen Species in Mice
title_sort oral supplementation of an alkylglycerol mix comprising different alkyl chains effectively modulates multiple endogenous plasmalogen species in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148155/
https://www.ncbi.nlm.nih.gov/pubmed/34066368
http://dx.doi.org/10.3390/metabo11050299
work_keys_str_mv AT paulsudip oralsupplementationofanalkylglycerolmixcomprisingdifferentalkylchainseffectivelymodulatesmultipleendogenousplasmalogenspeciesinmice
AT rasmienaalikia oralsupplementationofanalkylglycerolmixcomprisingdifferentalkylchainseffectivelymodulatesmultipleendogenousplasmalogenspeciesinmice
AT huynhkevin oralsupplementationofanalkylglycerolmixcomprisingdifferentalkylchainseffectivelymodulatesmultipleendogenousplasmalogenspeciesinmice
AT smithadamalexandert oralsupplementationofanalkylglycerolmixcomprisingdifferentalkylchainseffectivelymodulatesmultipleendogenousplasmalogenspeciesinmice
AT mellettnataliea oralsupplementationofanalkylglycerolmixcomprisingdifferentalkylchainseffectivelymodulatesmultipleendogenousplasmalogenspeciesinmice
AT jandeleitdahmkarin oralsupplementationofanalkylglycerolmixcomprisingdifferentalkylchainseffectivelymodulatesmultipleendogenousplasmalogenspeciesinmice
AT lancastergraemei oralsupplementationofanalkylglycerolmixcomprisingdifferentalkylchainseffectivelymodulatesmultipleendogenousplasmalogenspeciesinmice
AT meiklepeterj oralsupplementationofanalkylglycerolmixcomprisingdifferentalkylchainseffectivelymodulatesmultipleendogenousplasmalogenspeciesinmice